Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 4-8% of all melanoma patients, a lymph node metastasis develops as the first manifestation of the disease, whereas a primary lesion cannot be found. The latter may have been surgically removed already years ago, may be located at an occult place or - as it is especially characteristic for melanoma - may have vanished spontaneously due to a specific immunological mechanism. Such spontaneous tumour regression, which, for instance, becomes recognisable by the development of a halonaevus or an asymmetrical vitiligo, does not imply an improvement of the individual prognosis. However, present knowledge suggests that in patients with unknown primary lesion neither an adjuvant chemotherapy nor immunotherapy can be recommended, if the metastasis has been surgically removed completely. Additional radiotherapy does also not appear to be indicated. Only a short-interval follow-up remains important.
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PMID:[Melanoma metastasis in the neck region with unknown primary tumor]. 670 Mar 27

We report an unusual manifestation of vitiligo colocalizing with lichen planus (LP). A 76-year-old Greek male presented with a history of a red, scaly, itchy, asymmetrical patch located at the umbilicus within a well-demarcated depigmented macule of vitiligo. Histology showed features of a lichenoid interface dermatitis, favouring a diagnosis of LP. Colocalization of LP and vitiligo has rarely been reported in the literature. After reviewing the literature, we believe that at present there is insufficient evidence to resolve the uncertainties in the aetiology of this colocalization. It seems to us that the association between LP and vitiligo is more than coincidental, but none of the theories discussed in this paper can sufficiently account for it. Rather, the association is likely to be multifactorial in its pathogenesis.
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PMID:A Rare Colocalization of Lichen Planus and Vitiligo. 2668 60