Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P50583 (
asymmetrical
)
12,197
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The North American
Multiple System Atrophy
Study Group involves investigators in 12 US medical centers funded by a grant from the National Institutes of Health. The objectives are to examine the environmental and genetic risk factors for MSA; elucidate pathogenic mechanisms underlying the disorder; and refine evaluations used for assessment. During its first year, the group enrolled 87 patients, implemented four cores, and initiated four scientific projects. Most patients among the 87 had parkinsonian features, which frequently began asymmetrically and remained
asymmetrical
; one-third responded to levodopa and many developed levodopa complications; almost two-thirds of the patients had cerebellar dysfunction, of these 90% had ataxia; urinary incontinence occurred commonly, and sleep disorders affected most. The investigators studied the effects of oxidative and nitrative stress upon the formation of alpha-synuclein inclusions; generated transgenic models of alpha-synuclein accumulation that recapitulate several behavioral and neuropathological features of MSA; and compared the severity of the autonomic features of MSA, Parkinson's disease and dementia with Lewy bodies.
...
PMID:The North American Multiple System Atrophy Study Group. 1628 10
Multiple system atrophy
(
MSA
), an atypical parkinsonism of alpha-synucleinopathies, has no specific biomarker of diagnosis. According to different combinations of symptoms,
MSA
can be classified as parkinsonism-type
MSA
(MSA-P) and cerebellar-type
MSA
(MSA-C; Watanabe et al., 2018). Amide proton transfer (APT) imaging is by far the most studied chemical exchange saturation transfer imaging for its sensitivity to mobile protons and peptides in tissues. We hypothesize that APT imaging may be a feasible biomarker of
MSA
-P. Twenty
MSA
-P patients and 20 age-matched normal controls were enrolled in this study and underwent MR exams on a 3.0-T MR scanner. Magnetization transfer spectra at 3.5 ppm were acquired at two transverse slices of the head, including the midbrain and the basal ganglia. Mann-Whitney
U
test was used to compare the
asymmetrical
magnetization transfer ratio (MTR
asym
) difference between
MSA
-P patients and normal controls. The APT MTR
asym
values of
MSA
patients in the red nucleus (RN) (SN;
P
= 0.000), substantia nigra (
P
= 0.000), thalamus (
P
= 0.000), and putamen (
P
= 0.013) were significantly higher than those in normal controls. There was a negative correlation between APT MTR
asym
and the score of part III of the Unified Parkinson Disease Rating Scale (
R
= -0.338,
P
= 0.044) in the putamen, while there was a positive correlation between the APT MTR
asym
and the rate of motor symptom progression (
R
= 0.406,
P
= 0.017) in the RN. These findings suggest that APT MTR
asym
changes are found and may be of value in the diagnosis of
MSA
-P.
...
PMID:Changes of Amide Proton Transfer Imaging in Multiple System Atrophy Parkinsonism Type. 3319 64
