Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty two strabismus and 106 straight eyed patients with anatomically normal eyes were first photographed with a conventional camera equipped with a weak 100 mm teleobjective and coaxial flashlight and then examined clinically. The possibility of detecting strabismus, anisometropias and ametropias in the photographs by noting the localisation of the corneal reflexes and examining the appearance and lightness of the fundus reflexes and their possible asymmetry were tested in a double blind study. Even small angled strabismus cases could be found because of the asymmetrical localisation of the corneal reflexes. In 18 of the 22 strabismus cases (82%) there was asymmetrical lightness of the fundus reflexes and the fundus reflex of the deviating eye was lighter than that of the fixating eye. All the straight eyed anisometropias of 3.0 diopters or more (five cases) were observed in the photographs because of the asymmetrical appearance of the fundus reflexes. In straight eyed anisometropias of under 3.0 diopters, the fundus reflexes were symmetrical in 90 cases and asymmetrical in 11 cases (11%). Only three out of eight hyperopias of fomr +4.5 to +6.0 diopters were found because of the light crescent in the low part of the pupil. All myopias of over -4.0 diopters (14 cases) were observed because of the light crescent appearance in the upper part of the pupil. No pupillary crescents appeared with refractions of less than -1.75 diopters myopia or less than +4.5 diopters hyperopia; 172 eyes came within this range. Even a technician can perform, without premedication, the method tested here for rapid and simple screening to detect strabismus and straight eyed anisometropias of 3.0 diopters or more in small children or other patients who do not co-operate well in normal clinical examination. Over -4.0 diopters myopias can also be found. The method was rather unreliable for finding hyperopias, presumably because no cycloplegic drops were used.
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PMID:A clinical study on the detection of strabismus, anisometropia or ametropia of children by simultaneous photography of the corneal and the fundus reflexes. 52 83

A total of 45 patients with craniopharyngioma are reviewed, with particular reference to the presenting clinical features and neuro-ophthalmological findings. Of these 50 per cent had been referred in the first instance to an eye clinic. More than half the children presented with the clinical picture of raised intracranial pressure, although one-third of these had optic atrophy rather than papilloedema. One-third of the children had a history of concomitant strabismus, and only one patient had a paretic squint. The majority of the adults presented with visual failure and optic atrophy. Bitemporal hemianopia was fairly frequently found (27 per cent of our patients at the time of diagnosis) but was asymmetrical and unpredictable in its evolution. Homonymous hemianopia was relatively common, a presenting feature in II per cent of patients in this study. Full fields were found initially in nine patients (20 per cent), a high incidence compared with pituitary adenomas or suprasellar meningiomas. We consider pleomorphism, that is a distinct change from one type of field defect to another with progress of the disease, to be a characteristic feature of the tumour (as indeed are fluctuations in the clinical state and visual acuity); it was detected in 22 per cent of our patients. Endocrine disorders were common, especially in adults, and mental deterioration was a frequent presenting feature in patients over 30 years of age. Straight x rays of the skull are practically diagnostic of craniopharyngioma in children, but in adults a normal x ray does not exclude the diagnosis.
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PMID:Eye signs in craniopharyngioma. 76 25

The asymmetrical deformities in 20 children with various types of cerebral palsy are compared with 20 children without cerebral palsy who have the so-called 'squint' baby syndrome (asymmetrical deformities of plagiocephaly, unilateral bat ear, facial and thoracic asymmetry, pelvic obliquity and apparent shortening of one leg). It is suggested that the 'squint' baby syndrome and the 'windswept' child syndrome in children with cerebral palsy are stages of the same syndrome and that in both the deformities are caused by the effect of gravity on an immobile growing child, rather than spasticity or muscle imbalance. Asymmetrical deformity should therefore be amenable to physiotherapeutic intervention, rather than trying to modify maturation of the damaged brain. As the 'windswept' cerebralpalsied child can develop some of the most severe deformities seen in cerebral palsy, it is important that asymmetrical deformities should be prevented.
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PMID:Position as a cause of deformity in children with cerebral palsy. 1848 54

A 46,XX,del(10)p13 karyotype (Paris Conference, 1971) was identified in a 5-year-old Negro girl with mental and growth retardation, brachy- and trigonocephaly, downward slanting palpebral fissures, hypotelorism, epicanthal folds, ptosis, strabismus, dysplastic nose, high-arched palate, microdontia, small low-set posteriorly rotated ears, asymmetrical thorax, wide-spaced nipples, and minor abnormalities of hands and feet. Both parents and a brother had normal karyotypes. Expression of more than 50 polymorphic gene loci determining blood groups, serum proteins and red cell enzymes was studied. The results did not permit localization of a gene locus on the deleted segment of chromosome 10. The proposita was heterozygous for the Rh and MN blood groups and for the red cell enzymes adenosine deaminase, glutamate pyruvate transaminase and esterase D. These gene loci are thereby excluded from region 10p13 yields 10pter.
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PMID:Del (10)p autosomal deletion syndrome: clinical, cytogenetic and gene marker studies. 115 Feb 32

The manual and visual dominance of one side has in recent times attracted much attention from many aspects. Crossed dominance (right eye - left hand) seems significant in strabismus of childhood. For the first time recently it has become obvious, that the structure of the body and its muscles, especially of the trunk is asymmetrical. Even in normal persons the centre of gravity of the body is not in the midline, but displaced usually some distance to the left. We have examined the stabilographic proportions in 30 normal and 30 squinting children. In the normal children, with closed eyes the centre of gravity of the body was displaced in 80% to the right, in the quinting children this point was in 73% displaced to the left. We can deduce from this, that the marked right-eye dominance in squinting children is responsible for the displacement of the centre of gravity. If the right eye is open, then the vertical body-axis tends a little to the left. This tendency demands an increase of muscle tone on the left side of the body and with this a displacement of the body centre of gravity to the left; this not only, when the right eye is open, but also, when both eyes are opened or closed. From our experience this adjustment is especially suited to normalise the working together of the hand and the eye in squinting children.
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PMID:[The problem of crossed eye-hand dominance (author's transl)]. 124 May 48

Exencephalic tail-short (Ts/+) embryos were obtained from mating normal mice of Patch strain with Ts/+ mice from Babl/c strain. The most common eye malformations in the exencephalic embryos were exophthalmy, microphthalmy, eye ball irregularity and corneal opacity. Squint eye and unilateral anophthalmy occurred at a lower frequency. The eye abnormalities were recognized histologically by 11-days of gestation. The retina was retarded in development. Lens fibres were swollen and some of them appeared degenerated. Lens epithelium was protruded anteriorly, detached from the underlying lens and joined the corneal endothelium. The lens remained in close contact to the ectodermal layer, forming a thick lens stalk. At the 16-day stage, the corneal epithelium became irregular in thickness and the corneal stroma was discontinuous, having disarranged collagenous fibrils. In a few embryos the corneal endothelium was absent. In the squint-eyed embryo, the cornea bulged through the opened eyelids, while in an anophthalmic embryo it was thick and underdeveloped. Generally, the upper and lower eyelids of the exencephalic embryos were asymmetrical, and the lower lid appeared covered by a thick irregular peridermal layer.
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PMID:Malformations of the eye in the exencephalic tail-short mice during its development. 149 13

Horizontal, smooth pursuit eye movements were recorded from adults and children with infantile and late-onset esotropia using a remote, video-based, eye-movement recording system. Each subject monocularly tracked a 0.5-degree target moving back and forth on a video monitor at a constant velocity of 10 degrees, over a range of 12 degrees. Each subject's nasal and temporal gain (eye velocity/target velocity) was measured. Confirming the results of previous studies, we found that infantile esotropes had asymmetrical pursuit eye movements (nasal gain greater than temporal gain) while late-onset esotropes had symmetrical gains. However, unlike previous investigators, we found that half of the late-onset esotropes had impaired pursuit gain. The magnitude of the pursuit abnormality and the amount of refractive error were correlated--patients with the highest refractive error had the lowest pursuit gain.
J Pediatr Ophthalmol Strabismus
PMID:Pursuit eye movements in late-onset esotropia. 205 Dec 94

Behavioural methods were used to assess the visual development of two infants with a history of severe perinatal hypoxia. Both infants were born fullterm and showed hypoxic-ischaemic encephalopathy and subsequent cerebral palsy. Low visual acuity, small and asymmetrical visual fields, asymmetrical binocular and monocular OKN, and absent visual threat response were demonstrated initially. Ophthalmological examination revealed strabismus, but no further abnormalities. Longitudinal assessments up to the age of two years showed impressive (partial) improvements of visual functions. The mechanism for these improvements is unknown. The present study emphasizes the necessity of repeated testing of visual functions in infants with cerebral damage after perinatal hypoxia.
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PMID:Partial visual recovery in two fullterm infants after perinatal hypoxia. 235 88

To correct compensatory head turn in twelve cases with congenital nystagmus, they were classified into two types according to the relative visual lines of both eyes to each other with respect to the sagittal axis of the head or the median plane of the body. One was termed the symmetrical pattern and the other was termed the asymmetrical pattern. In cases of the symmetrical pattern, a neutral zone exists in which the dominant eye in in the adducted position of gaze with esotropia and in the abducted position of gaze with exotropia. However, in the case of the asymmetrical pattern the neutral zone of the dominant eye is located in the abducted position of gaze with esotropia and in the abducted position of gaze with exotropia. Surgery was performed by shifting the dominant eye to the direction of the sagittal axis of the head in accordance with the degree of ocular deviation in the primary position. In asymmetrical pattern cares, both eyes were surgically shifted in parallel to the direction of the sagittal axis of the head without regard to the types of strabismus. The operation was based on the degree of compensatory head turn. We compared the surgical results the two types. In symmetrical cases, decreasing strabismus was disappointing compared to the head turn, while in asymmetrical cases decreasing head turn was disappointing as compared to strabismus. From these results surgery should be confined to the dominant eye in symmetrical cases, taking as the basis for operation the degree of head turn and not the ocular deviation.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Surgical treatment of torticollis in cases of congenital nystagmus with strabismus]. 261 Jan 64

Sector occlusion, already described in 1953, has been used regularly since Berrondo's first publication on the subject in 1967 by a great number of ophthalmologists and orthoptists for convergent concomitant and sometimes divergent strabismus treatment. Sectors limit the field of fixation of each eye, in order to modify the optomotor reflex to restore and maintain the sensory and motor alternation. The mostly used sector designs are the symmetrical or asymmetrical binasal ones. The way of action of middle, narrow or broad, straight or oblique, or eventually "V" shaped binasal sectors can easily be analysed; their application does'nt present any particular difficulties; their reproduction is easy. Such is not the case of the so called "buridanization", location/observation and other numerous sophisticated shapes suggested by Berrondo. Sector-occlusion indications, advantages and disadvantages, limits and counter-indications are related in details. There is no doubt that binasal sectors represent a major acquisition for concomitant strabismus visual reeducation; they are irreplaceable in the treatment of congenital strabismus.
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PMID:[Critical study of sectorial occlusion in the treatment of strabismus in children]. 359 58


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