Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The case of a 5-month-old black female child with a linear sebaceous naevus syndrome and multiple congenital anomalies is presented. Ocular malformations consisted of colobomatous changes of the lid and retina, dermoid of the conjunctiva, chorioretinal changes, and peripapillary atrophy of the optic nerve. Systemic findings included midline cleft of the secondary palate with involvement by the naevus, bilateral hearing loss, asymmetrical skull bones, ventricular septal defect, epidermal inclusion cyst, and developmental delay without seizures.
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PMID:Ocular findings in linear sebaceous naevus syndrome. 358 Mar 38

Morphogenesis of avian conjunctival papillae follows a predictable temporal and spatial pattern and is in some manner directly related to the introduction of the underlying scleral ossicles. We have been able, using Scanning Electron Microscopy (SEM), to correlate all of Murray's ('43) histological stages (1--6) of papillae development, with changes in elevation and morphology of the surface of the conjunctiva. The first indication of morphogenesis is the formation of "papillae primordia." The centers of these primordia exhibit decreased intercellular contact, and become elevated as radially symmetrical humps whose surfaces are composed of rounded cells with numerous microvillar projections. As the papillae become asymmetrical and elongate, cells near the tip of the papillae enlarge and develop microridges. During regression of the papillae, single clusters of cells appear to become lost from the surfaces of the papillae into the surrounding fluid. In contrast to normal chick embryos, those homozygous for papillae and underlying scleral ossicles (Palmoski and Goetinck, '70). SEM of the mutant conjunctival surface indicates that these papillae do not exhibit all of Murray's ('43) histological stages and are morphologically abnormal. Data from the present SEM study of the normal and scaleless conjunctiva are discussed in relation to those data of other investigators, and we suggest that Stage 4 in papillae development is critical to scleral ossicle formation.
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PMID:Morphogenesis of conjunctival papillae from normal and scaleless chick embryos. 721 23

Vernal keratoconjunctivitis (VKC) is a chronic, bilateral, at times asymmetrical, seasonally exacerbated, allergic inflammation of the ocular surface, involving tarsal and/or bulbar conjunctiva. Though the allergic nature of this entity has been accepted for a long time, the accumulation of a large amount of immunological data has proved that the pathogenesis of VKC is much more complex than a mere type 1 hypersensitivity reaction. In the past several years, many clinical and experimental studies about the cells and mediators involved in initiating and perpetuating the ocular allergic inflammation have shown that T helper type 2 cells and their cytokines, corneal fibroblasts and epithelium along with various growth factors play an important role in the pathogenesis of VKC. Based on this information about the pathogenesis of VKC newer, more selective drugs like anti-chemokine receptor antibodies and leukotriene receptor antagonists are under evaluation. Cyclosporine has been shown to be effective in the treatment of VKC but further randomized control trials are required to establish the minimum effective concentration.
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PMID:Vernal keratoconjunctivitis: a major review. 1878 27

Among primates, only humans have the white sclerae that provide the ground necessary to display their own color and that of the overlying conjunctiva. Scleral color, primarily redness, provides cues of socially and biologically significant information about an individual. The present study examines the effect of the asymmetry of binocular scleral redness on perceived sadness, healthiness, and attractiveness by contrasting ratings of images of individuals who had one, both, or neither sclera reddened by digital editing. Building upon previous research, this study further defines the details of the scleral color display and contributes to the more general issue of facial and body symmetry, predictors of phenotypic condition and genotypic quality that are of interest to evolutionary theorists. Individuals with binocular and monocular redness were rated as sadder, less healthy, and less attractive than those with untinted control sclerae, with ratings corresponding to the degree of redness or whiteness. Bilaterally symmetrical (binocular) scleral redness or whiteness provided anchorage points for ratings, with ratings for bilaterally asymmetrical (monocular) redness or whiteness falling between them; there was no unique effect of asymmetry.
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PMID:Binocular symmetry/asymmetry of scleral redness as a cue for sadness, healthiness, and attractiveness in humans. 2395 71