Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P50583 (
asymmetrical
)
12,197
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
SNAI1 and
SNAI2
are transcription factors that initiate Epithelial-to-Mesenchymal cell transitions throughout development and in cancer metastasis. Here we show novel expression of SNAI1 and
SNAI2
throughout mouse preimplantation development revealing
asymmetrical
localization of both SNAI1 and
SNAI2
in individual blastomeres beginning at the 2-cell stage through to the 8-cell stage where SNAI1 and
SNAI2
are then only detected in outer cells and not inner cells of the blastocyst. This study implicates SNAI1 and
SNAI2
in the lineage segregation of the trophectoderm and inner cell mass, and provides new insight into these oncogenes.
...
PMID:SNAI1 and SNAI2 are asymmetrically expressed at the 2-cell stage and become segregated to the TE in the mouse blastocyst. 2004 80
