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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recent evidence indicates that the transactivation of estrogen receptor alpha (ERalpha) requires estrogen-dependent receptor ubiquitination and degradation. Here we show that estrogen-unbound (unliganded) ERalpha is also ubiquitinated and degraded through a ubiquitin-proteasome pathway. To investigate this ubiquitin-proteasome pathway, we purified the ubiquitin ligase complex for unliganded ERalpha and identified a protein complex containing the carboxyl terminus of Hsc70-interacting protein (CHIP). CHIP preferentially bound to misfolded ERalpha and ubiquitinated it to induce degradation. Ligand binding to the receptor induced the dissociation of CHIP from ERalpha. In CHIP-/- cells, the degradation of unliganded ERalpha was abrogated; however, estrogen-induced degradation was observed to the same extent as in CHIP+/+ cells. Our findings suggest that ERalpha is regulated by two independent ubiquitin-proteasome pathways, which are switched by ligand binding to ERalpha. One pathway is necessary for the transactivation of the receptor and the other is involved in the quality control of the receptor.
EMBO J 2004 Dec 08
PMID:Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor. 1553 84

Invasive cardiologists generally consider radiation to be the chief occupational hazard. Heavy leaded aprons worn to reduce this risk may be associated with orthopedic complications. This study was designed to characterize the prevalence of these occupational health problems. The Interventional Committee of the Society for Cardiac Angiography and Interventions (SCAI) sent to its Internet-registered members a Web-based survey. Inquiries included age, years of invasive practice, and diagnostic/interventional cases/year. Questions (yes/no) focused on orthopedic (spine, hips, knees, and ankles) and radiation-associated problems (cataracts and cancers). The survey was sent to over 1,600 members with 424 responses. Responders were on average busy and experienced, performing catheterization > 10 years in 62% of cases and > 20 years in 24% others. Average annual diagnostic-only case load was > 200/year in 72%, > 300/year in 43%, and > 500/year in 18% of responders. Reported annual interventional caseload was > 100/year in 83%, > 200/year in 37%, and > 300/year in 15% of operators. Orthopedic problems included spine problems in 42% of responders (of these, 70% were lumbosacral and 30% cervical). Hip, knee, or ankle problems were noted in 28% of operators. Spine problems were related to the annual procedural caseload and the number of years in practice. Over one-third reported spine problems had caused them to miss work. The results of the radiation queries were inconclusive. These results document that interventional cardiologists commonly suffer orthopedic disease, frequently leading to lost work days.
Catheter Cardiovasc Interv 2004 Dec
PMID:Occupational hazards of interventional cardiologists: prevalence of orthopedic health problems in contemporary practice. 1555 65

There have been many publications about second generation femoral nails, such as the Russell-Taylor nail (Smith & Nephew Richards, Memphis, TN, USA) and Long Gamma Nail (Howmedica, Rutherford, NJ, USA), but little work has been published on the Long Intra-medullary Hip Screw (IMHS, Smith & Nephew). We set out to evaluate the effectiveness of the Long IMHS as a device for the fixation of proximal femoral fractures. We retrospectively reviewed 30 patients who had a Long IMHS inserted for a sub-trochanteric or proximal femoral fracture. Of the 30 patients, three had died and six were lost to follow up, leaving 21, whom we reviewed. Of the 21 patients reviewed the mean age was 67 years and the mean follow up was 31 weeks. Mean time to union was 15.65 weeks, with one non-union. There were three superficial wound infections. In one patient there was loosening of the distal locking screws, requiring removal and there was one case of intra-operative femoral shaft fracture. We conclude that, the Long IMHS is an effective device for the treatment of sub-trochanteric and proximal femoral fractures with a high rate of union achieved and a low complication rate.
Injury 2004 Dec
PMID:Evaluation of the long intra-medullary hip screw. 1556 Nov 16

Hip instability remains a costly complication of primary (3%) and revision (10%) procedures. In those with well-oriented components, instability may be anticipated in about 70% from advancement of the trochanter. Articular reorientation readily is affected by the use of modular cups with elevated rims. This has proven to be an effective strategy both to lessen the likelihood of an initial dislocation after both primary and revision procedures. It has also proven to be an effective strategy to treat the unstable implant, especially if cup orientation has been defined as the primary problem. Larger head sizes in the range of low-friction arthroplasty, such as 32 mm, are not any more stable than 22-mm diameter implants. Anatomic-sized heads as used in bipolar devices are effective in treating established instability in up to 90% of instances. The most popular current option is that of the constrained head/cup articulation. Good short-term results have revealed success in more than 90%. However, the effectiveness is design dependent, and the long-term effectiveness understandably is questioned as reports of mechanical failure begin to emerge.
Clin Orthop Relat Res 2004 Dec
PMID:Results of reoperation for hip dislocation: the big picture. 1557 72

Recently there has been increased interest in doing total hip replacement through small incisions. One such technique is the two-incision approach. After initial investigations into its feasibility, Zimmer developed a training program for surgeons interested in doing the so called MIS 2-Incision Hip Procedure. An "index case" study was initiated to track the early experiences of trained surgeons, which includes 159 surgeons who have completed such training and recorded data on their initial cases. The purpose of this report is to present the data available from this index case study regarding the process of developing proficiency with the two-incision total hip replacement. We found a significant decrease in the mean operative time and fluoroscopy time from the first to tenth case. Key complications did not show a systematic decrease as a function of case number for the first ten cases. Clarification of the entire learning curve for this technique requires further investigation but may last beyond case ten for many surgeons. In addition, data from this study suggests that patient characteristics and surgeon experience have a significant effect on the prevalence of complications with the two-incision technique. The evolution of minimally invasive joint replacement is clearly in its infancy. Complication rates and the demonstrated learning curve may be altered by changes in training and surgical techniques.
Clin Orthop Relat Res 2004 Dec
PMID:Learning curve for the two-incision total hip replacement. 1557 93

Eighty-four hips with Ficat stage III and IV osteonecrosis were treated: 56 with metal-on-metal surface arthroplasty (MMSA) and 28 with hemi-surface arthroplasty (HSA). Average follow-up was 4.9 years. UCLA hip scores were significantly better for MMSA versus HSA for function and activity as well as Harris Hip scores and physical component of the SF-12 scores. In the MMSA group, 2 hips were revised to total hip arthroplasty for femoral loosening, and 5 hips had adverse radiological changes. In the HSA group, 4 hips were revised (1 sepsis and 3 for pain). There was no evidence of any femoral loosening or neck narrowing in the HSA group. Although the functional clinical outcome of MMSA is superior to HSA, long-term follow up of MMSA will determine the reliability of the femoral fixation.
J Arthroplasty 2004 Dec
PMID:Surface arthroplasty for osteonecrosis of the hip: hemiresurfacing versus metal-on-metal hybrid resurfacing. 1557 54

A pilot cohort study of 60 primary total hip arthroplasties (THAs) was undertaken to evaluate the technical aspects and possible clinical advantages of performing THA through a single-incision, minimally invasive, 10-cm-length, direct lateral approach compared with the same approach performed through a standard-length skin incision. We could not show any significant difference with regard to operative time; in-hospital equianalgesic opioid consumption; postoperative blood loss; complications; hospital length of stay; or flexion, Harris Hip and Oxford Scores at 6 weeks' postoperatively. Restricting the length of skin incision for THA performed through a direct lateral approach does not appear to afford any clinical advantage to the patient in the short term. The mini-exposure creates technical challenges that have the potential to adversely affect primary THA outcome.
J Arthroplasty 2004 Dec
PMID:Single-incision, minimally invasive total hip arthroplasty: length doesn't matter. 1558 28

To evaluate different modes of cementless fixation of hemispherical cups, we operated on 87 hips in 81 patients using 4 different means of cup fixation. The hips were randomly assigned to fixation with press-fit technique only (PF), or with augmentation with screws (S), pegs (P), or hydroxyapatite (HA) coating. The patients were evaluated with radiostereometric analysis (RSA) for cup migration and wear, conventional radiography for osteolysis, and Harris Hip Score for clinical outcome over 5 years. The fixation of the cups did not differ between the groups, but HA showed a tendency to decrease proximal migration. HA-coated cups displayed the best interface with hardly any signs of radiolucent lines, indicating a superior sealing effect of the HA coating. Cups with screws or pegs had more radiolucent lines and osteolytic lesions than the other groups. Radiolucent lines were correlated to higher proximal migration, young age, and female gender (r2=.2). The wear rate of the ethylene oxide-sterilized polyethylene liner was high (0.2 mm/y) but did not differ between the groups. Two cups with a perioperative fracture of the acetabular rim showed large initial migration but stabilized thereafter.
J Arthroplasty 2004 Dec
PMID:Effect of augmented cup fixation on stability, wear, and osteolysis: a 5-year follow-up of total hip arthroplasty with RSA. 1558 31

A unique, straight-stemmed, proximally porous-coated, modular hip arthroplasty system, coated with thin-film (5- to 9-microm), titanium-nitride ceramic, was used clinically in 130 hip arthroplasties in 117 patients who were followed over a 2- to 12-year interval (mean, 6.45 years). Harris Hip Scores demonstrated 82.3% excellent, 15.4% good, 2.3% fair, and 0% poor results. Thigh pain that limited activities of daily living was seen in 0.8% (1 of 130) hips. Kaplan-Meier survival estimates using an endpoint of revision of any component for any reason demonstrated an overall survival of 95.5% during the 12-year interval. Cementless fixation survivorship of the acetabular and femoral components was 98.5% during the 12-year interval.
J Arthroplasty 2004 Dec
PMID:Two- to 12-year evaluation of cementless Buechel-Pappas total hip arthroplasty. 1558 38

The aim of the study was to assess the change in function and residential status four months after hip fracture in patients over 50 years of age and living independently at home at the time of fracture. All consecutive hip fracture patients treated at Oulu University Hospital during 1989--1999 were followed up. Data collection was done on standardized hip fracture forms, which were filled in at admission and at four months postoperatively. The forms included demographic data, place of residence, locomotor ability, use of walking aids, data on the fracture and its treatment, hospital stay, place of discharge and pain. At four months, 16.0% of the men and 14.3% of the women were permanently institutionalized. Preoperatively, 81.1% of the patients had been able to walk out of doors either alone or accompanied, while at 4 months, less than half of the patients (149 men, 391 women) were able to do so. Two thirds of the hip fracture patients had been able to walk without walking aids before the fracture, the corresponding proportion being one fifth at four months after the fracture. Cumulative mortality at 4 months was 9.9%, being higher among the male (15.5%, n=53) than the female patients (7.9%, n=75). The original study population was also divided into two subgroups operated at different period of time (1989--92 and 1993--99), the functional results seemed to improve with time. Hip fracture leads to the institutionalization of every seventh patient able to live at home at the time of fracture and impairs markedly one's functional capacity. To restore the pre-fracture status as well as possible and to reduce the burden of the consequences of hip fracture, it might be beneficial to evaluate and improve the existing rehabilitation system.
Cent Eur J Public Health 2004 Dec
PMID:Functional ability after hip fracture among patients home-dwelling at the time of fracture. 1566 60


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