Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A clinical usefulness of computed tomography was reviewed in 38 consecutive patients with subarachnoid haemorrhage and multiple intracranial aneurysms. CT helped in identification of ruptured aneurysm in more than 70% of cases (it pinpointed source of bleeding in 55% of patients and showed region of haemorrhage in 15% of cases). Its main limitation was inability to detect blood in subarachnoid space (SAS) in patients who were diagnosed later after bleeding (23%). Intracerebral haematoma or localized blood accumulated in SAS showed unequivocally the burst aneurysm. Symmetrical and especially asymmetrical distribution of blood in SAS were also helpful, though the former was misleading in two cases. Moreover, CT detected hypodense lesion of brain in 2 cases, widening of ventricular system in 12 patients and directly visualized aneurysm in 3 cases.
 ...
PMID:A clinical evaluation of computed tomography in patients with subarachnoid haemorrhage and multiple intracranial aneurysms. 264 27

An experimental study was carried out on asymmetrical abdominal aortic aneurysm (AAA) to analyse the physiological flows involved. Velocity measurements were performed using particle image velocimetry. Resting and exercise flow rates were investigated in models with rigid and compliant walls to assess the parameters affecting the flow behaviour. The secondary flow patterns, and especially the evolution of the vortices within the AAA, were found to be highly dependent on both the flow waveforms and the wall behaviour. Vortices impacts on the distal walls of the AAA occur in the compliant model and can increase the local pressure on the AAA walls and thus increase the wall stresses; AAA wall stresses are one of the most important factors contributing to ruptured aneurysm.
 ...
PMID:Flow behaviour in an asymmetric compliant experimental model for abdominal aortic aneurysm. 1725 20

To investigate the correlation between the sinus asymmetry and aneurysm rupture. We retrospectively reviewed all diagnostic and therapeutic conventional angiograms of patients with cerebral aneurysms in our hospital from January 2000 to April 2008. Cases were categorized according to gender, presence or absence of aneurysm rupture, and presence or absence of symmetric dural sinuses. Exclusion criteria included patients with underlying fibromuscular dysplasia, dissecting aneurysms, pseudoaneurysms, and the presence of arteriovenous malformations or fistulas. The venous pressure was measured by MR phase contrast with standard fluid dynamics notation as Poiseuille's Law. A total of 193 cases (131 females and 62 males) were included for Chi-squared analysis, which showed significant difference (p < 0.05) between aneurysm rupture and venous asymmetry in the entire group as well as in females, but not in males. There was an association between side of rupture and side of asymmetry as well as between the size of hemorrhage. Ruptured aneurysm is more frequent at the same side of dominant dural sinus than the side of hypoplasia venous sinus. MRA phase contrast is able to show the venous pressure gradient of asymmetrical dural sinuses. With our preliminary data, we propose that dural sinus asymmetry is associated with aneurysm rupture.
...
PMID:Venous hypertension and cerebral aneurysm rupture. 2405 82