Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The temporomandibular joint (TMJ) and dental occlusion were investigated clinically and radiographically in 59 patients aged 23-83 (mean, 58) years with general joint disease. Forty-nine had rheumatoid arthritis (RA), mostly of long duration. The patients were divided into four groups by type of dentition. Radiographic TMJ abnormality was found in about 4 of 5 patients with RA, in both the dentate and the edentulous group. The abnormality was mainly destructive with productive signs, but in the edentulous group erosive and asymmetrical changes occurred more often. Almost complete restriction of the condylar translation and severely restricted mouth opening (less than or equal to 30 mm) rarely occurred, although the translatory motion was restricted in several patients. Many of these had a satisfactory mouth opening (greater than 40 mm). Occlusal changes-various degrees of anterior bite opening-were reported by about one fourth of both the dentate patients and the complete denture wearers. One patient had occlusal contact on the second molars only. Anterior bite opening occurred only in patients with radiographic TMJ abnormality, including 5 of the 6 patients with complete mandibular head destruction.
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PMID:Temporomandibular joint involvement and dental occlusion in a group of adults with rheumatoid arthritis. 658 69

The forces distributed on six Nobelpharma implants were analyzed by strain gauges fixed to various implant combinations that were placed in a replica of a human edentulous mandible and connected to a cast gold alloy superstructure. The mandible was supported on its lower border and the superstructure loaded in different locations. Although force distribution was found to be asymmetrical, statistical analysis revealed no significant differences. Loads applied to one side of the superstructure were largely carried by the implants on that side, demonstrating torquing of the casting in the midline. Loads applied to the cantilever resulted in large extension forces in implants on the opposite side of the fulcrum. The magnitudes of the loads distributed on the screw varied as a result of the combinations, inter-implant spaces, and implant locations.
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PMID:Load distribution on implants with a cantilevered substructure: an in vitro pilot study. 915 16

Facial nerve paralysis is a daunting potential complication of parotid surgery and is widely reported. Knowledge of the key landmarks of the facial nerve trunk is essential for safe and effective surgical intervention in the region of the parotid gland. In current practice, wide ranges of landmarks are used to identify the facial nerve trunk, however, there is much debate in the literature about the safety and reliability of each of these landmarks. The aim of this study, therefore, was to evaluate the relation of the surrounding anatomical structures and surgical landmarks to the facial nerve trunk. The anatomical relationship of the facial nerve trunk to the surrounding structures was determined after micro-dissection on 40 adult cadavers. The shortest distances between the facial nerve and the "tragal pointer", attachment of the posterior belly of digastric muscle, tympanomastoid suture, external auditory canal, transverse process of the axis, angle of the mandible and the styloid process were measured. In addition, these distances were compared in the right and left sides, males and females and edentulous and non-edentulous mandibles. The distance of the facial nerve trunk from each of the surrounding landmarks ranged from (mm): tragal pointer, 24.3 to 49.2 (mean 34); posterior belly of digastric, 9.7 to 24.3 (mean 14.6); external auditory canal, 7.3 to 21.9 (mean 13.4); tympanomastoid suture, 4.9 to 18.6 (mean 10.0); styloid process, 4.3 to 18.6 (mean 9.8); transverse process of the axis, 9.7 to 36.8 (mean 16.9); angle of the mandible, 25.3 to 48.69 (mean 38.1). The length of the facial nerve trunk from its point of exit from the stylomastoid foramen to its bifurcation into upper and lower divisions ranged from (mm) 8.6 to 22.8 (mean 14.0). The results demonstrated that the posterior belly of digastric, tragal pointer and transverse process of the axis are consistent landmarks to the facial nerve trunk. However, it should be noted that the tragal pointer is cartilaginous, mobile, asymmetrical and has a blunt, irregular tip. This study advocates the use of the transverse process of the axis as it is easily palpated, does not require a complex dissection and ensures minimum risk of injury to the facial nerve trunk.
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PMID:Landmarks of the facial nerve: implications for parotidectomy. 1663 75

This article describes a form of localized aggressive periodontitis (LAP) in young multiparous women and denotes this form of periodontitis as localized aggressive multiparous periodontitis (LAMP). The authors retrospectively reviewed six cases of LAP in healthy multiparous women who were followed clinically for more than five years, examining clinical histories, clinical findings, and radiographic features. Age, race, gender, parity, location of attachment loss, rate of attachment loss, and symptoms were recorded. LAMP is characterized by asymmetrical attachment loss along the distal proximal area of the maxillary and/or mandibular first permanent molars in multiparous females with a median age of 27. The mean annual rate of attachment loss in the maxillary first molars was calculated at 0.5 mm. LAMP progresses to involve the mandibular incisors but, unlike LAP, appears to spare the maxillary incisors. The authors suggest that LAMP is a recognizable periodontal disease that can be diagnosed in young, multiparous females via clinical history, periodontal examination, and radiographs. This study presents potential pathogenic pathways and suggests a possible answer to the paradox of why aging women become more edentulous than men despite better overall dental care.
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PMID:Localized aggressive multiparous periodontitis: a newly documented entity. 2190 69

One of the main objectives of the forensic sciences is establishing a person's identity which can be a very complex process. The analysis of the teeth, fingerprints and DNA evaluation are probably the most used techniques allowing fast and secure identification processes. Palatal rugae or transverse palatine folds are asymmetrical and irregular elevations of the mucosa located in the anterior third of the palate and are permanent, prominent and unique for individuals and thus can be used as identification for forensic purposes widely in edentulous patients wherein no teeth are present in the oral cavity. In forensic odontology dentists play a prime role in supporting legal and criminal issues. Palatoscopy or palatal rugoscopy is the name given to the study of palatal rugae in order to ascertain a person's identity. Studies have demonstrated that no two individual rugae patterns are alike in their configuration and the characteristic rugae pattern of the palate does not change as a result of growth. Hence this article reviews the significance of palatal rugae patterns in edentulous cases as a reliable forensic marker.
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PMID:Palatal Rugae Patterns in Edentulous Cases, Are They A Reliable Forensic Marker? 2650 4