Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study of the duration of a simple motor response to a passive displacement of a finger in 67 patients with lumbar osteochondrosis revealed 11 patients in whom parameters of this response were asymmetrical. Clinically these patients were characterized by a more severe course, frequent exacerbations, and an early development of the disease and hereditary predisposition to it. Sharp awkward movements were the most frequent provoking factor.
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PMID:[Status of deep muscle sensitivity and its role in the pathogenesis and course of lumbar osteochondrosis]. 382 65

Tibia vara (Blount's disease) is characterized by two components, the epiphyseal, which is concerned with articular relationships, and physeal/metaphyseal, which may produce angulation of a long bone. Although the initial etiology is not known, it appears that asymmetrical pressure applied to the angulated proximal tibia results in progressive deformity. In the initial stages, medial and posteromedial pressure causes growth retardation of the epiphysis (articular instability) and the physis (tibia vara). Nonsurgical or surgical treatment that relieves the pressure generally permits reconstitution of normal growth. Continued abnormal pressure and shear forces applied to the physis may result in disorderly enchondral ossification and produce a true osteochondrosis, which may lead to permanent physeal arrest. Osteotomy alone to relieve medial pressure may allow the tibia to grow straight, but residual medial epiphyseal compression and joint instability may persist. A case is reported of a 13 1/2 year follow-up of a patient in whom intraepiphyseal osteotomy restored articular congruity without interfering with longitudinal growth. The risks and experimental nature of this procedure are emphasized.
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PMID:Intraepiphyseal osteotomy for progressive tibia vara: case report and rationale of management. 707 38