Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The organophosphorus insecticide dicrotophos injected at 4 days of incubation into the yolk sac of hen'eggs determined achondroplasia with tibiotarsus deformities. These malformations were studied at different stages of embryogenesis using different histological methods. After injecting 0,5 mg per egg, the size of the hindlimbs was decreased by 50% and the growth was much less (from 20 to 30% of the normal) When giving the toxic et the level of 1 mg per egg. Light and electron microscopical observations showed a reduction or a lack of the proliferative zones and a decrease in the secretory activity of the chondrocytes which may possibly be related to the growth retardation. Using adaptated techniques for mineralized tissue examination and scanning microscope, a disorganized and an asymmetrical deposition of the periosteal osseous lamellae was observed.
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PMID:[Teratogenic effect of dicrotophos on the embryonic chick tibia ; histological and cytological studies (author's transl)]. 53 84

When walking, step length provides critical information on traveled distance along the ongoing path [corrected] Little is known on the role that knowledge about body dimensions plays within this process. Here we directly addressed this question by evaluating whether changes in body proportions interfere with computation of traveled distance for targets located outside the reaching space. We studied locomotion and distance estimation in an achondroplastic child (ACH, 11 yr) before and after surgical elongation of the shank segments of both lower limbs and in healthy adults walking on stilts, designed to mimic shank-segment elongation. Kinematic analysis of gait revealed that dynamic coupling of the thigh, shank, and foot segments changed substantially as a result of elongation. Step length remained unvaried, in spite of the significant increase in total limb length ( approximately 1.5-fold). These relatively shorter strides resulted from smaller oscillations of the shank segment, as would be predicted by proportional increments in limb size and not by asymmetrical segmental increment as in the present case (length of thighs was not modified). Distance estimation was measured by walking with eyes closed toward a memorized target. Before surgery, the behavior of ACH was comparable to that of typically developing participants. In contrast, following shank elongation, the ACH walked significantly shorter distances when aiming at the same targets. Comparable changes in limb kinematics, stride length, and estimation of traveled distance were found in adults wearing on stilts, suggesting that path integration errors in both cases were related to alterations in the intersegmental coordination of the walking limbs. The results are consistent with a dynamic locomotor body schema used for controlling step length and path estimation, based on inherent relationships between gait parameters and body proportions.
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PMID:Changes in the limb kinematics and walking-distance estimation after shank elongation: evidence for a locomotor body schema? 1909 16