Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Horizontal, smooth pursuit eye movements were recorded from adults and children with infantile and late-onset esotropia using a remote, video-based, eye-movement recording system. Each subject monocularly tracked a 0.5-degree target moving back and forth on a video monitor at a constant velocity of 10 degrees, over a range of 12 degrees. Each subject's nasal and temporal gain (eye velocity/target velocity) was measured. Confirming the results of previous studies, we found that infantile esotropes had asymmetrical pursuit eye movements (nasal gain greater than temporal gain) while late-onset esotropes had symmetrical gains. However, unlike previous investigators, we found that half of the late-onset esotropes had impaired pursuit gain. The magnitude of the pursuit abnormality and the amount of refractive error were correlated--patients with the highest refractive error had the lowest pursuit gain.
 ...
PMID:Pursuit eye movements in late-onset esotropia. 205 Dec 94

To correct compensatory head turn in twelve cases with congenital nystagmus, they were classified into two types according to the relative visual lines of both eyes to each other with respect to the sagittal axis of the head or the median plane of the body. One was termed the symmetrical pattern and the other was termed the asymmetrical pattern. In cases of the symmetrical pattern, a neutral zone exists in which the dominant eye in in the adducted position of gaze with esotropia and in the abducted position of gaze with exotropia. However, in the case of the asymmetrical pattern the neutral zone of the dominant eye is located in the abducted position of gaze with esotropia and in the abducted position of gaze with exotropia. Surgery was performed by shifting the dominant eye to the direction of the sagittal axis of the head in accordance with the degree of ocular deviation in the primary position. In asymmetrical pattern cares, both eyes were surgically shifted in parallel to the direction of the sagittal axis of the head without regard to the types of strabismus. The operation was based on the degree of compensatory head turn. We compared the surgical results the two types. In symmetrical cases, decreasing strabismus was disappointing compared to the head turn, while in asymmetrical cases decreasing head turn was disappointing as compared to strabismus. From these results surgery should be confined to the dominant eye in symmetrical cases, taking as the basis for operation the degree of head turn and not the ocular deviation.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Surgical treatment of torticollis in cases of congenital nystagmus with strabismus]. 261 Jan 64

Our surgical treatment of the A and V phenomena consists of a systematic combination of oblique and horizontal muscle surgery. The oblique muscles are desagittalized: the plane of action of the muscle is displaced forwards so that its angle with the visual axis enlarges. The vertical action of the oblique muscle is thus reduced in favour of the torsional action. This desagittalization is always performed bilaterally and combined with a bilateral recession of a rectus muscle: the medial rectus muscles in cases of esotropia and the lateral rectus muscles in cases of exotropia. A real vertical deviation (RVD), if present, is treated by asymmetrical oblique muscle surgery or by the weakening of a vertical rectus muscle. In cases of under- or overcorrection a remaining diagonal and vertical deviation is carefully searched for and dealt with. In addition, a horizontal undercorrection is treated by placing a secondary loop on the already recessed medial rectus muscle, and a horizontal overcorrection is treated by weakening both lateral rectus muscles.
 ...
PMID:Surgical treatment of the A and V phenomena. 696 55

Numerous observations in children under two years of age tend to demonstrate that the functional amblyopia of esotropia is not congenital in origin, but develops progressively between the ages of 3 months and 2 years. The initial motor disorder is an abduction deficiency. When this is symmetrical there is no amblyopia, but there is a greater risk for the deviated eye to become amblyopic when the deficiency is, or becomes, asymmetrical. Preventive treatment of the amblyopia involves the wearing of symmetrical nasal sectors, with associated partial occlusion in established cases, duration of which depends upon the child's age. Marked amblyopia with nasal fixation requires the use of a nasal sector placed in front of the amblyopic eye (associated with occlusion of the normal eye).
 ...
PMID:[Prevention and treatment of amblyopia in children under two years of age (author's transl)]. 710 31

We investigated the clinical factors affecting the development of consecutive exotropia following esotropia surgery. The development period of consecutive exotropia, amblyopia and limitation of adduction were evaluated in 89 patients with primary esotropia that changed to consecutive exotropia after surgery. In the presence of deep amblyopia, consecutive exotropia developed earlier. When two horizontal muscles were operated, limitation of adduction was more frequent in symmetrical rather than asymmetrical surgical procedure. Since consecutive exotropia may develop many years after esotropia surgery, a long-term follow-up period in patients without consecutive exotropia in the early postoperative period is advised.
 ...
PMID:Consecutive exotropia following strabismus surgery. 1220 26

Dissociated vertical deviation (DVD), a vertical strabismus, is often associated with infantile esotropia, latent nystagmus and excyclo-torsion. DVD usually becomes apparent at about three years of age. The authors wished to determine whether DVD is a manifestation of an abnormal motor vergence system or is part of a visual system disorder. Vertical eye movements of six subjects with DVD, on cover-uncover and alternate cover tests, were studied using the magnetic search eye coil system. Asymmetry between the eyes' saccades were quantified during the DVD upward movement and during a trial of pure vertical saccades. In three subjects the vertical deviation increased to its full amount through a smooth vertical divergence movement, and in the other three patients through a combination of smooth and asymmetrical saccade-like movements. The latencies of the DVD, the peak velocity of the deviation movements, its time constant and the asymmetries in the saccades suggest that DVD represents an abnormal vertical vergence system.
 ...
PMID:Dissociated vertical deviation (DVD): The saccadic and slow eye movements. 2131 45

Dissociated vertical deviation (DVD) is a slow, disconjugate hypertropic deviation of a nonfixating eye. It is usually bilateral, asymmetrical, and often associated with congenital esotropia. The deviating eye elevates, abducts, and excyclotorts. This type of strabismus is often variable, making measurement and clinical quantification difficult. Specific knowledge of the mechanisms and characteristics of the dissociated deviation are required for proper assessment and effective treatment. There is currently no consensus on the mechanisms and pathophysiology of DVD. In this workshop, participants discuss the characteristics and most current methods for assessing and quantifying the deviation and explore the potential etiologies, clinical characteristics, and indications for surgical intervention and nonsurgical management of DVD.
 ...
PMID:DVD--a conceptual, clinical, and surgical overview. 2517 3

CLOVES syndrome characterized by Congenital Lipomatous Overgrowth, Vascular malformations, Epidermal nevi, and Skeletal anomalies is a recently described sporadic syndrome from postzygotic activating mutations in PIK3CA. This 3-year-old boy, born to nonconsanguineous and healthy parents, had epidermal verrucous nevus, lower limb length discrepancy and bilateral genuvalgum, anterior abdominal wall lipomatous mass, central beaking of L2 and L3, and fibrous dysplasia of the left frontal bone. Ocular and dental abnormalities (ptosis, esotropia, delayed canine eruption, dental hypoplasia), ipsilateral asymmetrical deformity of skull, and large left cerebral hemisphere with mild ipsilateral ventriculomegaly were peculiar to him denoting an uncommon phenotype. The parents did not consent for magnetic resonance imaging and genetic studies because of financial constraints. The CLOVES syndrome has emerged as an uncommon yet distinct clinical entity with some phenotypic variations. Its diagnosis is usually from cutaneous, truncal, spinal, and foot anomalies in clinical and radioimaging studies. Proteus syndrome remains the major differential.
 ...
PMID:Cloves Syndrome: A Rare Disorder of Overgrowth with Unusual Features - An Uncommon Phenotype? 3133 68