Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Outcome, prognosis and course of pigmentary glaucoma were studied in 38 patients (75 eyes). The mean age of the subjects at the time of diagnosis was 34.0 years and at the time of the study 44.1 years. The follow-up time ranged from 2 to 30 years with a mean follow-up time of 10.1 years. At the time of the study eighty-nine percent of the eyes had normal vision (0.7 or better), 3% slight impairment of vision (0.6-0.3), 5% low vision (0.2-0.05) and 3% were blind. Visual field defects were mild in 78%, moderate in 13% and severe in 8% of the eyes. One eye (1%) had normal fields. In 8 patients the stage of the field defects was asymmetrical between the two eyes. All were able to read at least monocularly with glasses. No one was blind, retired early or professionally limited because of pigmentary glaucoma. Thirty-nine eyes were on topical treatment. Fifteen eyes had additionally been treated with laser trabeculoplasty when the glaucoma could not be stabilized with topical treatment combined with systemic acetazolamide. Further twenty eyes had undergone trabeculectomy, 18 of them when medical treatment had failed and 2 following LTP. The non-involved eye of a patient suffering from a monocular disease was without treatment. The mean intraocular pressure at the time of the diagnosis was 33.5 mmHg (SD 10.4 mmHg) and at the final visit 17.5 mmHg (SD 3.4 mmHg). Four eyes were operated for cataracts and one for retinal detachment.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Long-term prognosis of pigmentary glaucoma. 175 Mar 11

Retinal detachment was observed as a cause of blindness in small numbers of reared pheasants in widely separated geographical areas. Lesions were bilateral but asymmetrical in 16 birds. In three pheasants only one eye was affected. Clinical signs were first noticed at 5 weeks of age. Affected birds were blind by the time they were mature. Early lesions comprised subretinal fluid and degeneration of the vitreous body. Following separation of the retina at the junction of the pigmented epithelium and photoreceptors, adhesions took place between the detached tissue and both the pecten and lens. Peripheral cystoid defects were seen concomitantly in the retinas of seven pheasants but these were bilateral in only two individuals. The cause of the disease is unknown.
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PMID:Retinal detachment in the pheasant (Phasianus colchicus). 1876 70