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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The efficacy of using hydroxyapatite/tricalcium phosphate (HAP/TCP) particles to enhance the biological fixation of a canine cementless femoral component with a noninterference fit was evaluated with a custom-designed collarless, wedge-shaped femoral component with titanium fiber metal pads along the anteroposterior surfaces of the stem. A polyethylene acetabular component was cemented into the pelvis. Three groups of dogs were employed: group I (n = 7) had a femoral component with an interference fit; group II (n = 6) had a component with a noninterference fit with uniform voids along the anteroposterior stem surfaces; and group III (n = 6) had a component with a noninterference fit including uniform voids filled with HAP/TCP particles. All dogs were harvested after 12 weeks of unrestricted weight bearing. Cross-section specimens from three different levels from each bone-component composite were evaluated histologically to determine the type and extent of tissue ingrowth and the percentage of peripheral bone or HAP/TCP particles adjacent to the fiber metal pad surfaces. Three other cross-section specimens, adjacent to the histological section levels of the same composites, were assessed for shear strength at the fiber metal-tissue interface and for biochemical composition of the ingrown tissue.
Hip 1987
PMID:The John Charnley Award paper. Efficacy of using a bone graft substitute to enhance biological fixation of a porous metal femoral component. 381 46

This study was designed to investigate bone remodelling around the cup in cementless THA. Previous studies indicate an advantage of better sealing of the bone-prosthesis interface by HA/TCP coating of implants, inhibiting polyethylene-induced osteolysis. One hundred patients gave informed consent to participate in a controlled randomized study between porous coated Trilogy versus Trilogy Calcicoat (HA/TCP coated). The cup was inserted in press-fit fixation. The femoral component was a cementless porous coated titanium alloy stem (Bi-Metric), with a modular 28-mm CrCo head. The Harris Hip Score (HHS) and bone mineral density (BMD) determined by DEXA scanning were used to study the effect. Measurements revealed no difference between the two groups after 3 years either in the clinical outcome or in terms of periprosthetic bone density. Patients with a body mass index above normal regained more bone mineral than patients with normal weight. This finding supports the assumption that load is beneficial to bone remodelling.
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PMID:Bone remodelling around HA-coated acetabular cups : a DEXA study with a 3-year follow-up in a randomised trial. 1676 Nov 53