Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This paper represents an analysis, accomplished over an eight-year period, of 90 individuals who have been operated on for various arthritic diseases of their temporomandibular joints (TMJ). In arthritic changes of the joint, several changes may occur: perforation of the disc, flattening of the articular eminence, asymmetrical condylar movement, and chronic synovitis. This may result in increased synovial pressure on nerve fibers within the capsule of the joint, and a variety of referred pain symptoms. Prior to operation, a careful differential diagnosis was made by an otolaryngologist and, frequently, by a neurologist/neurosurgeon and a psychologist. The prosthesis inserted during surgery was a metallic device which fits over the articular eminence in the upper portion of the joint. This prosthesis accomplished primarily three functions: elimination of the crepitus; restoration of the contour of the eminence; separation of the articular surface of the joint.
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PMID:Clinical evaluation of TMJ arthroplasties with insertion of articular eminence prosthesis on ninety patients (an eight year study). 87 84

Seven cases with the syndrome of thalassemia minor and pauciarticular, non-erosive, seronegative arthritis are described. Other known causes of seronegative arthritis had been excluded. There was a predilection for middlesized joints such as ankles, wrists and elbows. Usually the synovitis was asymmetrical from onset, with one to eight joints affected. Finger or toe joint were usually spared. Extraarticular synovitis such as tenosynovitis or bursitis were not observed, nor were nodules, signs of vasculitis or visceral involvement. The course of this arthritis showed chronicity and mild, persistent, non-erosive synovitis without joint effusions. X-ray revealed juxtaarticular osteoporosis of the affected joints, characterized by a diminution of the number of trabeculae (hypertrophic atrophy) combined with broadening of the singular trabeculae; this picture is typical of hemoglobinopathies. - Computed tomography showed a probable slight deficit of bone mineralization. Laboratory investigations including ESR, routine immunological tests, blood chemistry, and HLA-tissue typing were all normal. - The combination of this peculiar arthropathy with thalassemia minor would appear to be worthy of note and requires a further search among the forms of arthritis of unknown origin.
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PMID:[Arthritis in thalassemia minor]. 89 52

Twelve patients had undiagnosed articular disease associated with type IV hyperlipoproteinemia. Objective joint findings involved both large and small joints. Disease was bilateral but asymmetrical and oligoarticular. Synovitis was midly inflammatory and persistent rather than episodic in natrue, and disability was minimal. Serial slinical, laboratory, and radiographic assessment excluded other currently recognized forms of rheumatic disease. Joint radiographs demonstrated large metaphyseal and epiphyseal cysts in five patients. Synovioanalysis and synovial biopsy results are reported in two patients. These cases appear to constitute a clinically homogeneous group. The concurrence of a distinctive articular syndrome and type IV hyperlipoproteinemia suggests a possible causal relationship.
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PMID:Polyarthritis associated with type IV hyperlipoproteinemia. 114 32

The wrist is frequently involved in the course of inflammatory rheumatism. The clinical and radiological features of the arthritis may guide the diagnosis when wrist involvement is isolated. The rheumatoid wrist may associate articular and tendon sheath synovitis, nerve compressions, muscle atrophy and deformities. X-rays reveal increased volume of the soft tissues, followed by cartilaginous destruction. Magnetic resonance imaging may detect the lesions early in their course. RS3PE, rheumatoid arthritis of the elderly, never induces destructive lesions. Still's disease is distinguished from rheumatoid arthritis by the predominant involvement of the radiocarpal and intercarpal joints with relative sparing of the metacarpo-phalangeal and proximal interphalangeal joints. Jaccoud's hand may be observed in the course of lupus with metacarpo-phalangeal dislocation of capsulo-ligamentous origin without cartilaginous destruction. Wrist involvement is often asymmetrical in ankylosing spondylitis. In psoriatic rheumatism, arthritis of the wrist is similar to that observed in rheumatoid arthritis, but demineralization is less common and occurs later and constructive lesions are associated with pinching.
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PMID:[Rheumatic wrist]. 128 5

The coincidence of arthritis with polymyalgia rheumatica (PMR) or temporal arteritis (TA) is not well established. After reviewing the literature we found that 22% of patients suffering from PMR/TA present with additional signs of inflammatory joint involvement. Joints predominantly affected are the sternal junctions, knee and shoulder joints, and the wrists, involvement of the latter frequently resulting in carpal tunnel syndrome. With the exception of sternal junctions, bony erosions are rarely seen. In most cases, synovitis is mild, pauciarticular, asymmetrical, transient and not destructive. Little evidence for inflammatory involvement of spine or sacroiliac joints was found, thus, back pain in these patients should be considered as caused by osteoporosis of the spinal column, mostly due to prolonged corticosteroid treatment.
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PMID:[Joint involvement in polymyalgia rheumatica/temporal arteritis]. 265 37

Recurrent episodes of seronegative asymmetrical arthritis usually lasting less than a week have been observed in 4 patients with beta thalassemia minor. In one case, irreversible joint damage of a wrist joint occurred 14 years after the onset of the rheumatism. Studies of the synovial fluid and synovial membrane performed in 2 cases revealed signs of moderate inflammation. The main differential diagnosis was from microcrystalline synovitis and palindromic rheumatism which was ruled out by clinical and laboratory data.
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PMID:Recurrent episodes of arthritis in thalassemia minor. 661 Jul 57

The aim of this survey was to determine the vascular disturbances occurring during transient synovitis (observation hip, "hanche irritable"). Within these last two years thirty children were admitted with painful hip, limp and restriction of the passive motion in the hip joint. Legg-Calve-Perthes disease was excluded by roentgenographic analysis and bone scintigraphy. Osteoblastosis was studied by using 99mTc methyl-diphosphonate. Another tracer was necessary to investigate the blood supply into the affected femoral head : 99mTc marked colloids were injected. Immediately after the intravenous administration of the isotope comparative activity was recorded every ten seconds. Computerized information allowed the description of four different stages, i.e. arterial supply, filling peak, venous elimination and later recirculation. Nineteen (63%) affected children presented a decrease in isotopic activity during the first two stages. The proposed interpretation consists in a selective decrease in blood supply in the femoral head. Venous circulation was rarely disturbed. Treatment consisted in bedrest with skin traction. In this series, no aspiration of the joint was performed. Eight days after admission dynamic scintigraphy with marked colloids revealed a highly significant decreased asymmetry between the two femoral heads. Only seven patients (23%) presented arterial hypoperfusion. Fifteen days later only three cases remained abnormal. Two of them presented some weeks after the regression of the symptoms an asymmetrical bone scintigraphy and secondarily the roentgenographic features of Legg-Calve-Perthes disease. Radioactive colloids seem to be useful to diagnose transient synovitis and to determine the prognosis. Although its etiology is still unknown, transient synovitis seems to be characterized by vascular disturbances consisting in a decrease in blood supply in the affected femoral head. Persistence or recurrence of abnormal colloid scintigraphy is indicative of a poor prognosis.
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PMID:[Vascular disorders in irritable hip disclosed by dynamic scintigraphy with radioactive colloids]. 717 48

The authors report the case of a 49-year-old woman with an asymmetrical, seronegative and peripheral polyarthritis with erosions, who subsequently developed Crohn's disease. She was diagnosed as having an erosive Crohn polyarthritis as no evidence of rheumatoid arthritis was found. However, the patient was homozygote for DR4 and the HLA DRB1 oligotyping was 0401/0404. This corresponds to two susceptibility alleles for rheumatoid arthritis responsible for the severity of this disease. Erosive polyarthritis is rarely encountered in inflammatory bowel diseases. The underlying mechanism of the erosions in these conditions is unknown but granulomatous synovitis with contiguous erosive bone changes has been reported. HLA DR has not been previously reported in erosive Crohn polyarthritis. The homozygosity for DR4 with DRB1*0401/0404 subtypes suggests that DR4 could contribute to the erosive course in this patient. This question is of interest, and HLA DR must be further studied in inflammatory bowel diseases with erosive arthritic manifestations.
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PMID:Erosive polyarthritis and Crohn's disease. A case with HLA DRB1 determination. 765 74

From two studies (Lambert et al, 1976; Shore and Ansell, 1982), it was concluded that juvenile psoriatic arthritis is a distinct entity with one group of patients virtually indistinguishable from those with juvenile chronic arthritis initially, while all the patterns of psoriatic arthritis recorded in adults were seen in the remainder. A family history of psoriasis occurs in about half the patients, and one of arthritis in 20%. A swollen tendon sheath of a single finger or toe associated with synovitis in two or three joints of the digits is highly characteristic. Accurate diagnosis is important because these patients tend to go on to develop an asymmetrical destructive polyarthritis. This needs to be recognized early to utilize effective slow-acting drugs. Southwood and colleagues (1989) have defined two quite distinct groups of juvenile psoriatic arthritis: those young at onset, who are usually girls, and those in adolescence, who are more frequently boys. It is possible that there are other variants, including girls aged 8-10 years with a polyarthritic onset who may go on to develop arthritis mutilans. The concept of 'probable juvenile psoriatic arthritis' is supported by follow-up, in that a significant proportion of such patients do pass into the definite group. It is highly desirable that the suggested Vancouver criteria are validated by a long-term prospective study, which will probably need to be multicentred to ensure that the subgroups are large enough for satisfactory conclusions to be drawn. In the management of this serious arthritis in childhood, it is important to consider long-acting drugs early, before undue damage to joints has occurred. Again, multicentre studies are needed to determine which is the most useful. Presently, methotrexate appears to be the drug of choice.
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PMID:Juvenile psoriatic arthritis. 807 90

Psoriasis usually occurs many years before development of arthritis. This is a case report of a patient with acute polyarthritis affecting both peripheral joints and the left sacroiliac joint, preceding the appearance of typical skin manifestations for almost two months. A 44-year-old male mechanic was admitted to our institution for acute additive polyarthritis. Inflammatory synovitis primarily affected large peripheral joints (knees, ankles) in an asymmetrical pattern, with a concomitant development of unilateral sacroiliitis and later with asymmetrical involvement of several proximal and distal interphalangeal joints of the hands and feet. There were also signs of enthesopathy of the right heel. Arthritis was not proceeded by infection of the lower genital or gastrointestinal tract or serological and bacteriological evidences of streptococcal or HIV infection. Laboratory findings showed an erythrocyte sedimentation rate (92 in the first hour), positive histocompatibility antigen HLA-B27 and an increased level of acute phase reactants. Almost two months after affecting the locomotor system a typical psoriatic rash developed, first affecting the scalp and then spreading over the trunk and extremities. It was accompanied by severe onychodystrophy. The patient underwent intensive treatment with methylprednisolone (1.5 mg/kg) and cyclosporine A with significant results.
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PMID:[Psoriatic arthritis: case report of acute HLA-B27 positive polyarthritis preceding the onset of typical skin changes]. 947 36


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