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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is probable that all schizophrenics have abnormalities in the medial temporal lobe, which differ in degree but not in kind. The structures of the medial temporal lobe are believed to have a crucial role in the integration and processing of the output from the association cortex. Dysfunction of this system could result in the clinical symptoms that form the core of the schizophrenia syndrome. The structural differences appear to fit the profile of a disturbance in the normal pattern of brain development. The asymmetrical patterns of normal brain development explain how such a disturbance simultaneously affecting both hemispheres could, disproportionately, affect the left (dominant) hemisphere. Epidemiological and pathological evidence points to aberrant genetic mechanisms as being the cause of the developmental anomaly in the majority of cases; environmental factors probably play a minor role. Despite the great progress made in solving the enigma of the structural changes in the brains of schizophrenics, the cause(s) of the changes--the aberrant genetic mechanism controlling brain development--may prove difficult to define.
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PMID:Schizophrenia: a neuropathological perspective. 201 55

It has been shown that, in a bilateral force-matching task, subjects presenting weakness in one limb produce a lower force in the weakened limb even though they subjectively perceive that they are exerting the same force. The aim of this study was to verify whether subjects with hemiparesis produced asymmetrical forces during a bilateral submaximal grip task and whether this asymmetry is related to weakness of the paretic limb. Fifteen subjects with hemiparesis and 15 healthy subjects were recruited. First, the maximal voluntary force was measured for each hand. Then, subjects were asked to exert equal forces with both hands simultaneously at three submaximal force levels using two dynamometers. In the bilateral task, the force ratios (paretic/nonparetic or nondominant/dominant) differed between groups. Severely weak hemiparetic subjects produced lower force ratios than mildly weak hemiparetic subjects and healthy subjects (P < 0.000), whereas there was no difference between the force ratios produced by mildly weak hemiparetic subjects and those produced by healthy subjects. In subjects with hemiparesis, the force ratios in the bilateral task were related to the ratios of maximal voluntary forces (R2 = 0.39-0.66, P < or = 0.013) and the presence of somatosensory impairment did not affect these relationships. These results suggest that the strategy used is to compare the intensity of the motor commands on both sides and then perform the force-matching task. The use of such a strategy by subjects who have had paresis for 1 year reflects a lack of adaptation to their weakness.
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PMID:Effects of weakness on symmetrical bilateral grip force exertion in subjects with hemiparesis. 1462 61

In this transcranial magnetic stimulation study, we assessed motor cortex excitability in the resting hemisphere while the homologous side was active during a voluntary unimanual task. Data acquired from left- and right-handers showed that cortical excitability varied as a function of isometric task demands and hand dominance. In particular, facilitation of the motor-evoked potentials was observed across task requirements in left-handers, independent of which hemisphere was active. In right-handers, facilitation was present when the right hemisphere was active whereas this effect was largely reduced when the left hemisphere was active, suggesting pronounced inhibitory interactions from the left (dominant) to the right (non-dominant) hemisphere. The distinct scaling of motor cortex excitability indicates the importance of the left hemisphere in guiding manual control in right-handers whereas both hemispheres are functionally relevant in left-handers. Overall, the results underline the asymmetrical organization of the motor system in right-handers with an important role of the dominant hemisphere whereas symmetrical functional abilities of both hemispheres characterize left-handers.
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PMID:Primary motor cortex and ipsilateral control: a TMS study. 2472 82

Breast asymmetry is common in females, despite a similar driving force; dynamic activity may result in asymmetrical breast motion. This preliminary study investigated how breast categorisation (left/right or dominant/non-dominant) may affect breast support recommendations and its relationship with breast pain. Ten females ran on a treadmill at 10 kph in three breast supports (no bra, everyday bra, sports bra). Five reflective markers on the thorax and nipples were tracked using infrared cameras (200 Hz) during five running gait cycles in each breast support. Multiplanar displacements of both breasts were calculated relative to the thorax. Although the maximum individual participant difference was 2.4 cm (mediolaterally) between the left and right breast, no left/right differences were found in any direction or support condition. Notably, correlations between breast pain and anterioposterior breast displacement were stronger with the left breast (r = 0.614) and moderate with the right breast (r = 0.456). Following participant categorisation according to the greatest magnitude of superioinferior breast displacement (dominant breast), results showed significant differences in displacement for all directions across different breast supports. When using breast kinematic data to examine relationships with breast pain or to recommend breast support requirements, data on both breasts should be collected.
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PMID:Breast motion asymmetry during running. 2535 91

The effect of adaptation on the perception of a reversible figure was examined in the context of the so-called "reverse-bias effect" in which prolonged exposure to an unambiguous version of a bi-stable ambiguous stimulus serves to bias an observer to report the alternative version of the subsequently viewed ambiguous stimulus. Exposure to the unambiguous stimulus presumably selectively adapts and weakens the neural structures underlying that particular interpretation of the ambiguous figure. We extended previous research by examining the dominance durations for the two alternatives of the reversible figure (i.e., how long each alternative was perceived when it was dominant) in addition to the measures of response rate and choice preference used by other researchers. We replicated earlier findings with the previously used measures. Interestingly, adaptation with an unambiguous version of the ambiguous stimulus produced an asymmetrical effect on the dominance durations of the subsequently presented ambiguous stimulus, relative to a no-adaptation control. The dominance durations were lengthened for the perceptual organization that was the opposite of the adaptation stimulus while they were relatively unaffected for the perceptual organization that was the same as the adaptation stimulus. Our findings are consistent with the argument that adaptation effects play an important role in perceptual bistability. The asymmetrical dominance-duration findings further suggest that adaptation operates in a perceptual system in which the alternative perceptual representations of an ambiguous figure reciprocally inhibit one another via cross-inhibitory processes, consistent with views developed in other forms of bistable perception (e.g., binocular rivalry).
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PMID:Time for a change: what dominance durations reveal about adaptation effects in the perception of a bi-stable reversible figure. 2552 30

This study investigated whether language control during language production in bilinguals generalizes across modalities, and to what extent the language control system is shaped by competition for the same articulators. Using a cued language-switching paradigm, we investigated whether switch costs are observed when hearing signers switch between a spoken and a signed language. The results showed an asymmetrical switch cost for bimodal bilinguals on reaction time (RT) and accuracy, with larger costs for the (dominant) spoken language. Our findings suggest important similarities in the mechanisms underlying language selection in bimodal bilinguals and unimodal bilinguals, with competition occurring at multiple levels other than phonology. (PsycINFO Database Record
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PMID:Language switching across modalities: Evidence from bimodal bilinguals. 2833 6