Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The coincidence of arthritis with polymyalgia rheumatica (PMR) or temporal arteritis (TA) is not well established. After reviewing the literature we found that 22% of patients suffering from PMR/TA present with additional signs of inflammatory joint involvement. Joints predominantly affected are the sternal junctions, knee and shoulder joints, and the wrists, involvement of the latter frequently resulting in carpal tunnel syndrome. With the exception of sternal junctions, bony erosions are rarely seen. In most cases, synovitis is mild, pauciarticular, asymmetrical, transient and not destructive. Little evidence for inflammatory involvement of spine or sacroiliac joints was found, thus, back pain in these patients should be considered as caused by osteoporosis of the spinal column, mostly due to prolonged corticosteroid treatment.
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PMID:[Joint involvement in polymyalgia rheumatica/temporal arteritis]. 265 37

Human leukocyte proteins from more than 150 patients with rheumatoid arthritis, together with age- and sex-matched controls, were analyzed by use of the ISO-DALT technique in two-dimensional polyacrylamide gel electrophoresis. Patients with ankylosing spondylitis, polymyalgia rheumatica, psoriatic arthritis, calcium tendinitis, post-infectious arthritis, and asymmetrical seronegative arthritis were also included as positive controls. Synthesis of several proteins, referred to by number as members of the "Rheuma" set, is shown to increase in the leukocyte preparations from patients with classical rheumatoid arthritis. Several of these proteins are specific to monocytes or granulocytes; others are of unknown cellular origin, but appear to be unique to rheumatoid arthritis. The Rheuma proteins appear to be indicators of disease activity, because their increased synthesis can be correlated with sedimentation rate and other clinical indices of rheumatoid disease activity.
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PMID:Two-dimensional electrophoretic analysis of human leukocyte proteins from patients with rheumatoid arthritis. 707 65

A polymyalgia rheumatica-like syndrome is occasionally the first clinical expression of disseminated cancer. Patients admitted to the medical ward of a general hospital during a 10-year period were surveyed for the presence of polymyalgia rheumatica (PMR) in the context of cancer. Five patients were identified with a PMR-like syndrome characterized by prominent systemic symptoms and one or more features dissimilar from PMR, such as a) age of fewer than 50 years, b) only one typical site involved, c) asymmetrical involvement at typical sites, d) additional painful joints, and e) no improvement on 10 mg/d prednisone treatment. There were four men and one woman. The ages ranged from 37 to 84 years. The onset of PMR-like symptoms preceded the initial diagnosis of cancer or of recurrent cancer by 1 to 3 months. On x-ray of the shoulder and pelvic girdles, lytic lesions were observed in one patient. Bone scintigraphy showed pathologic uptake suggestive of metastatic spread, particularly in the symptomatic segments, in all patients. The primary sites of cancer in the five patients were lung (n = 1), kidney (n = 1), colon (n = 2) and unknown (n = 1). Although a search for malignancy may not be justified in patients presenting with typical PMR, the present survey suggests that in patients with atypical PMR-like syndromes, there is significant risk of cancer involving bones and joints. Isotopic bone scan is an appropriate screening test for such a possibility.
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PMID:A polymyalgia rheumatica-like syndrome as presentation of metastatic cancer. 1907 94

Paraneoplastic syndrome is defined as tumor-associated symptoms and signs not related to the physical effects of primary or metastatic tumors. The mechanisms of this syndrome include the production of bioactive soluble factors by tumor cells and autoimmune diseases elicited by the immune responses against tumors. Production of bioactive soluble factors causes endocrinologic symptoms. The paraneoplastic autoimmune process may affect the nervous system, cutaneous tissue, musculoskeletal system, hematopoietic cells or kidneys. Paraneoplastic rheumatic diseases show symptoms similar to inflammatory myopathy, polyarthritis, vasculitis, cryoglobulinemia and polymyalgia rheumatica. Rapid onset, unusual age, asymmetrical involvement of joints or refractoriness to standard immunosuppressive therapy suggests the presence of paraneoplastic autoimmune diseases. Autoimmune hematopoietic disorders include pure red cell aplasia, autoimmune hemolytic anemia and thrombocytopenia. Unexplained anemia or thrombocytopenia may indicate the presence of lymphoid neoplasms. Membranous nephropathy is a well-known glomerular disease associated with malignancy, and membranoproliferative glomerulonephritis, minimal change nephrotic syndrome, and antineutrophil cytoplasmic antibody(ANCA)-associated crescentic glomerulonephritis may be seen in cancer patients. Age and sex-appropriate cancer screening should be performed in patients with nephrotic syndrome due to membranous nephropathy.
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PMID:[Paraneoplastic autoimmune disorders]. 2056 97