Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The use of M-mode-echocardiography in infancy and childhood is presented in terms of its value in 2 problem areas. The first concerns the differential diagnosis of the innocent systolic heart murmur: mitral valve prolapse syndrome, atrial septal defect and asymmetrical septal hypertrophy have to be excluded. In the critically ill newborn and infant--the 2.problem area--5 diagnoses play the main role: The hypoplastic left and right heart syndrome, transposition of the great arteries, Fallot-truncus complex and endocardial fibroelastosis. Possibilities and limitations of single beam echocardiography are discussed.
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PMID:[The value of M-mode echocardiography in children]. 719 Sep 55

Severe asymmetrical hypertrophic cardiomyopathy without heart block accompanied by neuromuscular hypotonia and feeding difficulties was evident shortly after birth in the second child of a mother with systemic lupus erythematosus who had no indication of gestational diabetes. High-level anti-ribonucleoprotein (RNP) and Smoth (Sm) antibodies arising from transplacental transfer of maternal antibodies were detected in the child's serum. The cardiac abnormalities improved with a commensurate decline in antibody titers. Previously reported cases of neonatal cardiomyopathy with endocardial fibroelastosis have been ascribed to the transplacental transfer of maternal Sjogrens Syndrome (SS) A (Ro) and Sjogrens Syndrome (SS) B (La) antibodies and have been more severe and persistent compared with our patient. We advocate close monitoring of all babies of mothers with systemic autoimmunity for changes in heart rate during pregnancy and signs of heart failure and neuromuscular weakness after delivery.
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PMID:Resolution of neonatal hypertrophic cardiomyopathy presumed secondary to acquired maternal ribonucleoprotein and smith autoantibodies. 2414 43