Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recurrent episodes of seronegative asymmetrical arthritis usually lasting less than a week have been observed in 4 patients with beta thalassemia minor. In one case, irreversible joint damage of a wrist joint occurred 14 years after the onset of the rheumatism. Studies of the synovial fluid and synovial membrane performed in 2 cases revealed signs of moderate inflammation. The main differential diagnosis was from microcrystalline synovitis and palindromic rheumatism which was ruled out by clinical and laboratory data.
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PMID:Recurrent episodes of arthritis in thalassemia minor. 661 Jul 57

Arthritis of the terminal joints of the hands and feet occurred more frequently (P less than 0.015) in patients with seronegative poly-arthritis combined with psoriasis (S- P+; n = 92) than in patients with seronegative polyarthritis alone (S- P-; n = 72). However, the prevalence of affection of these joints was too low to consider this feature a sensitive marker for psoriatic arthritis. Furthermore, neither asymmetrical joint involvement nor the absence of ulnar deviation of the fingers appeared to be characteristic of this disease. A positive correlation was found between the presence of nail psoriasis and limitation of function of the distal interphalangeal (DIP) joints. The DIP finger joints and the interphalangeal joints of the toes were affected more often in the S- P+ group than in patients with seropositive polyarthritis without psoriasis (S+ P-; n = 46), but arthritis of the other joints was observed more frequently in the latter group.
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PMID:Psoriasis and arthritis. II. A cross-sectional comparative study of patients with "psoriatic arthritis" and seronegative and seropositive polyarthritis: clinical aspects. 661 Sep 13

Radiological changes depend on the age of onset as well as the pattern of disease present (Ansell & Kent 1977). Seronegative disease tends to be associated with modelling abnormalities of the epiphyses, loss of joint space and the late development of erosions, although an occasional polyarthritis following systemic disease has a very destructive arthritis and overall failure of growth. Pauciarticular disease is associated with growth anomalies of epiphyses and also metaphyses in asymmetrical fashion. In spondylitic children, enthesiopathies are marked and there is a high incidence of hip involvement. Seropositive juvenile rheumatoid arthritis shows a severe erosive arthropathy early, combined with minor growth changes, particularly bony overgrowth in the hands and feet in the early teens. The hallmark of the psoriatic is the asymmetry and, in a few cases, the destructive nature of asymmetrically involved joints.
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PMID:Uncommon radiological features of chronic arthritis in childhood: a review. 703 33

Human leukocyte proteins from more than 150 patients with rheumatoid arthritis, together with age- and sex-matched controls, were analyzed by use of the ISO-DALT technique in two-dimensional polyacrylamide gel electrophoresis. Patients with ankylosing spondylitis, polymyalgia rheumatica, psoriatic arthritis, calcium tendinitis, post-infectious arthritis, and asymmetrical seronegative arthritis were also included as positive controls. Synthesis of several proteins, referred to by number as members of the "Rheuma" set, is shown to increase in the leukocyte preparations from patients with classical rheumatoid arthritis. Several of these proteins are specific to monocytes or granulocytes; others are of unknown cellular origin, but appear to be unique to rheumatoid arthritis. The Rheuma proteins appear to be indicators of disease activity, because their increased synthesis can be correlated with sedimentation rate and other clinical indices of rheumatoid disease activity.
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PMID:Two-dimensional electrophoretic analysis of human leukocyte proteins from patients with rheumatoid arthritis. 707 65

We report the case of a 65-year-old patient with a 15-year history of intermittent asymmetrical oligoarthritis, who subsequently developed splenomegaly, lymphadenopathy, and episodic leucopenia and thrombocytopaenia. Investigations revealed hairy cell leukaemia, and 'hairy cells' were detected in the synovial fluid. No other cause for this arthritis was found, and we consider the blood dyscrasia to be the likely cause. This case demonstrates a hitherto unreported association between arthritis and hairy cell leukaemia.
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PMID:Arthritis associated with hairy cell leukaemia. 709 43

Seventy-three patients with systemic lupus erythematosus were examined, in 55 (75%) of whom involvement of the temporomandibular joint was detected, this involvement occurring at the debut of the disease, before involvement of other joints, in 44 subjects. The disease presented as ephemeral migrating asymmetrical arthralgia, more expressed by the evening hours, and, rarely, as temporomandibular arthritis and painful (functional) contractures. A frequent dissociation between the clinical and x-ray signs of the disease, no residual phenomena were observed. X-Ray examination can effectively rule out other diseases of the temporomandibular joint, first of all, destructive genesis.
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PMID:[The involvement of the temporomandibular joints in systemic lupus erythematosus]. 748 8

The case of a 63 year old woman with mesenteric recurrence of a colonic carcinoma and infiltration of the duodenum is reported. To bypass duodenal stenosis a duodenojejunostomy was performed. Three months later the patient developed severe atypical polyarthritis which led to hospitalization. The arthritis affected large and small joints in an asymmetrical pattern. Fever and Raynaud's phenomenon of both hands accompanied the arthritis. Elevated sedimentation rate, acute phase proteins, cryoglobulinemia and immune complexes were remarkable laboratory findings. Rheumatoid factor was absent. In the subsequent course the polyarthritis was refractory to steroids and nonsteroidal anti-inflammatory drugs. Only treatment with broad-spectrum antibiotics ameliorated the arthritis. Postenteric reactive arthritis, septic arthritis and metastatic arthritis could be excluded. Although the patient had a family history of rheumatoid arthritis and a HLA-type DR4 the diagnosis of rheumatoid arthritis was not very likely since distal interphalangeal joints were affected, rheumatoid factor was absent and antibiotic therapy was successful. The case serves to discuss carcinoma-polyarthritis and bypass-arthritis as the main differential diagnosis.
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PMID:[Therapy refractory atypical polyarthritis and cryoglobulinemia in a patient with colon carcinoma and palliative intestinal bypass. Differential diagnosis: carcinoma-polyarthritis or bypass arthritis]. 748 38

The interval between the appearance of the symptoms of psoriasis and/or arthritis and the setting up the diagnosis of the psoriatic arthritis was studied in 215 patients suffering from definite psoriatic arthritis. About 2.3 years were over until the setting-up of the diagnosis in these 30 patients whose psoriasis and arthritis began simultaneously. The interval to set up the diagnosis of psoriatic arthritis was 5.4 years in average if the psoriasis itself was the first sign and it was 8.6 years in case the arthritis preceded psoriasis. The symptoms promoting to set up the right diagnosis were in order to frequency as follows: appearance of psoriasis, sausage digits, distal interphalangeal involvements, nail changes and transformation the monoarthritis into asymmetrical oligoarticular or polyarticular form. The difficulty of the differential diagnosis was studied. 15 different previous false diagnoses were enumerated the rate of which was the highest (67.3%) in the group starting with arthritis. The authors call the attention to the importance of looking for psoriatic skin and nail changes in every nonclassified arthritic patient in the interest of an early diagnosis and right therapy in course of the follow-up.
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PMID:[Diagnosis and differential diagnosis of psoriatic arthritis on basis of follow up of 215 cases]. 764 86

A cross-sectional study of arthritis was conducted in the Rheumatology Department of the Brazzaville Teaching Hospital, Congo. A total of 473 patients with arthritis seen between 1989 and 1991 were subjected to the limited tests available. Gout was the leading diagnosis (n = 83). Septic arthritis (n = 82) and infectious discitis (n = 55) were the most common reasons for admission. Tests often failed to identify the causative organism; Staphylococcus was the most commonly recovered organism. Tuberculous discitis was less common than discitis due to pyogenic bacteria. HIV-related arthritis (n = 57) usually manifested as severe, febrile, asymmetrical, nonerosive, polyarthritis. Cases of rheumatoid arthritis (n = 29) fit the classical description of the disease. In 83 patients with monoarthritis, oligoarthritis, or polyarthritis, no etiology could be identified.
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PMID:[Diagnosis of arthritis in black Africa. Apropos of 473 cases in Congo]. 792 May 24

The case is reported of a 71 year old man diagnosed as having Type I Ehlers-Danlos syndrome, a condition associated with the premature development of osteoarthritis, who contracted poliomyelitis as a young man as a result of which he has developed asymmetrical osteoarthritis involving the limbs unaffected by the poliomyelitis. This observation lends further support to the hypothesis that an intact neural pathway may be necessary for the development of arthritis.
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PMID:Asymmetrical osteoarthritis in a patient with Ehlers-Danlos syndrome and poliomyelitis. 795 9


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