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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During 1970-87 43 patients with unexplained pulmonary hypertension (mean pulmonary arterial pressure greater than 25 mm Hg) were admitted to the Brompton Hospital and classified by angiographic criteria as having either symmetrical peripheral pulmonary artery pruning (thought to represent primary plexogenic pulmonary arteriopathy), n = 21, or asymmetrical pulmonary arterial occlusions (thought to represent chronic thromboembolic disease), n = 22. Patients with symmetrical pulmonary arteriopathy had significantly higher mean pulmonary arterial pressures (67 mm Hg) at the time of presentation than those with asymmetrical pulmonary arteriopathy (49 mm Hg). Clinical distinction between these two groups was impossible. Survival from the time of diagnosis was similarly poor in the two groups (26 weeks and 38 weeks) and did not correlate with any of the haemodynamic measurements. The difficulties in making distinctions between these conditions are discussed.
Thorax 1990 Jun
PMID:Clinical correlates of angiographically diagnosed idiopathic pulmonary hypertension. 228 38

The long term results of mitral valve annuloplasty for pure mitral regurgitation are assessed. Thirty-three of the 100 patients (mean age 16 years) had acute rheumatic carditis at the time of operation. Three basic techniques were used: measured asymmetrical annuloplasty (Reed) in 37 patients, posterior plication annuloplasty in 56, Carpentier ring in seven. There were six early deaths, two of which were valve related. The mean follow up period for surviving patients was 4.8 (SD 1.2) years (range 3-9 years). Fourteen patients died late, all but one from valve related causes. Twenty-five had reoperation and all these had mitral valve replacement. The actuarial survival with initial repair was 56% at five years and 42% at eight years. Thirteen patients were lost to follow up. Of the remaining 42 patients, only 27 have an excellent or good clinical result. Eleven patients have only a satisfactory result, with a significant degree of residual or recurrent mitral regurgitation or disability or both. Possible causes of valve related failure were investigated; no significant difference was found between age groups or between acute and chronic cases. Poorer results, of statistical significance, were observed in patients in functional class IV and in those whose operation was performed on an emergency basis. No difference could be found between the results of the three techniques of mitral valve annuloplasty used. This retrospective study indicates that conservative procedures which are limited to annular repair produce inferior results. Valvuloplasty has many theoretical advantages which need practical confirmation.
Thorax 1983 Oct
PMID:Mitral valve annuloplasty: results in an underdeveloped population. 664 51