Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

X-ray measurements of the hip joints of children, with special reference to the acetabular index, suggest that the upper standard deviation of normal comprises the borderline to a critical zone where extreme values of normal and pathologic hips were found together. Above the double standard deviation only severe dysplasias were present. Investigations of the shaft-neck angle and the degree of anteversion including the wide standard deviation demonstrate that it is very difficult to determine where these angles become pathologic. It is more important to look for the relationship between femoral head and acetabulum. A new measurement--the Hip Value is based on measurements of the Idelberg- Frank angle, the Wiberg angle and MZ-distance of decentralization. By statistical methods, normal and pathological joints can be separated as follows: in adult Hip Values, between 6 and 15 indicate a normal joint form; values between 16 and 21 indicate a slight deformation and values of 22 and above are indications of a severe deformation, in children in the normal range the Hip Value reaches 14; values of 15 and up are pathological.
Clin Orthop Relat Res 1976 Sep
PMID:Normal values of the hip joint for the evaluation of X-rays in children and adults. 95 21

A vascular necrosis of the femoral head associated with steroid immunosuppression is a cause of significant morbidity in renal transplant recipients. We review the results of 30 total hip replacements in 20 renal transplant recipients with a mean follow-up of 6.3 years. The mean age at the time of surgery was 35 years. The average Hospital for Special Surgery Hip Score was 17 points before operation and 32 points after operation. Fourteen hips were rated excellent and 12 hips rated good. There were four failures--one hip was revised for symptomatic loosening and three prosthesis were removed for infection. Twenty-seven of the hip replacements were subjectively rated as satisfactory by the patient. There was no significant difference in post-operative hip scores between cemented and uncemented prostheses. Total hip replacement in renal transplant recipients in this study has shown good long term result with a revision rate of about 3%. Late infection was a major problem with an incidence of 13%. Prophylactic antibiotics must be used whenever there is a risk of haematogenous seeding from transient bacteremia in these immunosuppressed patients. Use of uncemented prosthesis may make future revision arthroplasty easier.
Ann Acad Med Singap 1992 Sep
PMID:Results of total hip replacement in renal transplant recipients. 129 4

The incidence of scoliosis in cerebral palsy is related to the severity of the neurological involvement, being most prevalent in patients with spastic quadriplegia. Neuromuscular spinal deformity, when present, may progress after cessation of skeletal growth, and the success of orthotic treatment for scoliosis is unpredictable. Hip pathology is directly related to pelvic obliquity but has no causal relationship to the development of scoliosis. Adequate preoperative nutritional assessment is vital to reduce perioperative complications, and segmental spinal fixation is the instrumentation of choice. Anterior arthrodesis is indicated for rigid deformities and for those thoracolumbar and lumbar curves extending into the pelvis with pelvic obliquity and spinal decompensation.
Orthopade 1992 Sep
PMID:[Spinal disorders in cerebral palsy--surgical procedure]. 140 24

Classification of cerebral palsy according to the topographical distribution of clinical phenomena permits determination of a prognosis of the natural history of CP and the probability of hip problems to some extent. In 55 patients with CP, 101 muscle release operations were performed between 1971 and 1988. Preoperatively, the diagnosis was established by the neuropediatrician, function was evaluated according to the Rancho-los-amigos system, and the X-rays of the hip were assessed according to Reimers. For the postoperative evaluation patients were grouped according to neurologic diagnosis: hemiplegia (4), diplegia (19), total body involvement (31). Patients with hemiplegia had no functional or radiological changes as a result of the operation. In diplegia functional deterioration was seen in 4 cases (21%); in 3 cases (16%) this meant loss of the ability to walk. The migration percentage was improved from 48% to 39% on average. In 19 cerebral palsy patients with total body involvement surgery was considered to be indicated on the basis of a suspected dislocation of the hip. No functional changes occurred as a result of surgery. Hip dislocation was successfully prevented in 90% of the cases. The migration percentage was improved from 73% to 33%. In another 12 patients with total body involvement, adductor and iliopsoas release was performed to allow better hygiene and care and for pain relief. These goals were achieved; neither the Rancho-Los-Amigos function classification system nor X-rays were used to evaluate the results.
Orthopade 1992 Sep
PMID:[The hip in infantile cerebral palsy, natural developmental course and treatment concepts]. 140 25

High-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis, the Hip phenotype, results from mutations at the hip locus of Escherichia coli K-12. The nucleotide sequence of DNA fragments which complement these mutations revealed an operon consisting of a possible regulatory region, including sequences with modest homology to an E. coli promoter, and two open reading frames which are translated both in vitro and in vivo. The stop codon of a 264-bp open reading frame, hipB, and the start codon of a 1,320-bp open reading frame, hipA, share an adenine residue. Assays of promoter strength, the location of the probable promoter with respect to the start of transcription, and codon usage all indicate that hipB and hipA are weakly expressed genes. The activity of the promoter is impaired by an adjacent downstream sequence which includes the coding region of hipB. The impairment is partially relieved by insertion of a premature translation termination signal within the coding region of hipB, suggesting involvement of the HipB protein in the regulation of this promoter. The arrangement of hipB and hipA within the operon and the toxicity of hipA for strains defective in or lacking hipB suggest an important interaction between the products of these genes.
J Bacteriol 1991 Sep
PMID:Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. 171 62

Hip disarticulation, especially in patients with peripheral vascular disease, has been associated with high morbidity and mortality rates. This report describes patient characteristics that influence the clinical outcome of hip disarticulation. The medical records of all patients undergoing hip disarticulation from 1966 to 1989 were reviewed for surgical indication, perioperative wound complications, and postoperative deaths. Fifty-three patients underwent hip disarticulation for limb ischemia (10), infection (12), infection and ischemia (14), or tumor (17). The overall incidence of wound complications was 60%, and no significant differences were found among the groups. Prior above-knee amputation and urgent/emergent operations were significantly associated with increased wound complications (p less than 0.05). The overall mortality rate was 21%, ranging from 0% (tumor) to 50% (ischemia) and differed significantly among the groups (p less than 0.02). Mortality was significantly associated with urgent/emergent operations (p less than 0.01). Age, diabetes mellitus, and previous inflow procedures did not influence mortality rates. The presence of limb ischemia influenced mortality rates to a greater extent than did infection, and a history of cardiac disease was statistically predictive of death. Wound complications frequently accompanied hip disarticulation, regardless of operative indication, and were significantly increased by urgent/emergent operations and prior above-knee amputation. Hip disarticulation can be performed with low mortality rates in selected patients. Both limb ischemia and infection substantially increase operative mortality rates.
J Vasc Surg 1991 Sep
PMID:Hip disarticulation: factors affecting outcome. 188 Aug 49

Hip sonography enables an accurate and clinically relevant evaluation of hip maturation during the first days of human life. Experience has shown that an integration of hip sonography into neonatal screening programs is useful and necessary because clinical and even roentgenographic examination does not always establish a confirmed diagnosis of dysplasia.
Clin Orthop Relat Res 1990 Sep
PMID:Ultrasound examination for the early determination of dysplasia and congenital dislocation of neonatal hips. 220 68

On the basis of a study of the literature and observations in 53 of our own patients, we attempted to establish the cause and best treatment for neuropathic oblique pelvis. In addition, we tried to find out if certain kinds of neurologic dysfunctions coincide with certain kinds of oblique pelvis. It is highly probable that this pelvis malformation is the result of neuropathic spinal deformity. Severe oblique pelvis and scoliosis can be related to the severity of the neurologic dysfunction. Hip dislocation is not the reason for oblique pelvis. It can be assumed that hip dislocation, on the one hand, and oblique pelvis and scoliosis on the other can influence each other. To correct oblique pelvis, the neuropathic spinal deformity must be corrected. Anterior and posterior fusion, including the lumbosacral junction, give the best results.
Orthopade 1990 Sep
PMID:[Pelvic tilt in neuromuscular diseases]. 223 61

The authors compared seven radiologic indices of hip osteoarthritis to establish which provided the best definition of the disease for epidemiologic purposes. Hip joints were assessed from intravenous urograms taken in a British hospital between 1982 and 1987 in 1,315 men aged 60-75 years. The indices examined were an overall qualitative grading of osteoarthritis, four measures of joint space, the maximum thickness of subchondral sclerosis, and the size of the largest osteophyte. Minimal joint space (i.e., the shortest distance between the femoral head margin and the acetabulum) was the index most strongly associated with other radiologic features of osteoarthritis. Among a subset of 759 men who answered a questionnaire about symptoms, the overall qualitative grading, minimal joint space, and thickness of subchondral sclerosis were the radiologic indices most predictive of hip pain. Within- and between-observer repeatability were tested in a subset of 50 subjects. Measures of joint space were more reproducible than other indices. These data suggest that, at least in men, minimal joint space is the best radiologic criterion of hip osteoarthritis for use in epidemiologic studies.
Am J Epidemiol 1990 Sep
PMID:Defining osteoarthritis of the hip for epidemiologic studies. 238 55

The purpose of this study was to determine and compare the balance, muscular strength, and flexibility of two groups of elderly adults: one with a history of falls (HF) and one with no history of falls (NHF). Subjects were 19 men and 36 women. Static and dynamic balance was determined by a one-foot stance balance test and a backwards walking test. Hip, knee, and ankle joint muscular strength were assessed on a Cybex Leg Press Dynamometer. A goniometer was used to determine hip, knee, and ankle joint range of motion (flexibility), ANOVA indicated a significant difference between the two groups for static balance (p less than .001), leg strength (p less than .01), and hip and ankle flexibility (p less than .01). The results suggest that balance, leg strength, and flexibility may be factors contributing to falls in the elderly.
Arch Phys Med Rehabil 1990 Sep
PMID:Falls in the elderly: Part II, Balance, strength, and flexibility. 240 79


1 2 3 4 5 6 7 8 9 10 Next >>