Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A questionnaire and an examination were given to 617 women to determine whether oral hormonal contraceptives might cause a chloasmalike hyperpigmentation and its frequency and whether clinically this type of hyperpigmentation could be delineated from those of other causes. 105 of the women were 17-41 years old in the 2nd to 10th month of pregnancy; the other 512 were 15-57 years old: 4 had chloasma, 322 had skin diseases, 154 accompanied children with skin diseases to the Dusseldorf University Dermatological Clinic, and 32 were clinic personnel. A surprising 45% were using or had used oral contraceptives. 94.5% regularly employed cosmetics. 60 women (11.7%) had chloasmal hyperpigmentation; the figure was 16.2% for the pregnant group (17 women). But 28 of the 60 chloasma patients had not used contraceptives. Thus, a cosmetic-induced berlock dermatitis was suspected. 4 patients clearly had chloasma gravidarum (melasma). In other cases, contact with estrogen and gestagen preparations as well as with the "pill" was established. The clinical appearance of the facial pigmentation signs could not always be correlated with the etiology. Several patients had a sudden recrudescence of hyperpigmentation when exposed to strong sunlight, whether thay had been using cosmetics or contraceptives. This was particularly noted in the summertime. This clinical experience shows that oral contraceptives can induce chloasmalike facial hyperpigmantation; its frequency can be easily overestimated unless cosmetic-induced chloasma is excluded. To an extent, an etiological diagnosis can only be made if asymmetrical berlock dermatitis is present. The "pill-induced chloasma" is light-dependent to a great extent, so women using contraceptives should avoid unnecessary exposure to the light and should use strong protective agents. The likelihood of complications is greater in women who by constitution have heavily pigmented nipples and eyes.
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PMID:[Clinical aspects of pigmentation disorders due to oral contraceptives]. 464 60