Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A new technique of individual, three-dimensional (3-D) planning and transferring this to craniofacial operations is reported. The combination of an individual model of the skull of the patient with a transfer device enables planning of real 3-D surgery. The surgical technique is demonstrated in a case with an asymmetrical midface and mandible after ankylosis of the TMJ in childhood.
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PMID:Three-dimensional craniofacial surgery: transfer from a three-dimensional model (Endoplan) to clinical surgery: a new technique (Graz). 161 8

We have been treating a girl with hemifacial hypertrophy since she was 5 years 8 months old. We analyzed her stomatognathic function, the dentition and occlusion, X-ray findings of TMJ, tooth contact and measurements of mandibular movement, at 9 years 2 months. The results were as follows: 1. The maxillary dental arch was almost symmetrical, but the mandibular one was complicatedly distorted in the up and down directions, and largely shifted to the left side. As a result the patient was able to occlude in the severe cross-bite condition of the area from incisors to left molars. 2. The patient had many tooth contact points on the right side and few on the left side when she bit at the intercuspal position and at the both lateral excursions. 3. From the analysis of the mandibular movements on the protrusion, lateral excursion and maximum open and close positions, it was suspected that the shift of right condyle was much less than the left one, and showed as almost rotating movement. 4. It could be concluded that the patient was accustomed to having more tooth contacts in the right dentition than in the left one because of the hypertrophy of the right half of mandible, so that she could only masticate with the right teeth also the anterior displacement of disk with reduction was resulted on the right condyle and the asymmetrical mandibular movement was noted.
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PMID:[The stomatognathic function in a case of hemifacial hypertrophy--findings of mandibular movement]. 178 63

Evaluation for signs and symptoms of TMJ disturbances during childhood and early adolescence is important. Early occlusal treatment for mandibular asymmetries may reduce temporomandibular joint growth site pathofunction, thus resulting in less pain, headache, and asymmetrical development of the mandible.
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PMID:Acquired condylar hypoplasia: report of case. 205 Aug 75

We encountered three patients with TMJ dysfunction syndrome in adolescents whose mandibulars were asymmetrical. In two cases, we tried to treat with EMG Biofeedback therapy in order to improve a form and function. The following results were obtained from the progress and result of the treatment. Asymmetry of mandibular causes the functional disharmony of masticatory muscle and it is probable that its asymmetry causes TMJ symptoms. These symptoms are improved with an occlusal splint, occlusal adjustment and occlusal reconstruction. The form does not change with the EMG Biofeedback therapy which is used in order to activate the masseter muscle. The function changed but was not stable.
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PMID:[Three cases with temporomandibular joint dysfunction syndrome in adolescents whose mandibular are asymmetrical]. 260 4

A three-dimensional condylar analysis of the ICP relative to the RCP was completed for 75 patients by using a system of styli adapted to an arcon articulator. The recorded sagittal condylar positions were seen in three of the four quadrants, the posterior-superior quadrant was devoid of registrations. The percent of registration was approximately equal for the right and left sides; anterior-inferior quadrant, 60%; posterior-inferior quadrant, 30%; and anterior-superior quadrant, 10%. Midcondylar value of the ICP presented the smallest standard deviation but the data concerning condylar position were unreliable because symmetrical and asymmetrical movement may produce similar midcondylar values. Seventy-two percent of the anterior-posterior and 45% of the superior-inferior condylar ICP recordings of patients fell within the range of a dentally healthy sample of young men. Only 2% of recordings the patients were outside this range in a superior direction. These data were nearly equal numerically for the right and left sides and conformed to the anatomic freedom of TMJ. Slightly more than 57% of the sample had an MLD greater than 0.3 mm compared with a dentally healthy sample. There was a 42% greater incidence of skew greater than 0.7 mm and a 22% greater occurrence of tilt greater than 0.7 mm in the dental patient sample, compared with the findings of Hoffman et al. An index ICP asymmetry was proposed that indicates the relative value of skew and tilt in a single quantitative factor. Three mandibular movements were identified, skew and tilt with angular components and MLD, translation. These three movements have 3 degrees of freedom, right or left movement or no movement, resulting in 27 permutations. The combination of these elements make it difficult to determine condylar position from occlusal midline observation.
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PMID:Condylar retruded contact position and intercuspal position correlation in dentulous patients. Part I: Three-dimensional analysis of condylar registrations. 346 49

We introduce a new method of analysis of the normal and abnormal behavior of the TMJ, using a duplex-doppler spectral analysis. The method consists in monitoring the joint movement by means of a study of the Fourier transformed signals, which give information on the velocity distribution of the condylo-meniscal complex during the opening and closing phases of the jaw. Using repeated sampling over short time intervals we get a detailed description of the motion which allows to discriminate the normal and abnormal action of the condylomeniscal complex. We are able to identify various physiopathological conditions, among which opening and/or closing clicks, complex locking conditions and anomalies related to an asymmetrical behavior during the operation cycle. Duplex-doppler spectral analysis is correlated to a clinical examination in order to define various classes of anomalies.
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PMID:Duplex-Doppler spectral analysis in the physiopathology of the temporomandibular joint. 815 35

Patients with chronic facial pain including those with facial arthromyalgia (TMJ dysfunction syndrome) were investigated for evidence of abnormal systemic and intra-articular free radical activity. Chronic facial pain patients showed significantly raised serum 2,3-dihydroxybenzoic acid after an oral dose of 1.2 g of aspirin which indicates increased systemic free radical activity. This was reflected in the TMJ aspirates of the facial arthromyalgia patients which contained thiobarbituric acid-reactive substance (TBA-RS) which is also a product of free radical activity. The synovial aspirates also contained high levels of the hyperalgesic eicosanoid 15-HETE. However, there was no difference between the painful and symptom-free joints, which suggested that in part the clinical features are probably determined by asymmetrical masticatory function or as yet unknown algesic factors such as local cytokine production.
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PMID:The role of oxygen free radicals in idiopathic facial pain. 921 90

From an orthodontic point of view, asymmetries can be gathered in three great clinical entities: mandibular lateral deviations, dental asymmetries without skeletal involvement, skeletal asymmetries. Once the therapeutic aims and the principles of the orthodontic approach of these dysmorphoses have been recalled, the authors present the various orthodontic means implemented in this type of treatment. Four cases treated illustrate those types of treatment. Vertical non-surgical asymmetry may have an obvious local origin, for instance, a unilateral damage to a nerve. but usually, there is no evident origin. Frequently the occlusal slippage of a severe sagittal or a vertical malformation, which may evolve as a borderline surgery case, is suspected to be the real cause. In these cases, the diagnosis is always late, with the ending growth. The treatment needs peculiar strong asymmetric mechanics and, sometimes, unilateral mixed extractions. The post-treatment occlusion can be unstable; for this reason, the finishing steps must be carefully conducted. Four clinical case reports develop these points ov view. Multidisciplinary treatments prove very useful to solve three types of clinical situations. In the adult patient, facial esthetics are indicated in severe dentofacial asymmetries. Esthetic improvements of dental nature are still required in deviated smiles, or frontal tippings of the occlusal plane. In addition, asymmetrical intermaxillary relationships will lead to functional anomalies: TMJ disorders, dental wear or lingual dysfunctions. Finally, multidisciplinary treatments in the adult concern the occlusal transverse anomalies, the lateral crossbites, the Class II subdivisions, the deviations of the inter-incisor midlines or unilateral edentulousness. The various plans of treatment, as well as the orthodontic mechanics used, are illustrated in the following development by clinical cases.
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PMID:[Orthodontic approach to asymmetry]. 1206 70

The aim of the study was to assess the relationship between vertical skeletal pattern in terms of mandibular rotation and osseous structural changes of the TMJ in pre- surgical orthognatic patients. TMJ skeletal morphology was evaluated in cone beam computer tomography images of 117 consecutive patients with Class II and Class III dentofacial deformities according to the research diagnostic criteria of the osseous components of the TMJ related to the maxillary-mandibular plane (MM) angle. The distribution of the number and percentage of joints with structural changes in Class II was markedly different in groups divided according to the MM angle. Statistically significant increase was found in the percentage of TMJ's with osseous changes separately for each side, i.e., right (p=0.001), left (p=0.04) and both together (p=0.0001), in the Class II patient group, an increased MM angle indicated backward rotation of the mandible. In Class III patients, there were no statistically significant differences in the number of joints with TMJ structural changes. The presence of mentioned changes was asymmetrical between the left and right joints in both the Class II and Class III patient groups. In conclusion, structural changes in the osseous parts of the TMJ are more common in patients with Class II skeletal dentofacial deformities with backward rotation of the mandible than in Class III pre-surgery orthognathic patients.
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PMID:The relationship between mandibular rotation and osseous structure of the TMJ in pre-surgery orthognathic patients: A cone beam CT study. 2687 68

Background: The pterygoid fovea on the mandibular neck is superomedial to the mandibular notch and serves to attach the lateral pterygoid muscle. Clinical presentation: During a retrospective cone beam computed tomography study, a 67-year-old male patient was found to exhibit a peculiar variant that contradicted normal anatomy. The patient's mandibular condyles were asymmetrical in terms of their shapes and sizes, although their lateral poles (lateral condylar tubercles) were both prominent. On the left side, the lateral condylar tubercle had a second, or accessory, pterygoid fovea, which was located outside the mandibular notch. Further, the left lateral pterygoid muscle was attached to the entire width of the mandibular condyle, including the accessory fovea. Clinical significance: Such rare anatomical variants lead to asymmetrical temporomandibular joints, although their occurrence has not previously been reported. Thus, they should be further documented in clinical studies of temporomandibular joint dysfunction. Abbreviations: LPM: Lateral pterygoid muscle; MC: Mandibular condyle; PF: Pterygoid fovea; TMJ: Temporomandibular joint; MCC: Mandibular condylar cartilage; MPR: Multiplanar Reconstruction; VC: Vascular canal.
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PMID:Accessory pterygoid fovea of the human mandibular condyle. 3124 Oct 1


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