Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

How left/right functional asymmetry is layered on top of an anatomically symmetrical nervous system is poorly understood. In the nematode Caenorhabditis elegans, two morphologically bilateral taste receptor neurons, ASE left (ASEL) and ASE right (ASER), display a left/right asymmetrical expression pattern of putative chemoreceptor genes that correlates with a diversification of chemosensory specificities. Here we show that a previously undefined microRNA termed lsy-6 controls this neuronal left/right asymmetry of chemosensory receptor expression. lsy-6 mutants that we retrieved from a genetic screen for defects in neuronal left/right asymmetry display a loss of the ASEL-specific chemoreceptor expression profile with a concomitant gain of the ASER-specific profile. A lsy-6 reporter gene construct is expressed in less than ten neurons including ASEL, but not ASER. lsy-6 exerts its effects on ASEL through repression of cog-1, an Nkx-type homeobox gene, which contains a lsy-6 complementary site in its 3' untranslated region and that has been shown to control ASE-specific chemoreceptor expression profiles. lsy-6 is the first microRNA to our knowledge with a role in neuronal patterning, providing new insights into left/right axis formation.
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PMID:A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. 1468 40

We report on high-resolution X-ray diffraction and time-resolved photoluminescence (TR-PL) studies of antimonide-based midinfrared (MIR) type-II laser samples. A structural characterization taking into account asymmetrical strain, layer tilting, and relaxation enables an accurate determination of the average lattice constant of the active region and the composition of the cladding layers. By designing the antimonide-to-arsenide interfaces, we achieve exact lattice matching of the active region to the substrate. Non-radiative recombination processes are investigated with time-resolved photoluminescence. The samples are also characterized under optically pumped laser operation. By an examination of the time-integrated and time-resolved amplified spontaneous emission (TR-ASE), we investigate the modal gain and gain dynamics. The variable stripe length method is combined with the TR-PL approach. Compared to the time-integrated gain spectra the spectral dependence of the maximum and minimum time-resolved gain shows a broad plateau. The full width half maximum (FWHM) of the TR-ASE pulse is 5.5 +/- 0.5 ps. Thus, short pulses in this range should be achievable upon laser operation. The active regions of the laser structures investigated here are promising subunits of type-II quantum cascade lasers.
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PMID:X-ray studies and time-resolved photoluminescence on optically pumped antimonide-based midinfrared type-II lasers. 1556 24