Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three cases of progressive facial hemiatrophy are presented. In all three cases there is evidence of localised scleroderma or morphea in association with the facial hemiatrophy. This would seem to support the contention that the two disorders are closely related. In two cases, ocular complications are prominent and in one Raynaud's phenomena provide clear asymmetrical dilatation of the lateral ventricle suggest that there may be a central rather than a peripheral cause for the sympathetic overactivity.
 ...
PMID:Progressive facial hemiatrophy (Parry-Romberg syndrome). 102 96

We report three cases of Raynaud's syndrome with digital ischaemic ulceration, in association with carpal tunnel syndrome. In all cases, the aetiology of the Raynaud's syndrome was probably unrelated to the nerve compression. However, symptoms were worse on the side of the median nerve lesion in two patients and worse on the side with the most severe nerve dysfunction in the third; symptoms were relieved by carpal tunnel decompression in two patients. We suggest that carpal tunnel syndrome may exacerbate Raynaud's syndrome and should be considered particularly in patients with asymmetrical digital lesions.
 ...
PMID:Raynaud's syndrome and carpal tunnel syndrome. 398 46

Transcutaneous video microscopy opens a way to measure capillary red blood cell speed, to analyzed transcapillary diffusion and pericapillary distribution of Na-fluorescein injected i.v. and to depict the superficial lymphatic capillaries by subepidermal microinjection of FITC-labelled dextran in human skin. The dynamic phenomena may be quantitiated by video densitometers provided the information is stored on video tape. Already, some physiological and clinical data have been obtained. The velocity pattern of erythrocytes in nailfold capillaries is continuous or intermittent with flow stops. Standardized cold provocation tests are useful to evaluate Raynaud's disease. In patients with scleroderma the transcapillary passage of Na-fluorescein is increased, the physiological pericapillary halo partially destroyed and the interstitial distribution of the dye asymmetrical. In primary lymphedema the lymphatic network filled from the deposit of fluorescent dextran extends much more than in healthy controls. Pathological lymphatic microvessels occur.
 ...
PMID:[New ways of studying the cutaneous microcirculation in clinical medicine (author's transl)]. 719 91

IgG4-related disease (IgG4-RD) is a recently established clinical entity characterized by high levels of circulating IgG4, and tissue infiltration of IgG4(+) plasma cells. IgG4-RD exhibits a distinctive fibroinflammatory change involving multiple organs, such as the pancreas and salivary and lacrimal glands. The skin lesions of IgG4-RD have been poorly characterized and may stem not only from direct infiltration of plasma cells but also from IgG4-mediated inflammation. Based on the documented cases together with ours, we categorized the skin lesions into seven subtypes: (1) cutaneous plasmacytosis (multiple papulonodules or indurations on the trunk and proximal part of the limbs), (2) pseudolymphoma and angiolymphoid hyperplasia with eosinophilia (plaques and papulonodules mainly on the periauricular, cheek and mandible regions), (3) Mikulicz disease (palpebral swelling, sicca syndrome and exophthalmos), (4) psoriasis-like eruption (strikingly mimicking psoriasis vulgaris), (5) unspecified maculopapular or erythematous eruptions, (6) hypergammaglobulinaemic purpura (bilateral asymmetrical palpable purpuric lesions on the lower extremities) and urticarial vasculitis (prolonged urticarial lesions occasionally with purpura) and (7) ischaemic digit (Raynaud phenomenon and digital gangrene). It is considered that subtypes 1-3 are induced by direct infiltration of IgG4(+) plasma cells, while the other types (4-7) are caused by secondary mechanisms. IgG4-related skin disease is defined as IgG4(+) plasma-cell-infiltrating skin lesions that form plaques, nodules or tumours (types 1-3), but may manifest secondary lesions caused by IgG4(+) plasma cells and/or IgG4 (types 4-7).
...
PMID:IgG4-related skin disease. 2540 91