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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied the long-term outcome of uncemented total hip arthroplasty using HG-I components in 90 hips (80 patients) with an average age of 57.5 years who were operated on between 1984 and 1986 at our institution. Average follow-up was 14.9 years, and no patient was lost to follow-up. Hip scores improved significantly, and there was clinical and radiographic evidence of bony ingrowth on the acetabular components in all patients. There were 11 revisions in the study population for reasons related to failure of the femoral component (8 hips), acetabular liner dissociation (2 hips), and deep infection (1 hip). At the latest follow-up, 3 femoral components were determined to be loose. No acetabular component was revised for aseptic loosening. In addition to the revisions, there were 2 reoperations, 1 for psoas tendon release, and 1 for excision of heterotopic ossification. Thus, the survivorship free of revision and free of mechanical failure for the acetabular component at 15 years was 95.7% (95% confidence interval [CI], 0.89-1.0) and 91.9% (95% CI, 0.83-0.98), respectively. The survivorship at 15 years for the femoral component was 86.8% (95% CI, 0.78-0.95) free of revision and 82.0% (95% CI, 0.71-0.92) free of mechanical failure.
J Arthroplasty 2004 Sep
PMID:Fifteen-year clinical survivorship of Harris-Galante total hip arthroplasty. 1534 24

The purpose of this study was to evaluate the hypothesis that the mechanical failure rate is reduced by the combined use of cortical strut and impacted cancellous allografts. There were 10 men and 14 women in the series, with a mean age at the time of the index revision of 56.6 years (range, 43-69 years). They were followed up for a minimum of 5 years (mean, 5.8 years; range, 5-7 years). The Harris Hip Score improved from a mean of 26 points (range, 10-37 points) before revision surgery to a mean of 83 points (range, 45-100 points) at the latest review. The mean visual analogue scale to pain was 8.4 (4-10), and the mean satisfaction visual analogue scale was 8.7 (4-10). WOMAC scores at the latest review correspond to mild pain, mild stiffness, and only moderate difficulty with physical activity. One femoral stem (4%) had aseptic loosening, and it was revised. Two hips (8%) had infection. All allografts were incorporated to the host femur. The combination of proximal onlay strut grafts with impaction bone grafting in femora with proximal segmental bone defects is associated with very acceptable results at midterm follow-up.
J Arthroplasty 2004 Sep
PMID:Cemented revision hip arthroplasty using strut and impacted cancellous allografts. 1534 32

In December 2000, Sulzer Orthopedics Inc. announced the recall of specific lots of Inter-Op acetabular components as a result of an adverse tissue response to a contaminant on the porous surface of the component. This study was initiated to assess bone viability surrounding the primary and revision components. Twelve patients were placed on a double-tetracycline labeling protocol before revision surgery. Initial and final acetabular reamings were frozen-sectioned using cryostat technology. A mineral apposition rate, preoperative and postoperative radiographs, and Harris Hip Scores were evaluated. The tetracycline data showed that bone viability was not compromised at initial or final reaming levels in this series of patients. Significant improvement was observed in postoperative Harris Hip Scores when compared with preoperative Harris Hip Scores.
J Arthroplasty 2004 Sep
PMID:Bone viability determination in human cancellous bone from patients undergoing revision hip arthroplasty. 1534 35

An obstacle contacting the dorsal surface of a cat's hind foot during the swing phase of locomotion evokes a reflex (the stumbling corrective reaction) that lifts the foot and extends the ankle to avoid falling. We show that the same sequence of ipsilateral hindlimb motoneuron activity can be evoked in decerebrate cats during fictive locomotion. As recorded in the peripheral nerves, twice threshold intensity stimulation of the cutaneous superficial peroneal (SP) nerve during the flexion phase produced a very brief excitation of ankle flexors (e.g., tibialis anterior and peroneus longus) that was followed by an inhibition for the duration of the stimulus train (10-25 shocks, 200 Hz). Extensor digitorum longus was always, and hip flexor (sartorius) activity was sometimes, inhibited during SP stimulation. At the same time, knee flexor and the normally quiescent ankle extensor motoneurons were recruited (mean latencies 4 and 16 ms) with SP stimulation during fictive stumbling correction. After the stimulus train, ankle extensor activity fell silent, and there was an excitation of hip, knee, and ankle flexors. The ongoing flexion phase was often prolonged. Hip extensors were also recruited in some fictive stumbling trials. Only the SP nerve was effective in evoking stumbling correction. Delivered during extension, SP stimulus trains increased ongoing extensor motoneuron activity as well as increasing ipsilateral hip, knee, and ankle hindlimb flexor activity in the subsequent step cycle. The fictive stumbling corrective reflex seems functionally similar to that evoked in intact, awake animals and involves a fixed pattern of short-latency reflexes as well as actions evoked through the lumbar circuitry responsible for the generation of rhythmic alternating locomotion.
J Neurophysiol 2005 Sep
PMID:Stumbling corrective reaction during fictive locomotion in the cat. 1591 25

In men, osteoporosis is a prevalent problem that is under-recognized and undertreated. Men 50 years and older have a 13% lifetime risk for fracture. Hip and vertebral fractures are associated with significant functional impairment and increased mortality in men. The morbidity and mortality following a fracture is also greater in men than it is in women. By improving our knowledge on the pathophysiology of osteoporosis in men, better management strategies for this condition may be developed. In recent years, there has been greater awareness of the biomechanic factors that contribute to bone strength, which may explain some of the differences in fracture incidence between men and women. There is also growing evidence to support the key role of estrogens in maintaining bone health in older men, similar to women. This review highlights our current understandings on the epidemiology and pathophysiology of male osteoporosis and its related fractures, with particular focus on the determinants of bone strength and the role of sex hormones on bone metabolism in men.
Curr Osteoporos Rep 2003 Sep
PMID:Male osteoporosis: epidemiology and pathophysiology. 1603 68

Hip fracture is an important public health and personal burden, and this burden is anticipated to increase over the next several decades. Although white women experience the greatest lifetime risk of hip fracture, risk extends to men and to nonwhite populations. Bone strength, risk of falling, and individual clinical characteristics combine to affect the risk of hip fracture. Nearly $9 billion were expended in 1995 in the United States for the management of hip fractures. Hip fracture has important sequelae, including loss of bone and muscle mass. Mortality is significantly increased after hip fracture, and functional recovery is limited to less than 50% of those who fracture. About 25% of patients reside in long-term care facilities for a year or more after fracture, and the impact of hip fracture on health-related quality of life is considerable and long lasting.
Curr Osteoporos Rep 2003 Sep
PMID:Hip fracture: risk factors and outcomes. 1603 69

To gain insight into the coordination of gene expression profiles during forelimb and hindlimb differentiation, a transcriptome analysis of mouse embryonic autopod tissues was performed using Affymetrix Murine Gene Chips (MOE-430). Forty-four transcripts with expression differences higher than 2-fold (T test, P < or = 0.05) were detected between forelimb and hindlimb tissues including 38 new transcripts such as Rdh10, Frzb, Tbx18, and Hip that exhibit differential limb expression. A comparison of gene expression profiles in the forelimb, hindlimb, and brain revealed 24 limb-signature genes whose expression was significantly enriched in limb autopod versus brain tissue (fold change >2, P < or = 0.05). Interestingly, the genes exhibiting enrichment in the developing autopod also segregated into significant fore- and hindlimb-specific clusters (P < or = 0.05) suggesting that by E 12.5, unique gene combinations are being used during the differentiation of each autopod type.
Dev Dyn 2005 Sep
PMID:Transcriptome analysis of the murine forelimb and hindlimb autopod. 1605 10

This cross-sectional study was designed to investigate correlations between muscle strength and regional bone mineral density (BMD) in sedentary postmenopausal women. Sixty-two women who ranged in age from 41 to 76 years were investigated. Hip and trunk muscle strength was measured by isokinetic dynamometry. Grip strength of the nondominant hand was measured using a hand-held dynamometer. Bone mineral density of the lumbar spine, femur, and distal radius was measured by dual-energy X-ray absorptiometry. Only the correlation between hip abductor strength and femoral BMD was significant (P = 0.009, r = 0.327). There was no correlation between trunk muscle strength and lumbar vertebral BMD or between grip strength and distal radius BMD. Subjects with osteoporosis (T score < -2.5) or osteopenia T (-2.5 to -1) and normal subjects (T > -1) exhibited similar isokinetic hip and trunk muscle strength. Women with osteoporotic distal radii had significantly lower grip strength than subjects who were osteopenic or normal at this site, but the osteoporotic group was also significantly older. In conclusion, our results indicate that the isokinetic strength of hip abductors weakly correlates with femoral BMD in postmenopausal women with and without osteoporosis. Trunk muscle strength did not correlate with lumbar vertebral BMD in either of these groups. The weaker handgrip we observed in the women with osteoporotic radii may be attributed to older age.
Rheumatol Int 2005 Sep
PMID:Relationships between muscle strength and bone mineral density of three body regions in sedentary postmenopausal women. 1616 63

Hip instability continues to be an infrequent, yet frustrating complication of total hip arthroplasty (THA). Restoration of normal hip anatomy and biomechanics at the time ofTHA is critical to reduce the risk of dislocation. This can be difficult in some patients due to distorted hip anatomy and wide variations in "normal" hip anatomy reported in numerous studies. Modular femoral components offer a large array of femoral offset, length, and version options which can be used independently or in combination to recreate normal osseous anatomy and a well-tensioned soft tissue envelope, which should enhance hip stability following THA.
Orthopedics 2005 Sep
PMID:Stability advantages of a modular total hip system. 1619 34

Hip arthroplasty is performed nowadays according to the needs of the patients irrespective of their age. Tapered rectangular stems for cementless fixation are chosen in most cases in central Europe. They provide primary stability by press-fit implantation into a precisely rasped osseous bed and secondary stability by bone ingrowth into the highly biocompatible titanium alloy with a microrough surface. The 10-year survival of such devices is 92%. Typical radiographic patterns include cortical atrophy and radiolucent lines in Gruen zones 1 and 7. They are due to stress shielding with these distally fixed implants. The number one reason for revision is polyethylene wear and subsequent osteolysis. Metal-on-metal and ceramic-on-ceramic bearings show less wear but osteolysis continues to be a problem.
Radiologe 2006 Sep
PMID:[Results of cementless hip arthroplasty]. 1655 11


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