Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An acute pulmonary syndrome possibly representing acute graft-versus-host disease (GVHD) involving lung interstitium occurred in a patient given an allogeneic bone marrow transplant for haematological malignancy. He presented at day 34 with acute GVHD of skin and bowel, and this was associated with cough, dyspnoea and an asymmetrical change on chest X-ray. Lung biopsy demonstrated an interstitial and peribronchial lymphocytic infiltrate and acute bronchial epithelial degeneration. He responded symptomatically to high dose intravenous methylprednisolone. The radiological change resolved completely. This case, thought to represent GVHD involving lung interstitium, emphasizes the need for tissue procurement in the management of non-bacterial lung disease after marrow transplantation.
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PMID:An acute pulmonary syndrome possibly representing acute graft-versus-host disease involving the lung interstitium. 195 5

Differential lung ventilation (DLV) with PEEP has been used to oxygenate patients with severe unilateral or asymmetrical lung disease. Many different ventilator systems have been used to deliver DLV, but the question of whether or not to synchronize the ventilation of the 2 lungs has not been answered. Twelve mongrel dogs were given a unilateral hydrochloric acid (HCl) injury and divided into 2 groups, one receiving synchronous and the other receiving asynchronous DLV. The assignment of synchronization and side of injury was allocated randomly. A computer-controlled DLV system was used to ventilate the dogs with equal tidal volumes to each lung. The respiratory rate was feedback controlled to maintain PaCO2 at 35 torr. After injury, 10 cm H2O of PEEP was applied to the injured lung and the dogs were ventilated with FIO2 = 0.40 for 4 h. There was no statistically significant difference in gas exchange ([PaO2, Qva/Qt, PaCO2, P(A-a)O2] or hemodynamics [mean arterial pressure (MAP), CVP, mean pulmonary arterial pressure (MPAP), mean pulmonary arterial wedge pressure (WP), cardiac output in triplicate (Q), heart rate (HR)] between the 2 groups. With this particular model, there is no need to synchronize the 2 ventilators when using DLV with unilateral PEEP.
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PMID:Synchronous versus asynchronous differential lung ventilation with PEEP after unilateral acid aspiration in the dog. 634 44

Differential lung ventilation with positive end expiratory pressure (PEEP) improves pulmonary gas exchange when used in the supportive care of patients with severe unilateral or asymmetrical lung disease. Once the provision of selective PEEP to the two lungs is accomplished, the best method of partitioning the tidal volume between the two lungs is unknown. Twelve mongrel dogs were given a unilateral hydrochloric acid (HCl) aspiration injury. A computer controlled differential lung ventilation system was used to ventilate four dogs with equal volumes to each lung, four dogs with equal driving pressure (end inspiratory pressure-PEEP) to each lung, and four dogs with equal end-tidal CO2 fraction from each lung. The respiratory rate was feedback controlled to maintain PaCO2 at 4.67 kPa. The dogs were kept supine and ventilated with 30% O2. Following injury, the PEEP was set at 0 kPa for 1 h. The dogs were then given 1.36 kPa and 2.72 kPa PEEP to the injured lung for 2 h in a cross-over fashion. The assignment of the tidal volume controller, the side of injury, and the PEEP sequence was random. Oxygen tension fell and pulmonary venous admixture increased after giving the HCl injury. In all three groups considered simultaneously, unilateral PEEP improved PaO2 and venous admixture. The equal tidal volume distribution was the only group to show a significant improvement in PaO2 at both PEEP increments (0 to 1.36 kPa and 2.72 kPa). There was a significant difference in tidal volume allocation between the three groups with the equal end-tidal and equal pause pressure groups only minimally ventilating the injured lung.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Differential lung ventilation with unilateral PEEP following unilateral hydrochloric acid aspiration in the dog. 635 57

Differential lung ventilation (DLV) may be necessary in the supportive care of patients with severe unilateral or asymmetrical lung disease. The best method for allocating tidal volume between the 2 lungs is unknown. Eighteen mongrel dogs were given a unilateral hydrochloric acid (HCI) aspiration injury. A computer-controlled differential lung ventilation system was used to ventilate 6 dogs with equal volumes in each lung, 6 dogs with equal end-inspiratory pressure in each lung, and 6 dogs with equal end-tidal CO2 fraction in each lung. The computer allocated volume between the 2 lungs by these 3 schemes on a breath-by-breath basis and maintained PaCO2 at 35 torr and total tidal volume at 15 ml/kg. Oxygen tension fell and pulmonary venous admixture increased after aspiration. There were no differences in gas exchange among the groups. Without PEEP, differential partitioning of tidal volume is of little consequence in differential lung ventilation of asymmetrical injuries.
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PMID:Differential lung ventilation after unilateral hydrochloric acid aspiration in the dog. 657 21

Intrauterine growth restriction (IUGR) is characterized by fetal growth less than normal for the population and growth potential of a given infant. IUGR can be symmetrical with low weight, length and head circumference indicative usually of a process with its origin early in pregnancy or asymmetrical with sparing of head circumference and length due to processes occurring later in gestation. The acute neonatal consequences of IUGR are perinatal asphyxia and neonatal adaptive problems. These adaptive problems that include respiratory distress due to meconium aspiration, persistent pulmonary hypertension or pulmonary hemorrhage, abnormalities of glucose regulation, temperature instability, and polycythemia are reviewed in this article. Issues specific to the IUGR preterm infant are reviewed as well including an increased incidence of chronic lung disease, necrotizing enterocolitis, retinopathy of prematurity and postnatal growth failure.
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PMID:The IUGR newborn. 1848 25

Proteus syndrome is a rare, sporadically occurring hamartomatous disorder with complex multisystem involvement and wide clinical variability. Clinical characteristics include craniofacial abnormalities; asymmetrical overgrowth of the trunk, limbs, and digits; lipomas; and vascular malformations. Cystic lung disease is noted in approximately 10 per cent of patients. These cystic malformations may lead to cystic pulmonary emphysema, which may cause significant morbidity for the patient. We describe the case of a 27-year-old woman with known Proteus syndrome who developed acute on chronic respiratory failure. Subsequent CT scan of the chest was significant for extensive bullous disease with nearly complete replacement of the right lung tissue. Our operative management and the patient's clinical course are described.
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PMID:Proteus syndrome: a case report. 1977 61