Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Exencephalic tail-short (Ts/+) embryos were obtained from mating normal mice of Patch strain with Ts/+ mice from Babl/c strain. The most common eye malformations in the exencephalic embryos were exophthalmy, microphthalmy, eye ball irregularity and corneal opacity. Squint eye and unilateral anophthalmy occurred at a lower frequency. The eye abnormalities were recognized histologically by 11-days of gestation. The retina was retarded in development. Lens fibres were swollen and some of them appeared degenerated. Lens epithelium was protruded anteriorly, detached from the underlying lens and joined the corneal endothelium. The lens remained in close contact to the ectodermal layer, forming a thick lens stalk. At the 16-day stage, the corneal epithelium became irregular in thickness and the corneal stroma was discontinuous, having disarranged collagenous fibrils. In a few embryos the corneal endothelium was absent. In the squint-eyed embryo, the cornea bulged through the opened eyelids, while in an anophthalmic embryo it was thick and underdeveloped. Generally, the upper and lower eyelids of the exencephalic embryos were asymmetrical, and the lower lid appeared covered by a thick irregular peridermal layer.
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PMID:Malformations of the eye in the exencephalic tail-short mice during its development. 149 13

Corneal degenerations are among the most commonly encountered disorders in optometry. They are age-related, asymmetrical deteriorations of the cornea with no developmental or hereditary pattern. Although some corneal degenerations may cause pain and profound loss of vision, most are asymptomatic and visually insignificant. This paper will review the histological development, clinical presentation, and management of various peripheral corneal degenerations.
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PMID:Peripheral corneal degenerations. 181 21

We report 4 cases of gelatin drop dystrophy corneal amyloidosis in two brothers and two sisters of the same family. The age of onset is between 1 and 10 years. The corneal signs are described at different stages of development. Lesions are initially asymmetrical. The typical is a subepithelial nodule starting in the center and then expanding to involve the whole cornea. There is no relationship between extension and outcome of the disease. Diagnostic is confirmed by histological examination. There was no consanguinity between parents and no other cases were found in the family. An immunological study with HLA typing was performed. All patients were treated with lamellar or transfixing keratoplasty with a follow-up of 2 to 5 years.
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PMID:[Familial form of gelatin drop corneal dystrophy]. 188 Mar 40

The tremendous development of the photokeratoscope and corneal topography analysis explains the development of corneal astigmatism study in corneal graft. Our study consists in a review of the bibliography. The prevention of the astigmatism needs the following: before the trephination, the astigmatism has to be treated (correction of against the rule astigmatism which is usual in the aphake people); during the trephination, to minimize the deformation of the eye ball, to choose a good diameter for the keratoconus case, to use a pneumatic trephine in order to have a perpendicular cut (the use of the laser Excimer seams promising); The suture of the corneal graft can be done with a double running suture 10/0 and 11/0. The 10/0 is removed at the third month, the visual recovery is faster but the average astigmatism is not as good as with the interrupted 10/0 sutures and running suture 11/0. This technique is good for an old patient or a one eyed people specially interested in a faster recovery of visual acuity. The second possibility is to use 16 interrupted sutures with and 11/0 running suture. With this technique, the sutures are removed selectively depending on the keratometry and the photokeratoscopy. The visual recovery is longer but the astigmatism at the end is very low. When all the sutures have been removed, the residual astigmatism can be treated when there is not any misalignement between the cornea and the graft. The keratometry, photokeratoscopy allows to find the meridian which is abnormal and to find out if the astigmatism is symmetrical or asymmetrical. The astigmatism is symmetrical if the deformation is the same at either side of the meridian. When the abnormal meridian is the steepest, the only thing to do is a relaxing incision (one or two if is asymmetric, two if the astigmatism is symmetric). The size of the relaxing incision is determined by the photokeratoscopy and the deepness by the effect obtained during surgery looking at a qualitative keratometer. On the table, the effect must be about 50% of over correction. When, the abnormal meridian is the flattest, the only thing to do is a wedge resection (if the astigmatism is asymmetric) or two wedge resections (if the astigmatism is symmetric). The size of the cuneiform resection is choosen with photokeratoscopy. The study of the literature about the Ruiz incision adapted to corneal graft cannot nowadays conclude to the accuracy and safety of this technique.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[Astigmatism in corneal graft. Prevention and treatment]. 205 Sep 62

To understand how human corneal endothelium compensates for cell loss, nuclear DNA-cytofluorometry and cell morphometry were carried out on injured corneal endothelium. The examined corneas included two cases of keratoconus complicated with acute hydrops and one without acute hydrops, two cases of herpetic keratitis, one case of post-intracapsular cataract extraction (post-ICCE) and one case of luetic keratitis. The endothelial cell layer was separated from Descemet's membrane and double-stained with Rhodamine-labeled wheat germ agglutinin-lectin (WGA) and 4',6-diamidino-2-phenylindole dihydrochloride (DAPI). The area of each cell was measured with a color image analyser and compared with its cytofluorometric nuclear DNA content. The endothelium in apparently intact regions of the diseased corneas showed the same DNA-ploidy pattern and cell area as the physiological corneas. However, endothelial cells in injured regions had greater area, even in diploidy, than in presumably normal ones and showed a larger number of hyperploid cells ranging from 4C to 36C. Hyperploid cells consisted of many multinucleates and few polyploidies and had extremely large and bizarre cytoplasm. All injured corneas were accompanied by cells with numerous micronuclei. A few asymmetrical 4C-binucleates (with DNA values such as 1.3 plus 2.6C) appeared in the case of the post-ICCE. It is concluded that damage to human corneal endothelial cells in vivo results in cell enlargement with or without DNA synthesis. Those changes appear more severe in diseased corneas than in the situation of physiological aging which we have reported previously. In severe cases, micronuclei, polyploid cells and multinucleated giant cells are frequent, thereby suggesting a possible long-persistent metabolic impairment of the endothelium after severe damage to the cornea.
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PMID:Changes in nuclear DNA content and cell size of injured human corneal endothelium. 340 92

Cataract surgery is known to induce refractive and corneal astigmatism, but little is known regarding the specific corneal topographic alterations produced by this surgery. We evaluated the corneal topographic effects of extracapsular cataract extraction (ECCE) performed with an 8- to 11-mm posterior limbal incision closed with interrupted sutures and subsequent selective suture removal. Corneal topography was analyzed in 15 eyes with the TMS-1 videokeratoscope preoperatively, before selective suture removal 4-6 weeks after surgery, 2-5 weeks after selective removal of sutures, and at 5 1/2-8 months after surgery. The Surface Regularity Index was significantly increased before suture removal and after suture removal but returned to normal at the final examination. The Irregular Astigmatism Index remained significantly increased at all examinations after surgery. Corneal asymmetry (Surface Asymmetry Index) continued to be significantly increased compared with the preoperative examination after suture removal and at 6 months after surgery. The standard deviation of powers (SDP) was significantly elevated before and immediately after suture removal, but was not significantly different at 6 months. Mean corneal astigmatism remained significantly increased (0.80 +/- 0.11 preoperatively, 1.39 +/- 0.24 at maximum follow-up, p = 0.04). Significant changes in corneal topography occurred in each patient between suture removal and final examinations. A few patients developed against-the-rule astigmatism ranging from 0.6 to 2.2 diopters. ECCE significantly altered corneal tomography compared with the preoperative contour in all patients. In those patients in whom surgically induced nonspherical and noncylindrical distortions occur (radially asymmetrical power distribution, lack of central corneal smoothness), corneal topography may provide information that is useful for management.
Cornea 1996 Mar
PMID:Prospective study of corneal topographic changes produced by extracapsular cataract surgery. 892 69

Pitx2, a bicoid-related homeobox gene, is involved in Rieger's syndrome and the left-right (L-R) asymmetrical pattern formation in body plan. In order to define the genomic structure and roles of Pitx2, we analyzed the genomic structure and generated Pitx2-deficient mice with the lacZ gene in the homeobox-containing exon of Pitx2. We were able to show that among three isoforms of Pitx2, Pitx2c shows asymmetrical expression whereas Pitx2a, Pitx2b and Pitx2c show symmetrical expression. In Pitx2(-)(/)(-) embryos there was an increase in mesodermal cells in the distal end of the left lateral body wall and an amnion continuous with the lateral body wall thickened in its mesodermal layer. These changes resulted in a failure of ventral body wall closure. In lung and heart in which Pitx2 is expressed asymmetrically, right pulmonary isomerism, atrioventricular canals with prominent swelling, and juxtaposition of the atrium were detected. The hearts failed to develop tricuspid and mitral valves and a common atrioventricular valve forms. Further, dysgenesis of the Pitx2(-)(/)(-) extraocular muscle and thickening of the mesothelial layer of cornea were observed in the ocular system where Pitx2 is expressed symmetrically, and these resulted in enophthalmos. The present study shows that Pitx2 expressed in various sites participates in morphogenesis through three types of actions: the involvement of asymmetric Pitx2 expression in the entire morphogenetic process of L-R asymmetric organs; the involvement of asymmetric Pitx2 expression in the regional morphogenesis of asymmetric organs; and finally the involvement of symmetric Pitx2 expression in the regional morphogenesis of symmetric organs.
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PMID:Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism. 1057 50

Topographic disorders in the cornea, regression of the refraction effect, and subepithelial corneal opacities are characteristic complications of photorefraction keratectomy. Disorders in corneal topography are early haze, asymmetrical haze, and optic zone decentration. Disorders in topography lead to decrease in visual acuity, numerous optic effects (monocular doubling, aureola, blurred image, etc.). Methods for these complications control by means of transepithelial ablation, which is carried out with due consideration for the data of topographic examinations under pseudofluorescence control, normalizes corneal topography in the majority of cases, notably increases visual acuity, decreases doubling, etc. No side effects were observed after transepithelial phototherapeutic keratectomy for a period of up to 12 months.
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PMID:[Changes in corneal topography after photorefractive keratectomy in myopia and their elimination]. 1103 65

Wilson disease (WD) that manifests solely with acute and severe neurological damage in the absence of hepatic disease and Kayser-Fleischer ring of the cornea is rare and difficult to diagnose at the acute setting. This report describes unusual diffusion and proton spectroscopic magnetic resonance (MR) imaging findings in a 12-year-old boy with WD who presented with hemichorea and subnormal copper metabolism. The MR imaging findings of lactate accumulation, decrease of N-acerylaspartate/creatinine (NAA/Cr) ratio and markedly increased apparent diffusion coefficient (ADC) value of the asymmetrical edematous putaminal lesions in the early stage were suggestive of acute necrosis with anaerobic metabolism of glucose leading to poor clinical outcome at follow-up.
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PMID:Acute putaminal necrosis and white matter demyelination in a child with subnormal copper metabolism in Wilson disease: MR imaging and spectroscopic findings. 1590 72

Keratoconus is a noninflammatory, progressive disease with ectasia and thinning of the corneal stroma, leading to decrease visual acuity related to asymmetrical irregular astigmatism and myopia. Currently, patients with keratoconus who are contact lens intolerant, are primarily treated by penetrating keratoplasty. When the cornea is transparent, other options may be considered. There are several studies about intrastromal rings implantation, in eyes with keratoconus. The major objective of corneal ring implantation is to reshape the abnormal cornea without removing corneal tissue or touching the central cornea.
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PMID:[Present views concerning surgery treatment of keratoconus]. 1641 14


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