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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The emu, a large bipedal bird with hip joint biomechanics similar to humans, was used to establish an experimental model of femoral head osteonecrosis and subsequent femoral head collapse. Focal lesions were induced in 20 adult male emus using an alternating liquid nitrogen freezing and radiofrequency heating insult. At 2, 4, 8, 12 and 16 weeks post-surgery, hip magnetic resonance imaging (MRI) was performed. Before the emus were sacrificed, barium sulphate was infused to the lower extremity to study blood vessel distribution patterns. Femoral samples were scanned by micro-computed tomography (micro-CT) and evaluated histologically. Hip MRI showed changes from broad oedema to femoral head collapse. Emus developed a crippled gait from post-operative week 6. Micro-CT scans and histology showed human-like osteonecrotic changes with an impaired local blood supply. The protocol resulted in consistent full-range osteonecrosis of the femoral head that may serve as a model for testing potential treatments.
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PMID:Emu model of full-range femoral head osteonecrosis induced focally by an alternating freezing and heating insult. 2167 21

While not proven definitively, the hypothesis that intra-articular psoas tendon release allows fluid to track into the retroperitoneal space has been widely accepted. This study attempts to identify the path through which fluid enters the pelvis and retroperitoneal space. Six hemi-pelvis human cadaveric specimens were utilized for this study. 3 specimens underwent a capsulotomy and psoas tendon release, while 3 had only a capsulotomy. Arthroscopy fluid was combined with Barium and Methylene blue, and fluid was run at 50 mmHg for 2 hours. A gross dissection was performed at the end of the arthroscopy and the path of fluid flow into the pelvis and throughout the thigh was identified. All 6 specimens showed extravasation of fluid into the pelvis at the 5 minute mark. Specimens with a psoas tendon release showed an altered pattern of fluid flow. In all three of these specimens, the psoas muscle belly was bright blue, along with the remaining tendon. Two of the 3 specimens showed tracking of fluid along the vasculature in both directions. The volume of fluid tracking into the pelvis was increased following a psoas release. Arthroscopy fluid rapidly enters the pelvis following the initiation of hip arthroscopy, regardless of the status of the psoas tendon. Release of the psoas tendon allows fluid to diffuse into the psoas muscle and anterior medial thigh, tracking both proximally and distally along the neurovascular structures, and the volume of fluid tracking into the pelvis is increased following a psoas release.
Hip Int
PMID:Intra-articular psoas tendon release alters fluid flow during hip arthroscopy. 2323 81