Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pattern of left- and right-side hip injuries to front-seat occupants involved in offset and angled frontal crashes suggests that hip posture (i.e., the orientation of the femur relative to the pelvis) affects the fracture/dislocation tolerance of the hip joint to forces transmitted along the femur during knee-to-knee-bolster loading in frontal impacts. To investigate this hypothesis, dynamic hip tolerance tests were conducted on the left and right hips of 22 unembalmed cadavers. In these tests, the knee was dynamically loaded in the direction of the long axis of the femur and the pelvis was fixed to minimize inertial effects. Thirty-five successful hip tolerance tests were conducted. Twenty-five of these tests were performed with the hip oriented in a typical posture for a seated driver, or neutral posture, to provide a baseline measure of hip tolerance. The effects of hip posture on hip tolerance were quantified using a paired-comparison experimental design. In six pairs of tests, one side of each cadaver was tested with the hip joint oriented in the neutral posture and the contralateral hip from the same cadaver was tested with the hip joint adducted 10 degrees from the neutral posture. In four pairs of tests, the hip was tested in neutral and 30 degrees flexed postures. The average fracture tolerance of the hip in the neutral posture was 6.1-/+1.5 kN. Hip tolerance decreased by an average of 34-/+4% with 30 degrees of flexion from the neutral posture (p<0.0001) and by 18-/+8% with 10 degrees of adduction from the neutral posture (p=0.008).
Stapp Car Crash J 2003 Oct
PMID:Effects of hip posture on the frontal impact tolerance of the human hip joint. 1709 42

An evaluation of the four injury risk curves proposed in the NHTSA NCAP for estimating the risk of AIS>= 3 injuries to the head, neck, chest and AIS>=2 injury to the Knee-Thigh-Hip (KTH) complex has been conducted. The predicted injury risk to the four body regions based on driver dummy responses in over 300 frontal NCAP tests were compared against those to drivers involved in real-world crashes of similar severity as represented in the NASS. The results of the study show that the predicted injury risks to the head and chest were slightly below those in NASS, and the predicted risk for the knee-thigh-hip complex was substantially below that observed in the NASS. The predicted risk for the neck by the Nij curve was greater than the observed risk in NASS by an order of magnitude due to the Nij risk curve predicting a non-zero risk when Nij = 0. An alternative and published Nte risk curve produced a risk estimate consistent with the NASS estimate of neck injury. Similarly, an alternative and published chest injury risk curve produced a risk estimate that was within the bounds of the NASS estimates. No published risk curve for femur compressive load could be found that would give risk estimates consistent with the range of the NASS estimates. Additional work on developing a femur compressive load risk curve is recommended.
Stapp Car Crash J 2010 Nov
PMID:Evaluation of the field relevance of several injury risk functions. 2151 3