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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Non-human primates, such as the rhesus monkey, provide excellent models of human fear and anxiety because of similarities in behavioral responses and brain function. Studies of rhesus monkeys demonstrate that animals with an anxious temperament exhibit inappropriately exaggerated responses to fearful situations, extreme asymmetrical electrical activity in the right prefrontal cortex, and dysregulation of the corticotropin-releasing factor system. Similar findings have been observed in anxious or behaviorally inhibited children who are at greater risk of developing anxiety disorders later in life. Characterization of distinct behavioral and neurobiological features in anxious rhesus monkeys may one day form the basis of tools to identify children who are at risk to develop anxiety disorders and other stress-related problems later in life. Psychopharmacology Bulletin. 2004;38(Suppl 1):8-13.
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PMID:Studying non-human primates: a gateway to understanding anxiety disorders. 1527 12

The approach-withdrawal model of hemispheric activation suggests that left frontal cortical areas mediate approach, while right frontal cortical areas mediate withdrawal motivation. Within this framework, the present study investigates the association of frontal cortical asymmetry with attentional and emotional responses toward approach- and withdrawal-related emotional stimuli. Resting frontal asymmetry was measured from 43 students before they passively viewed negative, neutral, and positive emotional pictures. The startle reflex, skin conductance response, and subjective ratings of valence and arousal were assessed to quantify emotional responding, while attention was assessed with ERPs. We also assessed frontal asymmetry in response to the pictures. Results indicated that relatively stronger right frontal cortical activation was associated with increased N1 amplitudes and more negative subjective emotional evaluation of all stimuli. Furthermore, enhanced right frontal asymmetry (state and trait) was associated with diminished emotional modulation of the late positive potential. In contrast, no association of frontal asymmetry with defensive reflex physiology or activation of sympathetic nervous system activity was found. The current data suggest dissociable influence of resting frontal brain asymmetry on attentional and physiological processing of withdrawal- and approach-related stimuli. That is, asymmetrical frontal cortical brain activation might not modulate approach-/withdrawal-related motor responses and sympathetic arousal directly, but instead enhances allocation of attentional resources to subjectively significant stimuli. The results are discussed in terms of their potential importance for emotion perception in anxiety disorders and their contribution to the understanding of frontal asymmetry.
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PMID:The influence of frontal alpha-asymmetry on the processing of approach- and withdrawal-related stimuli-A multichannel psychophysiology study. 2844 63