Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Next to tonic-clonic seizures psychomotor (complex focal) seizures are the most common form of all epileptic seizures, except in infancy where they are seen rarely. Differently from generalised non convulsive seizures (like petit mal absences), their first appearance has no typical age limit, however, their proportion to other forms of seizures increases in adolescence and adults especially between the third and fifth decade of life. The main symptom is the disorder of consciousness which lasts at least more than half a minute, normally several minutes in completely distinct seizures, which doesn't begin abruptly and which often ends ill defined. This twilight attack is proceeded by an aura of sensory, psychic or vegetative character. The aura is followed either by a transitory state of immobility and later by motor phenomena or at once by motor phenomena in the form of diverse automatisms of variable intensity, reaching from mild movements in the oral region over verbal expressions to highly dramatic scenes, often accompanied by vegetative symptoms. Tonic versive and tonic symmetrical or tonic asymmetrical seizure symptoms are quite often motor variants which also can lead to sudden drops. Psychomotor attacks can be reduced to "pseudo-absences", however, they also can develop into tonic-clonic seizures (Grand mal). Generally, the succession of seizure symptoms is constant in the same patient, the expression can differ from seizure to seizure. Psychomotor attacks can be spread over the whole day or can show a strict connection to sleep, in the course they can likely occur in clusters and can accumulate to a continuous or discontinuous form of psychomotor status epilepticus. Predominantly, but not exclusively psychomotor attacks start from the temporal lobe, whereas neocortical temporal attacks (especially of lateral posterior origin) can be distinguished from those coming from the limbic system, especially from hippocampal or mesio-basal temporal structures and from the nucleus amygdalae. About 20% of the psychomotor attacks are of frontal origin coming from the mesial frontal region or from the gyrus cinguli anterior. Also seizures of occipital or parietal origin can spread so quickly that the seizure itself is impressing as a "temporal lobe attack". On account of that, epilepsies with psychomotor attacks cannot be compared to temporal lobe epilepsies. The etiology of psychomotor epilepsies is closely connected to the topographic site of the temporal lobe, who is especially vulnerable for traumatic lesions, cerebral edema and hypoxemia. Also small dysgeneses, heterotopies or small abnormalities of vessels are relatively often found in surgical specimens.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[Psychomotor epilepsy: phenomenology, localization, pathogenesis and therapy]. 219 20

The study included 203 epileptic absences: 1. Simple; (30 cases); 2. Myoclonic petit mal absences (62 cases); 3. Amyotonic-akinetic absences (41 cases); 4. Temporal lobe absences (62 cases); 5. "Hybrid" absences in Lennox-Gastaud disease (13 children). This paper presents only the myoclonic petit mal absences (57 cases). Correlations of the clinical, EEG and polysomnographic data were found by several methods: a. The patients were video-monitored on an infrared closed-circuit TV screen: b. The Hjorth's NSD parameters were computed on a Siemens-Elema Mingograph; c. The EEG graphoelements were morphologically analyzed every second throughout the discharges, by means of an original technique; d. Computerized EEG mappings (CEM) were performed for various periods, also including the sequential ones, second by second, all along the epileptic discharges; e. 8 hours of continuous polysomnographic recordings. The peculiar electroclinical features of the five types of absences have been emphasized. Regarding the myoclonic petit mal absences, the discharges of polyspikes and waves manifested an evident increase in the number and duration within the LSWS stages and during the transition from the wakefulness state to sleep and from the LSWS to the wakefulness, and a transformation in slow polyspikes and waves complexes during the stages III and IV. The CEM were always asymmetrical during sleep and the maximal amplitudes were seen on the anterior and posterior temporal regions. In all the REM stages, the polyspikes and waves disappeared.
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PMID:Polysomnographic and computerized electroencephalographic studies in myoclonic petit mal epilepsies. 836 77