Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sixty-six consecutive patients without left ventricular volume overload, significant arrhythmia or significant pericardial effusion were examined by M-mode echocardiography immediately before diagnostic left- and right-heart catheterization. Using various echocardiographic measurements, left ventricular stroke volume (SV) was calculated according to eight different echocardiographic formulas (SVE) that have been proposed previously. At catheterization SV was also determined by thermodilution (SVT) and by single-plane left ventricular cineangiography in the right anterior oblique projection (SVA). When comparing SVE with SVT, the four formulas developed to calculate mitral or aortic flow failed (r = 0.10 to 0.54). As expected, poor correlations (r = 0.22 to 0.47) were also found when formulas used to calculate ventricular volumes from the ventricular diameter or SV from the change in diameter (left ventricular formulas) were used in coronary patients with grossly asymmetrical ventricular contraction patterns. When the use of the left ventricular formulas was confined to patients with symmetrical or almost symmetrical contraction, two formulas yielded favorable correlations of r = 0.84, SEE = 12.7 ml and r = 0.86, SEE = 12.2 ml, respectively. These correlations were comparable to the correlation between our two invasive reference techniques (r = 0.81; SEE = 12.2 ml). The comparison between SVE and SVA confirmed the results of the thermodilution study, though the correlations were generally weaker. We conclude that the formula of Teichholz et al., which was the best of all tested formulas, may be used to obtain a clinically useful estimate of SV in patients in whom symmetrical or almost symmetrical left ventricular contraction can be anticipated.
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PMID:Comparative value of eight M-mode echocardiographic formulas for determining left ventricular stroke volume. A correlative study with thermodilution and left ventricular single-plane cineangiography. 49 56

Serial electrocardiograms as well as echocardiographic studies of 51 pilgrims suffering from acute heat stroke (mean rectal temperature 41.6 degrees C) were performed. All patients were examined immediately after cooling and 24 h later whenever possible. Regional wall motion abnormalities were detected in 9 cases (17.6%) while pericardial effusion was observed in 13 cases (25%) and asymmetrical septal hypertrophy was detected in 8 cases (15.6%). Other cardiac abnormalities included right ventricular dilatation and increased in left ventricular internal dimensions in 4 cases (7.8%), respectively. Thirteen cases (25.5%) had normal echocardiographic findings. Forty (78%) patients had sinus tachycardia while 8 cases (15.7%) showed atrial fibrillation with uncontrolled ventricular rate, and 3 (5.8%) had sinus bradycardia. Heat stroke electrocardiograms showed tracings demonstrating ST segment depression, compatible with ischaemia in 9 cases, while in 6 cases there were nonspecific T wave changes, whereas in another 4 cases the tracings demonstrated different conduction abnormalities. The collected data were analysed and compared to those of 43 control patients. The adverse effects of heat stroke on the heart are multifactorial requiring the utmost attention and understanding, as they reflect the patient's cardiovascular status.
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PMID:Non-invasive evaluation of cardiac abnormalities in heat stroke pilgrims. 145 70

A woman having common migraine attacks coincident with an asymmetrical bilateral occipital lobe infarction that spared the brainstem and cerebellum underwent these studies: serial electroencephalography, brainstem auditory, visual and somatosensory evoked potentials, magnetic resonance imaging of the brain and cerebral arteriography. The patient's vision improved greatly during a one-year follow-up. The absence of risk factors for stroke suggested that migraine caused the infarction in the posterior circulation network. The pathophysiological mechanisms of stroke in migraine remains speculative.
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PMID:Bilateral occipital lobe infarction in acute migraine: clinical, neurophysiological, and neuroradiological study. 152 69

Two patients with bilateral anterior cerebral artery (ACA) territory infarction are presented whose initial diagnosis was basilar artery occlusion. Both had tetraparesis; in one it was asymmetrical. Both had their eyes open and did not respond to command except that after a delay they followed with their eyes a smoothly moving object; this was the only sign of awareness. One patient had a clear vertical gaze palsy in the upward and downward direction unaccompanied by pupillary abnormalities. Computed tomography revealed fresh bilateral ACA infarction in both patients; occlusion in the hind brain circulation was excluded by angiography in one. Both patients suffered from atrial fibrillation, so cardiac embolism was the most likely cause of the stroke. We conclude that bilateral ACA territory infarction should be considered in the differential diagnosis of basilar artery occlusion, even if accompanied by vertical gaze palsy.
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PMID:Bilateral anterior cerebral artery territory infarction in the differential diagnosis of basilar artery occlusion. 849 18

Rapid changes in national rates, with little evidence of cohort effects, must substantially reflect changes in incidence rates due to socioeconomic and behavioral influences, operating with a rather short incubation period. Every newly-rich society usually experiences its epidemic of coronary heart disease. Rate changes for men and women are correlated, but the regression is asymmetrical: greater falls in women seem to reflect some rather uniform widespread sex-specific change, on top of which is another and highly variable factor common to both sexes. Trends are correlated with diet (especially with the constitution of fats). A correlation with stroke trends suggests a common link with population changes in blood pressure, in which obesity may play a part. Other important influences on population trends and differences remain unidentified or unconfirmed.
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PMID:Causes of the trends and variations in CHD mortality in different countries. 280

Routine pharmacological screening of thiourea compounds led to the selection of pyridyl cyanoguanidines for their antihypertensive effects. From this cyanoguanidine class of compounds, P 1134 (pinacidil) was synthesised. Pinacidil has an asymmetrical carbon atom in the pinacolyl radical and the (-) enantiomer is more active than the (+) enantiomer both in vitro and in vivo. Pinacidil is rapidly absorbed following oral administration with the time to peak plasma concentration being 0.5 to 1 hour and, for the extended release formulation, 1 to 3 and 5 to 7 hours. The antihypertensive effect of pinacidil is proportional to the dose administered. Pyridine-N-oxide is the principal metabolite and accounts for approximately half of the dose excreted in the urine within 24 hours. In hypertensive rats and dogs, the blood pressure-lowering effect of pinacidil is dose-dependent and linearly related to the baseline blood pressure. The haemodynamic profile is characterised by an increased cardiac output as a consequence of increased stroke volume. An increase in heart rate follows the depressor response. The fall in blood pressure is preceded and superseded by a fall in the total peripheral resistance. Preclinical haemodynamic studies suggest that pinacidil is a directly acting precapillary vasodilator. The resting membrane potential of smooth muscle cells is approximately -60mV whereas the equilibrium potential for potassium is more negative, between -80 and -90mV. Pinacidil opens K+ channels and allows potassium to attain its equilibrium potential, resulting in hyperpolarisation of the cell at rest. A hyperpolarised cell is less prone to depolarisation, and without depolarisation there is no activation of the voltage-operated Ca2+ channels and, hence, no muscle contraction.
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PMID:Pinacidil. Preclinical investigations. 307 34

Six hundred and sixty-one patients with stroke, confirmed by CT scan or at autopsy, were reviewed in order to evaluate the frequency of presentation with altered mental state. Nineteen patients (3%) had presented with delirium, an organic delusional state, the acute onset of dementia, or mania, mimicking psychiatric illness. All had focal cerebrovascular lesions which were usually, but not invariably, right sided. None had a previous history of cognitive impairment, psychiatric disease, drug abuse, or alcohol excess. Neurological signs were absent or mild and transient, and therefore easily missed. Post-mortem examinations in four patients showed localised cerebral infarctions with no evidence of multiple lesions, Alzheimer's disease, or metabolic encephalopathies. The possible causative factors are discussed and the evidence of asymmetrical cerebral representation of emotion, and for a relationship with epilepsy, is reviewed.
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PMID:Inobvious stroke: a cause of delirium and dementia. 347 Nov 94

Acute occlusion of one common carotid artery in the anesthetized normocapnic rat results in a moderate cerebral blood flow (CBF) decrease in both cerebral hemispheres. No asymmetrical perfusion is observed when the overall flow in each hemisphere is considered. The increase in blood flow which normally occurs in hypercapnia is strongly impaired in the cerebral hemisphere on the occluded side resulting in an important asymmetrical hemispheric perfusion. The days (1, 5, 15, 30) following unilateral carotid occlusion normal control CBF values are found in both hemispheres in normocapnic conditions. Hemispheric perfusion asymmetry in hypercapnia also becomes progressively less pronounced with time but a slight asymmetry still persists one month after unilateral carotid occlusion.
Stroke
PMID:Hemispheric blood flow in the rat after unilateral common carotid occlusion: evolution with time. 396 69

Capping structures at the distal tips of frog palate cilia are attached to the A- and central pair microtubules by electron-dense plug structures similar to those found in protozoan cilia and flagella and in epithelial cilia from invertebrates and vertebrates (W.L. Dentler, 1980, J. Cell Sci. 42, 207-220; W.L. Dentler and E.L. LeCluyse, 1982, Cell Motil. 2, 549-573). The caps in frog palate cilia are composed of a proximal shelf, to which doublets Nos. 1-3, 8, 9 and the central microtubules are attached and a larger distal cap to which doublets Nos. 4-7 are bound. The smaller proximal shelf is positioned to one side of the cilium and gives the cap an asymmetrical appearance. Striated ciliary rootlets attached to the basal bodies are also described. The smaller cap is placed on the same side of all cilia on the palate relative to both the direction of the effective stroke and the position of the rootlets. These results confirm that capping structures are common to most, if not all, cilia and provide direct evidence that they are precisely positioned on specific microtubules.
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PMID:Asymmetrical microtubule capping structures in frog palate cilia. 673 61

In this study, the intensity of the asymmetrical tonic neck reflex (ATNR) was measured in post-cerebrovascular accident (CVA) adults with hemiplegia and in neurologically intact adults to determine if the reflex exaggerated following CVA. Fourteen subjects with right and left hemiplegia were matched to neurologically intact subjects by age and sex and tested for the ATNR. Intensity of the reflex was measured using electromyography (EMG) biofeedback. The results indicate that no difference exists between the two groups in intensity of the reflex. The method of rotation used to elicit the reflex did significantly affect the strength of the muscle response. A possible explanation for observation of the reflex in the hemiplegic individual's movement and its significance in neuromuscular re-education programs is discussed.
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PMID:A comparative study on the presence of the asymmetrical tonic neck reflex in adult hemiplegia. 674 88


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