Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A cDNA encoding a potassium channel of the two-pore domain family (K2p) of leak channels was cloned from the CNS of the marine opisthobranch Aplysia californica. This is the first sequence of the K2p family identified in molluscs and has been named AcK2p1. The deduced amino acid sequence is homologous to channels of the mammalian two-pore domain halothane inhibited (THIK) subfamily, bearing 46% identity to THIK-1 (KCNK 13) and 48% to THIK-2 (KCNK12). We used in-situ hybridization to analyze the distribution of this class of channels in the CNS. AcK2p1 is specifically expressed in many central neurons of all major ganglia including the largest identified neurons MCC, R2 and LP1. The highest expression of AcK2p1 was detected in an asymmetrical and distinct cluster of up to 30 cells located at the dorsal-medial region of the right pleural ganglion. The neuron-specific distribution seen in the molluscan CNS is consistent with data from mammals that indicate THIK is only expressed in restricted neuronal populations, suggesting its involvement in both the maintenance of neuronal phenotype and in the specific functional role of these neurons in their respective networks.
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PMID:Identification and distribution of a two-pore domain potassium channel in the CNS of Aplysia californica. 1530 18

Background: The pterygoid fovea on the mandibular neck is superomedial to the mandibular notch and serves to attach the lateral pterygoid muscle. Clinical presentation: During a retrospective cone beam computed tomography study, a 67-year-old male patient was found to exhibit a peculiar variant that contradicted normal anatomy. The patient's mandibular condyles were asymmetrical in terms of their shapes and sizes, although their lateral poles (lateral condylar tubercles) were both prominent. On the left side, the lateral condylar tubercle had a second, or accessory, pterygoid fovea, which was located outside the mandibular notch. Further, the left lateral pterygoid muscle was attached to the entire width of the mandibular condyle, including the accessory fovea. Clinical significance: Such rare anatomical variants lead to asymmetrical temporomandibular joints, although their occurrence has not previously been reported. Thus, they should be further documented in clinical studies of temporomandibular joint dysfunction. Abbreviations: LPM: Lateral pterygoid muscle; MC: Mandibular condyle; PF: Pterygoid fovea; TMJ: Temporomandibular joint; MCC: Mandibular condylar cartilage; MPR: Multiplanar Reconstruction; VC: Vascular canal.
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PMID:Accessory pterygoid fovea of the human mandibular condyle. 3124 Oct 1