Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Enkephalinergic axons and terminals were identified by the PAP immunohistochemical method in lamina I (marginal zone) and lamina IIO (outer substantia gelatinosa) in the dorsal horn of the monkey spinal cord. Synaptic profiles with enkephalin-like immunoreactivity (MELI) contained clear, round, vesicles, sometimes a few large granular vesicles, and usually formed asymmetrical contacts. MELI terminals forming synaptic contacts with various sizes of dendrites and with dendritic spines were the most common type of relationship found; axosomatic contacts were few. Additionally, two types of complexes were observed in which an MELI terminal formed a specialized apposition with an unlabelled terminal. The contact often resembled a synapse and in most cases the MELI terminal was suspected to be presynaptic. One complex consisted of a MELI terminal apposing the LGV type terminal (containing large granular vesicles), which in turn was presynaptic to a dendrite. (The identity of the LGV terminal could not be determined, but it had some characteristics similar to those described for substance P terminals and for a class of primary afferents in the monkey dorsal horn). The other type of complex consisted of a MELI terminal apposing an R-type terminal (containing small, round, clear vesicles) which was in turn presynaptic to a dendrite. Often, the MELI terminal also formed a synapse onto the same dendrite. The axodendritic, axospinous and axosomatic contacts of MELI terminals in the superficial dorsal horn may produce some of the depressive postsynaptic-like effects of enkephalin iontophoresis onto dorsal horn neurons. In these cases the responses of dorsal horn neurons to both low threshold and nociceptive primary afferents is suppressed. However, the opiate receptor-dependent PAD of C-fibers observed in the dorsal horn may be mediated by the MELI complexes formed with LGV and R terminals found in lamina I.
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PMID:Ultrastructure of chemically defined neuron systems in the dorsal horn of the monkey. II. Methionine-enkephalin immunoreactivity. 635 63

A 44-year-old man who has sex with men presented with a three-month asymmetrical polyarthropathy. He had a positive HIV-1 antibody test consistent with infection acquired more than six months previously. Lymphogranuloma venereum (LGV)-associated DNA was detected from a rectal swab. Following successful treatment for LGV his arthritis resolved completely. Infection with HIV-1 has been hypothesized to cause reactive arthritis but this has been disputed. The most likely diagnosis in this patient was sexually acquired reactive arthritis secondary to LGV infection. As LGV can be asymptomatic and treatment differs from that of the other serovars, screening should be considered in all men who have sex with men (MSM) presenting with acute arthritis, particularly if they are HIV infected.
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PMID:Acute seronegative polyarthritis associated with lymphogranuloma venereum infection in a patient with prevalent HIV infection. 2136 72