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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The early results with the PCA total hip replacement have been most gratifying, especially the absence of complications related to the acetabular component. The radiographic evaluation was done critically, and the finding of no progressive acetabular radiolucencies was unexpected. Longer-term evaluation of these interfaces is necessary, but the short-term results have been encouraging. No components have migrated despite the absence of adjunct fixation mechanisms such as screws and flanges. The pressfit achieved with the roughened hemispherical surface has been adequate, and the fixation with the two outrigger pegs appears to have been sufficiently stable to preserve the prosthetic stability and has resulted in successful anchorage of all the components. The results with femoral components are obviously related to technique. In a few early cases when undersized prostheses were used, loosening occurred, and four of these components advanced to detectable loosening. One of these components was revised since this analysis. Attention to detail with maximal filling of the proximal femur apparently led to improved results, with successful anchorage in all subsequent implantations. The application of the dimensional analysis before surgery may indicate those cases in which a tight fitting metaphysis cannot be achieved. In elderly patients who have osteoporotic bone, a substantial mismatch exists between the size of the metaphysis and the diaphysis, and it may be advisable to continue with cement in these cases. By applying the dimensional analysis to preoperative templating, the surgeon may be sufficiently informed to know that a tight fit can be achieved at surgery. No catastrophic failures have occurred. If loosening does occur because of undersizing of the prosthesis, the process appears to be gradual and, although associated with pain, does not result in sudden failure. Despite the prosthesis not being anchored by cement or collar, no sudden subsidence of the components has resulted. Patients' clinical performance has been somewhat slower when compared to cemented series. Performance seems to accelerate once weight bearing occurs, however, and after 2 years no difference exists between this series and a corresponding cemented series. Noncemented total hip arthroplasty appears to offer as good if not better results than cemented total hip arthroplasty, if performed correctly and in the appropriate patient. Successful outcome depends greatly on technique, but when technically adequate implantation has been performed, the results have been gratifying.(ABSTRACT TRUNCATED AT 400 WORDS)
Hip 1987
PMID:Two-year follow-up of the PCA noncemented total hip replacement. 310 5

Between 1987 and 1992, 135 hybrid total hip replacements (THR) were performed in 124 patients. 106 patients, mean age 63 (52-77) years with 113 hips were followed for a an average of 6 (5-10) years. Porous coated PCA cups with 2 pegs were used in 21 cases, the Universal porous coated PCA in 62 and the Kirschner integrity cup in 30. Anatomic PCA stems were used in 83 cases and Kirschner dimension PC stems in 30. The preoperative Harris Hip Score (HHS) was 47. At follow-up, patients were evaluated clinically and radiographically. The position of the acetabular and femoral components were measured and the condition of the cement mantle and the bonecement interface were determined. Postoperatively, the mean HHS was 89. 92% of the patients were symptom free. 3 THR were revised; 2 due to acetabular component loosening and 1 due to failure of the femoral component. The remaining cases were considered stable, although 3 cups were suspected of future loosening.
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PMID:Hybrid total hip replacement. A 5-10-year follow-up study of 106 patients. 938 59

Between 1986 and 1991, 65 cementless hemispherical acetabular cups were implanted in 60 patients in revision surgery. Different designs were used, including PCA (29 cups), Duraloc (14 cups), Harris-Galante (12 cups), and Omnifit (10 cups). The mean age of patients was 54.7 years. The Paprosky types of the acetabular tone defects were type 1, 2 hips; type 2, 38 hips; type 3A, 15 hips; and type 3B, 10 hips. For unrevised hips, the mean follow-up was 8.3 years (range, 6-11 years). Bone allografts were used in 56 hips: Morcellized cancellous graft was used in 42 hips, structural graft for contained defects was used in 7 hips, and structural graft for uncontained defects was used in 7 hips. There were poor clinical results in 14 hips (22%). Re-revision was necessary in 7 hips (10.8%). There was definite radiographic loosening in 18 hips and possible loosening in 4 hips. Screw failure occurred in 6 hips, and a radiolucency in 1 or more DeLee-Charnley zones was apparent in 45 hips (69.2%). Moderate or severe graft resorption were found in 4 of the 42 morcellized grafts, in 6 of the 7 structural grafts for uncontained defects, and in all 7 of the 7 structural grafts for contained defects. The best results were obtained in hips with a bone defect of less than 30%. The use of a cementless acetabular cup supplemented with screws is contraindicated in hips with a bone defect greater than 50%. Hip reconstruction using structural bone-graft to stabilize the prosthesis gives the worst results.
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PMID:Porous-coated cementless acetabular cups in revision surgery: a 6- to 11-year follow-up study. 1042 19

A total of 91 PCA total hip arthroplasties were analysed with a mean follow-up of 13.5 years. Thirty-one cups and six stems were revised. If the patients excluded from the follow-up study are included (113 hips), the cumulative probability of having revision of any prosthetic component for any cause was 16.0% (0.1%-31.9%) at 14 years in the "best case" scenario. Thigh pain (17 hips) was correlated with unstable fixation. Radiographic loosening occurred in 21 cups and 12 stems. Cup loosening was related to acetabular polyethylene wear equal to or more than 2mm per year and also to cup size and thereby polyethylene thickness. Stem loosening was related to poor femoral canal filling. Fifty hips had femoral osteolysis which was related to polyethylene wear of more than 2 mm, poor femoral filling and unstable fixation. (Hip International 2005; 15: 78-84).
Hip Int
PMID:Porous-coated anatomic uncemented total hip arthroplasty. A 10-17-year follow-up. 2822 72