Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Asthmatic amyotrophy is becoming a well established clinical phenomenon. A polio-like syndrome, it is characterized by an asymmetrical lower motor neuron paralysis after an acute asthmatic episode. We are presenting three additional cases of this syndrome to add to the literature describing this phenomenon. Our cases are similar to the 18 previously reported cases showing an asymmetrical flaccid paralysis accompanied by normal sensation. The prognosis for full recovery of function is poor. Anterior horn cell damage is postulated because no sensory loss has been found in any patients.
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PMID:Asthmatic amyotrophy. Three cases. 174 5

The mode of right ventricular hypertrophy was assessed by two-dimensional echocardiography (2DE) for 24 patients with hypertrophic cardiomyopathy (HCM), and the results were compared with those of 51 patients with hypertension (HT). The patients with HT were categorized in four groups depending on the thickness of the interventricular septum (IVST) and left ventricular posterior wall (PWT): HT-ASH with both left ventricular hypertrophy (LVH) (IVST greater than or equal to 13 mm) and asymmetric septal hypertrophy (ASH) (IVST/PWT greater than or equal to 1.3), severe HT with LVH and without ASH, and mild HT without LVH and ASH. Anterior wall thickness (AWT), posterior wall thickness (PWT), and diaphragmatic wall thickness (DWT) of the right ventricle were obtained from 2DE in the parasternal long-axis view, the short-axis view and subxiphoid view, respectively. These were recorded on video tape, and the measurements were made on the stop frames. Right ventricular hypertrophy (RVH) was estimated by the maximal right ventricular wall thickness (max RVWT), and the ratio of the maximal and minimal thickness (max RVWT/min RVWT) was calculated to evaluate asymmetrical hypertrophy (AH) of the right ventricle (RV). The incidence of RVH (Max RVWT greater than or equal to 5 mm) and asymmetrical hypertrophy (AH) (max RVWT/min RVWT greater than or equal to 1.3) of the RV in HCM, HT-ASH and mild HT were 67% and 41%, 57% and 45%, and 15% and 11%, respectively. The incidence of RVH with AH was more frequent in patients with HCM as well as HT with ASH than in patients with HT without ASH.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Regional right ventricular hypertrophy in hypertrophic cardiomyopathy and hypertension]. 409 19

The temporomandibular joint (TMJ) and dental occlusion were investigated clinically and radiographically in 59 patients aged 23-83 (mean, 58) years with general joint disease. Forty-nine had rheumatoid arthritis (RA), mostly of long duration. The patients were divided into four groups by type of dentition. Radiographic TMJ abnormality was found in about 4 of 5 patients with RA, in both the dentate and the edentulous group. The abnormality was mainly destructive with productive signs, but in the edentulous group erosive and asymmetrical changes occurred more often. Almost complete restriction of the condylar translation and severely restricted mouth opening (less than or equal to 30 mm) rarely occurred, although the translatory motion was restricted in several patients. Many of these had a satisfactory mouth opening (greater than 40 mm). Occlusal changes-various degrees of anterior bite opening-were reported by about one fourth of both the dentate patients and the complete denture wearers. One patient had occlusal contact on the second molars only. Anterior bite opening occurred only in patients with radiographic TMJ abnormality, including 5 of the 6 patients with complete mandibular head destruction.
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PMID:Temporomandibular joint involvement and dental occlusion in a group of adults with rheumatoid arthritis. 658 69

The first cleavage of the Caenorhabditis elegans embryo is asymmetrical, producing daughters with different cell fates. During the first cell cycle, P granules, cytoplasmic components that are segregated to the germ-line, are localized to the posterior of the embryo. It has been hypothesized that the asymmetrical behavior of the daughters of the first division results from a similar localization of developmental determinants. A process called pseudocleavage also occurs during the first cell cycle: Anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. Coincident with pseudocleavage, there is an anteriorly directed flow of cortical cytoplasm and a posteriorly directed flow of internal cytoplasm. Foci of filamentous cortical actin become asymmetrically distributed into an anterior cap. Roles for these various first cell cycle events in cytoplasmic localization and development have been suggested but remain unclear. We have isolated a maternal effect mutation, nop-1(it142), which abolishes the anterior cortical contractions and the pseudocleavage furrow. In addition, cortical actin foci remain uniformly distributed in most embryos. Despite these defects, cytoplasmic and cortical streaming is present and P granules are localized to the posterior of early embryos. In most embryos from mutant mothers, development proceeds normally and the embryos hatch and grow into fertile adults. We conclude that the pseudocleavage contractions and furrow are dispensable for the development of C. elegans.
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PMID:Pseudocleavage is dispensable for polarity and development in C. elegans embryos. 772 83

Interhemispheric relay time (IHRT) was investigated using a 16-electrode montage in 10 normal subjects during a simple visual reaction time task (Poffenberger paradigm). The P1 latency was the dependent measure. Response-locked components were separated from the stimulus-locked components based on the reaction times using a Woldorff-like filter. The issues of theoretical interest were the following: (1) does the responding hand modulate IHRT estimates as a function of electrode site, or stimulated field?; (2) what are the respective advantages of various pairs of symmetrical across-midline electrode sites for tracking IHRT?; and (3) what are the respective advantages of symmetrical vs. asymmetrical across-midline electrode site-pair configurations for tracking IHRT? There were significant lags attributable to IHRT in both evoked potential P1 latencies and in reaction times--but these were uncorrelated. The responding hand was not found to significantly modulate IHRT estimates derived from the P1 peak latency of response-corrected ERPs. Anterior sites yielded more precocious components and briefer estimates of IHRT which were closer to those observed in reaction time estimates. However, posterior leads yielded more reliable estimates. Various analyses suggested that IHRT can be tracked, very vaguely, with asymmetric configurations as well as symmetric ones, each for different reasons.
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PMID:Topography of averaged electrical brain activity relating to interhemispheric dynamics in normal humans: where does the critical relay take place? 1019 4

Isolated paralysis of the marginal mandibular branch of the facial nerve results in an asymmetrical smile with elevation of the lower lip on the affected side. We discuss the surgical options for its correction and present a series of 26 patients who underwent either botulinum toxin injection, anterior belly of digastric transfer or free extensor digitorum brevis transfer as treatment. Botulinum toxin injection provided satisfactory results although these were temporary. Anterior belly of digastric transfer was the surgical procedure of choice. It yielded superior cosmetic results, less donor-site morbidity and required a shorter operating time. In more complex congenital facial hypoplastic syndromes, or following extensive surgery in the digastric triangle, the anterior belly of the digastric muscle may be absent or damaged. Extensor digitorum brevis transfer is the preferred option in these cases.
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PMID:Paralysis of the marginal mandibular branch of the facial nerve: treatment options. 1087 73

We describe the arrangement of white muscle fibers and tendinous myoseptal structures and the relation of these structures to each other in order to provide an anatomical framework for discussions and experimental research on fish swimming mechanics. For the three major craniate groups, the petromyzontids, myxinids and gnathostomes, we identify three conditions that differ remarkably. Myxinids are characterized by asymmetrical myosepta with long cones. Within a single myoseptum these are connected by collagenous fibers that are almost oriented longitudinally. Distinct tendons are absent in myxinid myosepta. Petromyzontid myosepta lack cones and distinct myoseptal tendons, whereas gnathostomes bear cones and distinct tendinous structures: the lateral band, epineural (epipleural) tendon and myhabdoid tendon. Myoseptal fibers of petromyzontids and myoseptal tendons of gnathostome myosepta are firmly anchored in the skin. Myxinids lack firm myoseptal-skin-connections. Their muscular arrangement is neither comparable to that of petromyzontids nor to that of gnathostomes. The latter two bear archlike arrangements of muscle fibers spanning several segments that are hypothesized to play a role during bending. In gnathostomes, archlike helical muscle fiber arrangements (HMFAs) are present that span the length of several body segments and are multiply intersected by myosepta. Hence, a series of tendinous lateral bands of myosepta is embedded in HMFAs. The posterodorsally oriented HMFAs are underlain by posteroventrally oriented crossing muscle fibers (CMFs). Bending may be generated by contraction of the muscle fibers belonging to an HMFA and the simultaneous counteraction of CMFs. Moving caudally, this anterior muscle fiber arrangement gradually changes, eventually becoming the posterior muscle fiber arrangement. This pattern suggests that the function of the myomeres will also change. Three additional putative roles of myoseptal tendons can be deduced from their relations to white muscle fibers in gnathostomes (and in part in petromyzontids): (1) Posterior transmission of anteriorly generated muscular forces via lateral bands and/or myorhabdoid tendons. These tendons are more robust posteriorly. Anterior and posterior cones appear to play an important role in force transmission. (2) Pulling on collagen fibers of the skin via lateral bands and myorhabdoid tendons, suggesting a transmission of muscular forces that puts the skin into tension. (3) Resisting radial expansion of contracting muscle fibers by epineural (epipleural) tendons. By the latter two mechanisms modulation of body stiffness is likely to be achieved.
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PMID:Spatial arrangement of white muscle fibers and myoseptal tendons in fishes. 1248 90

Extraocular muscle (EOM) paths during asymmetrical convergence were evaluated by tri-planar, contrast-enhanced magnetic resonance imaging of the orbits of eight young adults during binocular fixation of a target aligned to one eye at 800 and 15 cm distance. Cross sections and paths of EOMs were determined from area centroids. In convergence, the aligned eye rotated and translated negligibly, while its inferior oblique (IO) muscle exhibited significant contractile thickening. There were no significant contractile changes in the cross sections of aligned eye rectus or superior oblique (SO) muscles in convergence. The converging eye rotated nasally 22.4 degrees but translated negligibly. The converging eye medial (MR) and lateral rectus (LR) muscles exhibited large contractile cross-section changes, and the IO showed significant contractile thickening, while the vertical rectus muscles and the SO did not. Anterior paths of three aligned eye rectus EOMs could be determined in convergence and shifted consistent with a 1.9 degrees extorsion of the rectus pulley array. Such extorsional reconfiguration of the rectus pulleys would move the pulleys in coordination with globe extorsion and avoid imparting torsional action to these EOMs. Extorsional rectus pulley shift in convergence is inconsistent with the reconfiguration predicted to explain the temporal tilting of Listing's planes, instead suggesting that this temporal tilting is due to variations in oblique EOM innervation. Absence of globe translation in convergence argues against overall EOM co-contraction. The reconfiguration of EOM geometry in convergence has important implications for single-unit studies of neural control.
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PMID:Magnetic resonance imaging of human extraocular muscles in convergence. 1268 79

This study analyzed the occlusions of 489 children at the onset of the mixed dentition period (mean age 5.1 years, range 4.0-7.8 years). These children participate in an ongoing clinical trial that is investigating the effects of orthodontic intervention in the early mixed dentition. The aim was to report the occlusal findings at the baseline. The frequencies of mesial step, flush terminal plane, and distal step were 19.1%, 47.8%, and 33.1%, respectively. The canine relationship was Class I in 46.1%, Class II in 52.4%, and Class III in 1.5% of the sides examined. An asymmetrical canine relationship was found in 30.1% of the children, significantly more often on the right side than on the left (P <.001). Overjet ranged from -2 to +10 mm with a mean of 2.9 mm. Overbite ranged from -5 to +8 mm with a mean of 2.8 mm. Excessive (> or =4 mm) overjet was found in 26.7% and overbite in 33.8% of the children; in 15.5% of the children, both variables were 4 mm or more. Anterior crowding was detected in the maxillary arch in 11.6% and in the mandibular arch in 38.9% of the children. Girls showed mandibular crowding more often than boys (P <.01). A posterior crossbite was found in 7.5% of the children, unilaterally in 6.4% and bilaterally in 1.1%. Scissors-bite was detected in 1.1% and an anterior crossbite in 2.2% of the children. The mean maximal opening was 40.3 mm. Joint sounds were registered in 5.2% of the children. The prevalence of malocclusion was between 67.7% and 92.7%, depending on the values of unacceptable parameters used for each occlusal characteristic.
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PMID:Occurrence of malocclusion and need of orthodontic treatment in early mixed dentition. 1502 83

Previous studies in humans and animals which have shown that DC galvanic vestibular stimulation (GVS) induces horizontal and torsional eye movements have been interpreted as being due to a preferential activation of primary vestibular afferents innervating the horizontal semicircular canals and otoliths by GVS. The present study sought to determine in guinea pigs whether GVS does indeed selectively activate primary horizontal canal and otolith afferents. Constant-current GVS was passed between electrodes implanted in the tensor-tympani muscle of each middle ear or between electrodes on the skin over the mastoid. During this stimulation, responses from single primary vestibular neurons were recorded extracellularly by glass microelectrodes in Scarpa's ganglion. Afferents from all vestibular sensory regions were activated by both surface and tensor-tympani galvanic stimulation. Tensor tympani GVS was approximately 10 times more effective than surface GVS. At larger current intensities irregularly discharging afferents showed an asymmetrical response: cathodal stimulation resulted in a larger change in firing (increase) than anodal stimulation (decrease), whereas regularly discharging afferents responded symmetrically to the two polarities of GVS. Across all afferents tuned for different types of natural vestibular stimulation, neuronal sensitivity for GVS was found to increase with discharge variability (as indexed by CV*). Anterior canal afferents showed a slightly higher sensitivity than afferents from other vestibular sensory regions. Hence, the present study concluded that GVS activates primary vestibular afferents innervating all sensory regions in a uniform fashion. Therefore, the specific pattern of GVS-induced eye movements reported in previous studies are not due to differential sensitivity between different vestibular sensory regions, but are likely to reflect an involvement of central processing.
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PMID:Responses of primary vestibular neurons to galvanic vestibular stimulation (GVS) in the anaesthetised guinea pig. 1546 64


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