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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In Central Finland, the age-specific incidence of hip fractures did not change between the years 1982-1983 and 1992-1993 though the total number of hip fractures increased by 11% due to population aging. The objective of this study was to define the current hip fracture rates and the characteristics of patients with hip fracture. The population at risk consisted of 240,000 persons living in the Central Finland Health Care District. Hip fracture patients were identified by using the hospital discharge register, the operation lists, and the register of the Department of Anesthesiology. Patients' residential status, weight, and height, date and time of hip fracture, place of accident and mechanism and type of fracture were obtained from medical records. A total of 597 patients, 415 (69.5%) women and 182 (30.5%) men, were admitted to the hospital for treatment of an acute hip fracture in 2002-2003. The mean age of the patients was 79 (SD 13) years. Among patients aged > or =50 years (n = 577), 80.8% of the hip fractures had occurred indoors, 97.6% with a low-energetic mechanism, and 22.7% during the nighttime. The ratio of trochanteric to cervical fractures was 2:3. Between 1992-1993 and 2002-2003, the total number of hip fractures increased by 70%, from 351 to 597. The fracture rates per 1000 person-years in the age group > or =55 years were 2.0 and 3.9 in 1992-1993 and 2.8 and 5.6 in 2002-2003 for men and women, respectively. The corresponding age-adjusted incidence rate ratio (IRR) for men was 1.36 (95% CI: 1.06 to 1.76), P = 0.017, and for women 1.25 (95% CI: 1.07 to 1.47), P = 0.006. Among men, the IRR was highest in the age group 75-84 years, IRR = 1.67 (95% CI: 1.08 to 2.65), while among women, it was highest in the age group > or =85 years, IRR = 1.33 (95% CI: 1.02 to 1.75). The total number of hip fractures almost doubled within 10 years, and the age-adjusted incidence rate increased in both sexes. The accretion of the hip fracture incidence was more than could be explained merely by changes in population size and structure.
Bone 2006 Sep
PMID:Increased incidence of hip fractures. A population based-study in Finland. 1660 27

In an inception cohort of 196 Olmsted County, Minnesota, residents with Parkinson's disease (PD) first recognized in 1976 to 1995, we tested whether the increased risk of bone fractures is associated with concomitant dementia. Using the data resources of the Rochester Epidemiology Project, information about PD, dementia, other clinical risk factors for fracture and fracture events was obtained from review of complete inpatient and outpatient medical records spanning each subject's residence in the community. Compared to an equal number of age- and sex-matched non-PD referent subjects from the community, PD patients were at a 2.2-fold increased risk of fractures generally and a 3.2-fold greater risk of hip fractures specifically. Adjusting for age, the independent predictors of overall fracture risk in the PD subjects included female sex (hazard ratio [HR] 1.6; 95% confidence interval [CI], 1.1-2.3), dementia (HR, 1.6; 95% CI, 1.1-2.4) and chronic depression, which was associated with a reduced risk (HR, 0.4; 95% CI, 0.2-0.8). Hip fractures were predicted by dementia (HR, 2.2; 95% CI, 1.2-4.1). The increased fracture risk in patients with PD is not entirely explained by concomitant dementia, and additional study is needed to determine the relative contributions to fracture risk of falls versus bone loss in these patients.
Mov Disord 2006 Sep
PMID:Fracture risk after the diagnosis of Parkinson's disease: Influence of concomitant dementia. 1670 87

The risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) is well documented in patients following cast immobilisation for injuries of lower extremities. There are no generally accepted approaches to preventing this complication and hence there remains substantial practice variation amongst surgeons regarding the use of anticoagulation measures. The present survey was conducted to investigate the current chemothromboprophylaxis practice among UK orthopaedic departments for patients immobilised with plasters for lower extremity injuries and establish any variations in practice. A telephone questionnaire survey was conducted on junior doctors (Senior House Officers and Registrars) in orthopaedic departments of 70 randomly selected hospitals in United Kingdom. This survey assessed the thromboprophylaxis practice for lower limb injuries in plaster casts. Our results show substantial variation amongst British orthopaedic surgeons in the use of chemothromboprophylaxis measures. Sixty-two percent of the departments do not use any DVT prophylaxis in this group of trauma. Furthermore, only 11.4% of the departments performed risk stratification on their patients. Ninety-nine percent of the respondents were unaware of any existing guidelines in this regard. Although the incidence of DVT in patients in plaster for lower extremity injuries is low compared to the Hip/Knee arthroplasty group, this is not insignificant. Both over and under treatment with thromboprophylaxis can have implications in terms of side effects and costs. One possible solution is to use risk stratification to identify individuals who are likely to benefit from prophylaxis. There is a substantial variation and inconsistency in practice among orthopaedic departments in United Kingdom due to a lack of clinical guidelines in this group of trauma and it remains underused even in high-risk group.
Injury 2006 Sep
PMID:Thromboprophylaxis following cast immobilisation for lower limb injuries--survey of current practice in United Kingdom. 1676 68

The convenience of the motor-driven treadmill makes it an attractive instrument for investigating rat locomotion. However, no data are available to indicate whether hindlimb treadmill kinematic findings may be compared or generalized to overground locomotion. In this investigation, we compared overground and treadmill locomotion for differences in the two-dimensional angular kinematics and temporal and spatial measurements for the hindlimb. Ten female rats were evaluated at the same speed for natural overground and treadmill walking. The walking velocity, swing duration and stride length were statistically indistinguishable between the two testing conditions. Significant differences were found between overground and treadmill locomotion for step cycle duration and stance phase duration parameters. During the stance phase of walking, the angular movement of the hip, knee and ankle joints were significantly different in the two conditions, with greater flexion occurring on the overground. Despite this, the sagittal joint movements of the hindlimb were similar between the two walking conditions, with only three parameters being significantly different in the swing. Hip height and angle-angle cyclograms were also only found to display subtle differences. This study suggests that reliable kinematic measurements can be obtained from the treadmill gait analysis in rats.
Behav Brain Res 2006 Sep 25
PMID:A comparison analysis of hindlimb kinematics during overground and treadmill locomotion in rats. 1677 43

Less-invasive techniques for total hip arthroplasty (THA) have sparked an increased interest among orthopedic surgeons and patients. There has been concern regarding decreased surgical exposure and compromise in prosthesis durability. We present the first long-term outcome of THA performed via the mini-incision posterior approach to show the durability of implant fixation. We compare the clinical and radiographic findings with previously published findings of authors using the same femoral implant and standard surgical techniques over a similar follow-up period. Ninety implants were followed for 10 to 13 years. Clinical evaluation revealed a Harris Hip Score of 92.3. Radiographic evaluation revealed proximal bone atrophy in 57% and lucent lines in 14% of femurs and 11% of cups. Osteolysis was noted in 10% and was associated with polyethylene wear. There were no cases of aseptic stem loosening. Eight polyethylene inserts were revised for wear. These 10-year minimum follow-up findings are consistently comparable with previously published studies using the same implant and larger surgical approaches followed for a similar period. Mini-incision THA technique did not compromise the long-term clinical and radiographic findings when compared with conventional techniques.
J Arthroplasty 2006 Sep
PMID:Durability of implant fixation after less-invasive total hip arthroplasty. 1695 27

The Fitmore titanium mesh cementless acetabular component in 115 hip arthroplasties was reviewed at an average of 33 months of follow-up. None were revised nor had infection. One hip dislocated 4 years postoperatively. Two femoral components were revised. The average Harris Hip Score at the last follow-up was 90 points. In the 96 sets of radiographs available, there was no loosening or new radiolucency. One hip had nonprogressive osteolysis adjacent to a screw. This press-fit cup has its polar region flattened and is rim loading. Noncontact (gaps) at the acetabular floor is expected and is not critical for fixation. In all but 6 hips, these gaps filled. In 5 hips, a minimal gap (<or=0.5 mm) remained in part of the equatorial region. The Fitmore cup osseointegrates successfully.
J Arthroplasty 2006 Sep
PMID:Early clinical and radiographic analysis of the Fitmore cup. 1695 37

National orthopedic subspecialty meetings are a research forum where volumes of investigations are presented after a peer-reviewed selection process. The objective of this investigation was to determine the publication rate of recent scientific presentations presented at the American Association of Hip and Knee Surgeons (AAHKS) annual meetings. From 1996 to 2001, 168 (58%) of 292 podium abstracts presented at meetings were published. The average time to publication was 21.7 +/- 14.7 months. Three major orthopedic journals constituted 89% of the publications. The 58% publication rate for AAHKS ranks as one of the higher rates for orthopedic specialty meetings and validates the selection process for abstracts presented. In addition, AAHKS meetings are an excellent source for a wide array of quality research and scientific information.
J Arthroplasty 2006 Sep
PMID:Publication rates of scientific presentations at the American Association of Hip and Knee Surgeons annual meetings from 1996 to 2001. 1695 54

In recent years, there has been an increasing debate regarding the possible role of minimally invasive (MIS) total hip arthroplasty (THA). We conducted a questionnaire survey of the Hip Society members and compared the responses of the surgeons with those of patients who were being considered for THA. 80% of surgeons who completed the survey admitted to performing MIS THA, of whom two thirds defined MIS as small incision. Of surgeons, 74% had encountered some complication related to MIS THA; 67% of patients had not heard of MIS THA. The knowledge regarding MIS THA expressed by 80% of patients was either inaccurate or not substantiated by any studies. This survey highlights the inadequacy of our current understanding of MIS THA and lack of education on the part of the patients.
J Arthroplasty 2006 Sep
PMID:Hip arthroplasty with minimally invasive surgery: a survey comparing the opinion of highly qualified experts vs patients. 1695 60

Hip fractures are a major cause of disability, impairment and death in elderly people. It has been reported that bisphosphonates significantly reduce the risk of hip fracture among elderly women with confirmed osteoporosis but not among elderly women selected primarily on the basis of risk factors other than low bone mineral density. External hip protectors have been developed as a measure of reducing the impact of the fall and thereby the chance of hip fractures in such high risk people. The results of 14 randomized controlled trials for the prevention of hip fractures by using hip protectors have been reported until 2004. However, Cochrane review of hip protectors has concluded that their effectiveness is uncertain. Although further research is required with different conditions, the most important issue of hip protectors is the low adherence rate.
Clin Calcium 2006 Sep
PMID:[Progress in external hip protectors]. 1695 74

A computer-aided classification system was developed for the assessment of the severity of hip osteoarthritis (OA). Sixty-four radiographic images of normal and osteoarthritic hips were digitized and enhanced. Employing the Kellgren and Lawrence scale, the hips were grouped by three experienced orthopaedists into three OA-severity categories: Normal, Mild/Moderate and Severe. Utilizing custom-developed software, 64 ROIs corresponding to the radiographic Hip Joint Spaces were manually segmented and novel textural features were generated. These features were used in the design of a two-level classification scheme for characterizing hips as normal or osteoarthritic (1st level) and as of Mild/Moderate or Severe OA (2nd level). At each classification level, an ensemble of three classifiers was implemented. The proposed classification scheme discriminated correctly all normal hips from osteoarthritic hips (100% accuracy), while the discrimination accuracy between Mild/Moderate and Severe osteoarthritic hips was 95.7%. The proposed system could be used as a diagnosis decision-supporting tool.
Med Biol Eng Comput 2006 Sep
PMID:Osteoarthritis severity of the hip by computer-aided grading of radiographic images. 1696 Jul 46


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