Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three cases are reported of attempted termination of pregnancy in which the children were later born with arthrogryposis. These cases were seen at Children's Hospital in Vancouver, British Columbia, Canada. The mothers underwent therapeutic dilatation and curettage during early fetal life (8-12 weeks gestation) in all 3 cases. All children were delivered prematurely (31-32 weeks gestation). They were small for gestational age. The lower limbs were more involved than the upper limbs in all 3 cases. Limb involvement was asymmetrical. Hirsutism was common. In 2 cases, the mothers experienced amniotic fluid leakage. Two cases had anomalies probably due to vascular compromise (scar in patient 1 and abdominal wall defects and bowel atresia in patient 2). Two cases had decreased facial movement. Two cases are functioning surprisingly well. The 16-year-old walks without help, attends high school, and has normal intelligence. The 22-year-old attends college, works in a clerical position, lives independently, and has normal intelligence. Attempted termination of pregnancy likely decreased blood flow to uterine and/or placental blood vessels with possible loss of placental vasculature. The reduced blood flow probably caused fetal hypoxia leading to anoxic injury of tissue and/or blood clots or blockage of blood flow resulting in possible cell death, particularly anterior horn cell death or failure. Inferior anterior horn cell function would likely cause fetal akinesia and secondary multiple joint contractures. Thus, in all 3 cases, it appears that the cause of the contractures is vascular compromise that caused loss of functional neurons with secondary decreased fetal movement.
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PMID:Arthrogryposis associated with unsuccessful attempts at termination of pregnancy. 872 23