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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this study was to determine the consistency of reflex responses of subjects in varying behavioral states. The following selected primitive reflexes were examined in children with spastic quadriplegic cerebral palsy: tonic labyrinthine, asymmetrical tonic neck, symmetrical tonic neck, crossed extension, and Moro. Our hypothesis was that a subject's reflex responses would vary as a function of his behavioral state. Ten children, ages 3 to 6 years, participated in the study. Reflex responses were elicited using a specified protocol. A behavioral-state scale was defined, and the subject's behavioral state was noted before each reflex stimulus was applied. Each subject completed eight test sessions. Test sessions were videotaped with portable video equipment. Results of the study indicated a significant inverse relationship between progression on the behavioral-state scale and consistency of reflex responses; the higher the numerical rating, the less the consistency of response. Findings of our study support those who recommend optimal states for testing and indicate that caution should be used when interpreting test results based on a single examination.
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PMID:Selected primitive reflexes in children with cerebral palsy: consistency of response. 710 Feb 70

Twenty-six children with cerebral palsy were examined with respect to structural asymmetry of the mouth. In 19 children there were clear cut correlations between symmetry/asymmetry of voluntary function and the oral findings. Patients with symmetrical patterns of movements had symmetrical dentition, while in those with asymmetrical function the favoured side corresponded to the side with structural changes. Apparent exceptions to this rule in 7 children could be resolved in 6 by analysis of their complex case histories. Fifty normal controls showed oral asymmetries of nearly identical frequency and magnitude. In this respect there is no difference between the normal and handicapped group.
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PMID:Asymmetry in children with cerebral palsy and oral structure. 744

To evaluate the topographical neurological distribution, patterns of abnormal tone and related functional neuromotor impairment after grade 3 and grade 4 intraventricular/periventricular haemorrhage (IPVH), 33 children with previous grade 3 or 4 IPVH of mean gestational age 30.9 weeks (range 25-40 weeks) and mean birth weight 1743 g (range 866-3600 g) were examined neurologically at 4.7 years (range 0.75-10.8 years). Neurological signs were absent in 10/33 cases which were equally distributed between the grade 3 and grade 4 IPVH groups. The largest single topographical neurological distribution was hemiparesis in 8/23, followed jointly by diplegia (cerebral paraplegia) in 6/23 and triplegia in 6/23 cases and finally quadriplegia in 3/23 cases. Grade 4 IPVH tended to result in asymmetrical syndromes, accounting for 7/8 cases of hemiparesis and 5/6 cases of triplegia, whereas all 3/3 cases of quadriplegia followed grade 3 IPVH. The 6/23 cases of diplegia were shared between the grade 3 and grade 4 IPVH groups. Tone was normal in 7/8 of the hemiparetic subjects. Dystonia was the commonest tone abnormality, affecting 8/23 children with neurological disturbance, followed by ataxia/hypotonia in 4/23 and mixed dystonia/hypotonia in 3/23. Only 1/23 cases had signs of spasticity. Spasticity is rare following severe IPVH. Diplegic children had a better functional neuromotor grade than hemiparetic children, who in turn did better than triplegic children. Ataxia hypotonia resulted in better functional outcome than dystronia, which in turn was more favourable than mixed tone patterns. Cranial imaging by ultrasound (US) or computed tomographic (CT) scanning proved an unreliable prognostic indicator except in the case of hemiparesis, for which US scans correctly predicted the affected side in 5/7 cases. The neurological syndromes following severe IPVH differ from the classical encephalopathy of prematurity, and this should lead to a re-appraisal of the trends in the prevalence of cerebral palsy. Caution should be exercised in the interpretation of cranial imaging with regard to pessimistic prognoses in the presence of changes or undue optimism in their absence.
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PMID:Heterogeneity of neurological syndromes in survivors of grade 3 and 4 periventricular haemorrhage. 840 2

A new physical therapy, Ueda method (UM), were performed on two patients with severe motor and intellectual disabilities syndrome and spastic cerebral palsy (CP). The period of the UM therapy was 5 days in one case with spastic CP and 10 days in another case with rigo-spastic CP. They showed the remarkable reduction of abnormal muscle tone and interesting phenomena such as postural changes of extremities and changes of some primitive reflexes. First, peculiar postures of treated extremities appeared on the first day of the UM therapy, associated with the reducing muscle tone of extremities only in the treated side. One case showed immediate change of the posture of treated upper extremity from internal to external rotation of the shoulder joint. Another case disclosed immediate appearance of internal rotation of the hip joint of the treated lower extremity and scissoring posture of legs. These phenomena were transient and disappeared under the UM treatment. Secondly, interesting phenomena in some primitive reflexes were observed after the beginning of the UM therapy. Moro reflex was elicited only in the treated upper extremity, which could not be obtained by stimuli before the UM therapy. After the UM therapy on bilateral arms. Moro reflex appeared bilaterally in two cases. On the other hand, the degree of asymmetrical tonic neck reflex (ATNR) in one case with spastic CP reduced on 5th days under the UM therapy. In another case with rigo-spastic CP automatic walking disappeared on 3rd days after the UM therapy and ATNR appeared. The first phenomena could be due to imbalances of the reduced muscle tones by the UM therapy. Second phenomena could result from the interaction between the nervous systems of Moro reflex, ATNR and automatic walking and the nervous system owing to the abnormal muscle hypertone. Moro reflex might be suppressed by abnormal muscle hypertone. The disappearance of some primitive reflexes might not depend on the maturation of the central nervous system.
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PMID:[What change was caused under short-time treatment by the Ueda method for severely disabled infants with cerebral palsy? Report of two cases]. 943 13

One hundred and fifty-three infants were assessed by a method specific to preterm infants and appropriate to the intensive-care nursery environment. The presence or absence of six atypical features (coarse jitters, dominant asymmetrical tonic neck reflex, paucity of movement, 'contradictory' development, hypotonia, or hypertonia) resulted in neonatal classification. There were 116 'usual' (an absence of atypical features with progressive development), 26 'unusual' (a transient occurrence of any atypical feature), and 11 'suspect' (dominance of one or more atypical features). At 6 years of age the motor subsystems of balance, coordination, fine and gross motor, and associated movements were assessed. Nine of 11 children with cerebral palsy had neonatal categories of 'suspect' (7) and 'unusual' (2), of the remaining four other 'suspect' children, two failed two motor subsystems and two failed motor items. A 'usual' neonatal assessment predicted normal motor outcome for 72 of 116 (62%) whereas a 'suspect' assessment predicted major motor dysfunction for seven of 11 of the children.
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PMID:Assessment of preterm infants in the intensive-care unit to predict cerebral palsy and motor outcome at 6 years. 963 Feb 58

We describe 8 patients who presented with continuous, irregular movements occurring independently in individual fingers and, in some cases, toes, in the setting of mild dystonia present since early childhood and not associated with major disability. The finger movements varied from low-amplitude quivering or wriggling to larger amplitude movements in the plane of abduction-adduction as well as flexion-extension; they were asymmetrical but not unilateral. Quivering or working of the facial muscles was seen in 5 patients. Most patients reported worsening of the movements over the years, but there was no other evidence of a progressive neurological disease. We classify the movement disorder as athetosis as described by Hammond and Shaw and the syndrome as mild athetoid cerebral palsy.
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PMID:Athetosis II: the syndrome of mild athetoid cerebral palsy. 1246 69

Some children with mild cerebral palsy have articulation disorders that are resistant to conventional speech therapy techniques. This preliminary study investigated the use of electropalatography (EPG) to diagnose and treat a long-standing articulation disorder that had not responded to conventional speech therapy techniques in an 8-year-old boy (D) with a congenital left hemiplegia. The targets for EPG therapy were speech errors affecting velar targets /k, g, eta/, which were consistently fronted to alveolar placement [t, d, n]. After 15 sessions of EPG therapy over a 4-month period, D's ability to produce velars improved significantly. The EPG data revealed two features of diagnostic importance. The first was an unusually asymmetrical pattern of tongue-palate contact and the second was unusually long stop closure durations. These features are interpreted as a subtle form of impaired speech motor control that could be related to a mild residual neurological deficit. The results suggest that EPG is of potential benefit for diagnosing and treating articulation disorders in individuals with mild cerebral palsy.
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PMID:Using electropalatography (EPG) to diagnose and treat articulation disorders associated with mild cerebral palsy: a case study. 1294 12

The concurrent validity of a 1 minute walk test at a child's maximum walking speed was assessed in children with bilateral spastic cerebral palsy (BSCP). The distance covered during the 1 minute walk test was compared with the children's gross motor function as assessed by the Gross Motor Function Measure (GMFM). Twenty-four male and 10 female children with CP (mean age 11y, range 4 to 16y) participated in the study. Gross Motor Function Classification System (GMFCS) levels were; level I (n=3), level II (n=17), level III (n=10), and level IV (n=4). Participants had clinical diagnoses of symmetrical diplegia (n=19), asymmetrical diplegia (n=14), and quadriplegia (n=1). Results showed a significant correlation between GMFM score and the distance covered during the 1 minute walk (r=0.92; p<0.001). There was also a significant decrease in the distance walked with increasing GMFCS level (p<0.001). We concluded that the 1 minute walk test is a valid measure for assessing functional ability in children with ambulatory BSCP. Its cost-effectiveness and user friendliness make it a potentially useful tool in the clinical setting. Further study needs to address its reliability and ability to detect change over time.
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PMID:Validity of a 1 minute walk test for children with cerebral palsy. 1622 37

This study applies an upper extremity model to analyze motion in 25 children with cerebral palsy using posterior walkers. The study indicates that throughout a gait cycle, the shoulders and wrist are in extension and the elbows are flexed. It also reveals that the elbows are the most asymmetrical joint of the upper extremities during walker-assisted ambulation.
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PMID:Kinematic analysis of upper extremity joint motion in children using posterior walkers. 1727 65

Deformities in the child with cerebral palsy have been ascribed to muscle imbalance (Sharrard 1961) and increased tone (Pollock 1959) or to the type of cerebral palsy (Bobath and Bobath 1975). As far as we know, the position in which the child is nursed, especially during the first year of life, has not been considered as a cause of deformity. It is generally agreed that position in the postnatal period can be a cause of deformity in the normal baby. Paine (1961) suggested that plagiocephaly was caused by postnatal head posture, and Hay (1971) found that plagiocephaly was present in 10 percent of normal babies. Scott (1956) reported that infants commonly had lateral curvatures of the spine which could be seen on x-rays but not on clinical examination, all of which had resolved by the age of two years. Other asymmetries associated with plagiocephaly are unilateral fisting, asymmetrical groin creases, apparent shortening of one lower limb and asymmetry of gait (Robson 1968). We accept the asymmetrical deformities of plagiocephaly, unilateral bat ear, facial and thoracic asymmetry, pelvic obliquity and apparent shortening of one leg--some or all of which may be present in normal babies--as forming the 'squint' baby syndrome. Because asymmetrical deformities also occur in children with cerebral palsy, we thought it worthwhile to compare the pattern of deformity in a group of 'quint' but otherwise normal babies with a group of cerebralpalsied children with asymmetrical deformities to see if there is any relationship.
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PMID:Position as a cause of deformity in children with cerebral palsy (1976). 93 45


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