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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Forebrain-bisected cats underwent kindling at primary and secondary amygdala sites. The behavioral effect of amygdala kindling was then examined according to the extent of the surgical lesion in the forebrain commissures. Bisection of the corpus callosum with or without lesion of the hippocampal commissure modified both kindling and kindled symmetrical generalized seizure into a lateralized and asymmetrical form. Lesion of the hippocampal commissure was correlated with the loss of the expected positive transfer effect at the secondary amygdala site. These results suggest that whereas the corpus callosum plays a major role in patterning convulsive generalization and generalized convulsion, the hippocampal commissure is involved in mediation of the transhemispheric positive transfer effect. Evidence of a callosal inhibitory influence on amygdala kindling was not obtained.
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PMID:Role of the corpus callosum and hippocampal commissure on transfer phenomenon in amygdala-kindled cats. 365 30

A clinico-pathological entity of progressive neuronal degeneration of childhood with liver disease has now been recognised. Onset is in early childhood with intractable fits and progressive dementia. EEG/ERG/VEP studies have been carried out in 12 children with this condition. In most patients the EEG showed strikingly similar and unusual abnormal patterns (high amplitude slow activity together with smaller polyspikes). The flash VEP was usually abnormal and often asymmetrical. In the appropriate clinical setting the neurophysiological features are sufficiently characteristic to aid the clinician in early diagnosis of this autosomal recessive disorder.
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PMID:Progressive neuronal degeneration of childhood with liver disease ("Alpers' disease"): characteristic neurophysiological features. 372 91

In previous experiments, it was demonstrated that convulsions kindled from a ventral hippocampal focus in rats supported state-dependent learning which tended to lateralized to, and asymmetrical in, the right hemisphere. The question of the differential contribution of the left and right hippocampus to the production of state-dependency can best be addressed through confining the seizure to one or the other hemisphere via commissurotomy. In the present investigation, then, commissurally-intact and split-brain rats were implanted with bilateral hippocampal electrodes, then a left or a right focus was kindled. Later behavioral testing in an aversive inhibitory avoidance (IA) paradigm, revealed that intact animals, both left and right kindled groups, displayed good state-dependency. Split-brain animals, however, exhibited differential state-dependent responses to convulsive stimulation. Those kindled in the left hippocampus showed good retention when the conditions of seizure during training and testing were the same (same-state conditions), while showing deficient recall in changed-state conditions (a good state-dependent profile). On the other hand, those kindled in the right hippocampus displayed good retention of the IA experience in both same- and changed-state conditions. Differential recall after a left versus a right hippocampal convulsion in split-brain animals could not be accounted for in terms of differential seizure parameters, laterality of afterdischarge, extent of extracommissural damage or the extent of the actual transection. Possible mechanisms underlying this effect were discussed.
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PMID:Lateralized state-dependent learning produced by hippocampal kindled convulsions: effect of split-brain. 400 Nov 85

Rabbit intestinal glucoamylase-maltase was examined in detail with respect to its molecular weight, sedimentation, diffusion and viscosity. It is a large asymmetrical molecule, with a molecular weight of 750 000-760 000. Its appearance under the electron microscope supports the idea that it is a long string (62.0 nm) consisting of eight beads of diameter 6.0 nm each and a surface-to-surface interbead distance of approx. 2.0 nm. The shape of the enzyme derived from its hydrodynamic behaviour by using the string-of-spherical-beads model originally proposed by Kuhn [(1932) Z. Phys. Chem. Abt. A 161, 1-32] and later modified by Shulman [(1953) J. Am. Chem. Soc. 75, 5846-5852] fits moderately well with the electron-microscopic picture. The beads might represent about six subunits, and the absence of sulphur from the enzyme and the inability to dissociate the enzyme by conventional methods indicate the possibility of unusual covalent cross-linking between the subunits and between the beads.
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PMID:Studies on the size and shape of rabbit intestinal glucoamylase-maltase complex. 641 89

Effects of midline bi-section including corpus callosum and hippocampal commissure on the kindled generalized convulsion and postictal refractory period (PRP) were examined in temporal cortical kindled cats. Time latency for re-appearance of generalized convulsion after the initial generalized convulsion was designated as a PRP arbitrarily in this experiment. Six repeated electrical stimulation at afterdischarge threshold intensity with one hour interval was performed, and EEG was recorded during PRP test session. Following results were obtained: 1) Kindled generalized convulsion in the split brain cats was characterized by asymmetrical or hemi-convulsion with lateralized afterdischarge in the stimulated hemisphere, 2) EEG silence and monorhythmic 2.5-3 cps high voltage slow activity in the split brain cats did not differ, rather prolonged than the control group in duration, but such postictal EEG changes were lateralized only in the stimulated hemisphere. Behavioral suppression was reduced markedly by midline bi-section, as compared with intact control, 3) In the PRP session of the split brain cats, the initially induced hemi-convulsion appeared with lateralized active afterdischarge lasting for 76.8 sec in the stimulated hemisphere. It was followed by the postictal EEG change as mentioned above in the stimulated hemisphere. In spite of such full-blown ictal events in the stimulated hemisphere, PRP was shorter (within 2 hrs) in the split brain cats than the control cats (more than 4 hrs). It is concluded that midline bi-section including corpus callosum and hippocampal commissure not only modify the pattern and duration of kindled generalized convulsion, but markedly reduce a seizure intensity reflected by shortening of postictal behavioral suppression and PRP.
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PMID:[Effects of callosal bi-section on temporal cortical seizure and postictal refractory period in kindled cats]. 712 77

The prognostic value of early neonatal continuous electroencephalographic recordings in hypoxic ischaemic encephalopathy was evaluated. Thirty seven full term infants with hypoxic ischaemic encephalopathy were studied. The electroencephalogram (EEG) was recorded using four or eight channel Oxford Medilog recorders and was started as soon as possible after birth. The recordings were initially visually analysed and divided into four categories: three in relation to the grade of discontinuity of the background activity (continuous, discontinuous, and maximum depression) and an additional fourth category to include status epilepticus. The EEGs with discontinuous activity were then analysed by computer to obtain a more objective assessment of discontinuity. The results were related to neurological outcome. Continuous background activity was associated with a normal outcome in all but the three infants who had continuous, but asymmetrical EEGs and who developed contralateral hemiplegia. In the eight infants with discontinuous activity, the outcome appeared to be related to the grade of continuity and the presence of clear convulsions on the EEG. The 10 infants with maximum depression and status epilepticus had severe impairment. These preliminary results suggest that continuous recording of EEGs could be used routinely in term infants with hypoxic ischaemic encephalopathy. Computer analysis can improve the value of this technique, allowing the identification of infants who might benefit from early therapeutic intervention.
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PMID:Prognostic value of continuous electroencephalographic recording in full term infants with hypoxic ischaemic encephalopathy. 797 86

To maximize tibial coverage during total knee arthroplasty, a study was performed to evaluate the morphology of the proximal tibia at the resection level and assess tibial coverage with respect to existing tibial implants. Unmagnified radiographs of 42 tibial resection specimens were produced and digitized with existing tibial implants from the asymmetrical Genesis and the symmetrical Insall-Burstein II and Press Fit Condylar total knee arthroplasty designs. The average total profile coverage ranged from 80.62% to 84.73%, whereas the average posteromedial coverage ranged from 76.05% to 82.09%. The shape of the tibia at the resection level was asymmetrical, and the overall tibial coverage was never greater than 85%. It appears that the actual shape of the tibial tray and the number of accommodating sizes provide the best ability of a total knee arthroplasty system to maximize tibial coverage, and not simply an asymmetrical or a symmetrical design.
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PMID:Resection specimen analysis of tibial coverage in total knee arthroplasty. 799 56

The kinetics of water vapor absorption-desorption was studied in the porcine stratum corneum (sc) at 25 degrees C. Dry sc samples were exposed to several relative humidities followed by exposure to dry air, and the change in weight was monitored over time by use of a thermal gravimetric analysis technique. Diffusion coefficients were estimated by simulation and data fit optimization to modifications of the non-steady-state solution of Fick's law. Very good fits of experimental data to theoretical equations were obtained. The stratum corneum-water absorption isotherm was characterized by a linear increase from the origin, extending to about 55% relative humidity (10% water gain), followed by an upward curve where water gain increased further by increasing relative humidity. Water absorption and water desorption in the porcine sc were asymmetrical processes, desorption being the slower one. Water diffusivity for the absorption process was related to sc water content in two phases. In the first (water gain < 9%) diffusion coefficients increased as water concentration increased. In the second (water gain > 9%) diffusion coefficients were independent of water concentration, equal to 1.17 x 10(-10) cm2/s. Water diffusivity in the desorption phase was shown to decrease linearly as sc water content decreased. Analysis of the absorption isotherm and of the derived diffusion coefficients suggested at least two forms of water associated with the sc. The first, termed "firmly bound water" and characterized by low diffusion coefficients, was most apparent with dry sc and with a sc water gain of up to 10%.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Kinetics of water vapor sorption in porcine stratum corneum. 807 23

Benign neonatal familial convulsions comprise a distinct epileptic syndrome with an autosomal mode of transmission. The electroclinical signs of seizures in this syndrome are not yet well defined. In 3 children from two families presenting with benign neonatal familial convulsions, 14 seizures were recorded during electroencephalographic (EEG)-video sessions. All seizures occurred during sleep, after a short arousal reaction. Seizures started with bilateral, symmetrical flattening of the EEG for 5 to 19 seconds; simultaneously there was apnea and tonic motor activity. The EEG flattening was followed by a long (1-2-minute) bilateral discharge of spikes and sharp waves; simultaneously, there were vocalizations, chewing, and focal or generalized clonic activity. The prominence of EEG and motor abnormalities varied between the left and the right from one seizure to the next in any given child. The seizures stopped without EEG or clinical postictal depression. These electroclinical observations suggest that the convulsions of benign neonatal familial convulsions are a form of generalized tonic-clonic seizure whose expression may be asymmetrical, probably because of the immaturity of the corpus callosum or other structures ensuring seizure synchronization.
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PMID:Electroclinical signs of benign neonatal familial convulsions. 825 May 33

1. We have studied the block by intracellular Mg2+ (0.08-4mM) of ATP-dependent potassium channels (KATP channels) from rat skeletal muscle using inside-out excised sarcolemmal patches. The block is voltage dependent, is relieved by extracellular potassium and has rapid kinetics, allowing the use of amplitude distribution analysis to estimate on and off rates. 2. To gain insight into the pore properties necessary to produce such a block, we have used an energy barrier model based on Eyring rate theory. The model has two energy wells and three barriers for K+ within the pore, while intracellular Mg2+ has access only to the inner well. We fitted the model to unitary current-voltage relations in different [Mg2+], to on and off rates, and to dissociation constants for Mg2+ block. 3. The voltage dependence of block was almost entirely due to the rate constant for unblocking. This implies that the inner energy barrier is asymmetrical, so that Mg2+ entry senses little of the voltage field, but Mg2+ exit senses about 20% of the voltage field. Best fits were obtained by placing the barrier and binding site 0.01 and 0.22, respectively, of the electrical distance through the pore from the inside. 4. The relief of block by [K+]o resulted from an increase in the unblocking rate for Mg2+, implying ionic repulsion between ions in the pore.
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PMID:A rate theory model for Mg2+ block of ATP-dependent potassium channels of rat skeletal muscle. 868 79


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