Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Microcrystalline arthropathies of the wrist include three main forms of microcrystalline pathology: gout, chondrocalcinosis and apatite calcifications. Gout of the wrist is now rare and may be missed, particularly in its chronic form, occasionally associated with tophi and large, often asymmetrical erosions on the X-rays. Chondrocalcinosis is frequent and easy to diagnose in the wrist and may be responsible for a very typical arthropathy predominantly involving the radiocarpal joint, while the frequency and specificity of scapho-trapezoid involvement are controversial. Apatite deposits in the wrist involve various tendons and ligaments, especially the tendon of flexor carpi ulnaris, but may also be responsible for intra-articular pathology.
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PMID:[Microcrystal deposit arthropathies of the wrist]. 133 92

The authors describe a systematic approach to plain-film diagnosis of joint disease. The major radiologic criteria--soft-tissue swelling, joint-space narrowing, bone erosion, bone sclerosis and osteophytosis, and chondrocalcinosis--are considered first. Assessing the involvement of the minor criteria of joint disease--soft-tissue atrophy or calcification, malalignment, osteoporosis, abnormal growth, intra-articular bony ankylosis, bone fragmentation, periostitis, subperiosteal resorption or acro-osteolysis--narrows the probabilities to the more likely diagnoses. Further analysis includes the distribution of joint injury, whether mono- or polyarticular, symmetrical or asymmetrical. Added to clinical information, this approach leads to a specific or refined differential diagnosis.
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PMID:Plain-film diagnosis of joint disease. 203 62

Radiological gout manifestations are detectable in the early stage, but also especially in the chronic stage of gout. Whereas in the early stage only soft tissue mutations (bursitis inflammation) and light calcium deposits are usually discernible, chronic gout leads to asymmetrical, diverse forms of osseous destruction, favouring smaller joints, but also affecting larger ones, which are caused by the intra-articular and extra-articular deposit of tophus material, corresponding to the progression and degree of severity of the illness. Radiologically-detectable changes in other organs, such as the kidneys, will be addressed. The high number of, and to some extent very characteristic, osseous mutations are compared with those mutations which are very similar to the diagnoses of other syndromes affecting the joints. Specifically, problems in differentiating diagnosis of rheumatoid arthritis, arthritis psoriatica, chondrocalcinosis, and other diseases of the joints will receive special mention. Reference is also made to the extreme diagnostic difficulties resulting from the rare but nevertheless conceivable influence of gout on the spine or sacroiliac joints. The method of magnetic resonance imaging for gout shows a characteristic signal behaviour of the tophus material. It has been determined that, through magnetic resonance tomography, interosseous tophi can be detected earlier and in a more widespread manner than with the aid of native X-ray images, such that an increase in the use of this method is to be expected.
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PMID:[Radiologic findings in gout]. 944 16