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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Incidence rates of hip fracture are lower in Hispanic (HC) than non-Hispanic Caucasians (NHC). To investigate factors that may affect skeletal health of Hispanics, we recruited 152 healthy community-dwelling Mexican-American Caucasian women into a 4-year longitudinal study that evaluates bone mass, nutritional status, muscle strength, mobility, falls, and other factors that may contribute to fracture risk. Results from the baseline component of the study are reported herein. Average bone mineral densities (BMD) evaluated by dual-energy X-ray absorptiometry (DXA) in this study group did not differ from BMDs in healthy, NHC women of similar age. Hip axis length (HAL), however, was significantly shorter than that reported for nonosteoporotic NHC. Factors independently associated with greater BMD and BMC at certain skeletal sites were lean body mass, fat mass, acculturation, years of estrogen use, sun exposure, hip adductor strength, grip strength, erythrocyte folate, and serum glucose concentrations. Factors independently associated with lower BMD and BMC at certain skeletal sites were age, parity, and vertebral deformities (all p < 0.05). Thus, the decreased risk of hip fracture in HC compared with NHC does not appear to be due to high bone mass. However, other factors such as HAL and body composition may play a role in maintenance of skeletal integrity.
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PMID:Factors contributing to skeletal health of postmenopausal Mexican-American women. 858 28

Vertebral fractures are the most common osteoporotic fracture. Hip and clinical fractures are less common in black women, but there is little information on vertebral fractures. We studied 7860 white and 472 black women >or=65 yr of age enrolled in the Study of Osteoporotic Fractures. Prevalent vertebral fractures were identified from lateral spine radiographs using vertebral morphometry and defined if any vertebral height ratio was >3 SD below race-specific means for each vertebral level. Information on risk factors was obtained by questionnaire or examination. Lumbar spine, total hip, and femoral neck BMD and BMC were measured by DXA. The prevalence of vertebral fractures was 10.6% in black and 19.1% in white women. In age-adjusted logistic regression models, a 1 SD decrease in femoral neck BMD was associated with 47% increased odds of fracture in black women (OR = 1.47; 95% CI, 1.12-1.94) and 80% increased odds in white women (OR = 1.80; 95% CI, 1.68-1.94; interaction p = 0.14). The overall lower odds of fracture among black women compared with white women was independent of femoral neck BMD and other risk factors (OR = 0.51; 95% CI, 0.37-0.72). However, the prevalence of vertebral fractures increased with increasing number of risk factors in both groups. The prevalence of vertebral fractures is lower in black compared with white women but increases with age, low BMD, and number of risk factors.
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PMID:Prevalent vertebral fractures in black women and white women. 1844 9

We previously reported greater than average aBMD in adult Hutterites; however, it is unknown whether higher aBMD occurs at younger ages. We examined Hutterite children to test the hypotheses that aBMD Z-scores in younger (<15 years) Hutterite children would be similar to reference data; but greater in older children after they enter the adult workforce at age 15. A secondary aim was to determine lifestyle factors associated with bone measures among Hutterite children. Hip, femoral neck, and spine BMC and aBMD were measured in 323 Hutterite children aged 8 through 19 years: 186 (108 girls) were <15 years (younger) and 137 (87 girls) were >or=15 years (older). Anthropometric measurements and activity and dietary recalls were obtained. Overall, children were lighter (Z=-0.29+/-0.72 [mean+/-SD]), shorter (Z=-0.15+/-0.86, and had lower BMI's (Z=-0.27+/-0.70) than other South Dakota children residing in the same counties (all, p<or=0.002). Older girls and boys had higher percent time in moderate+vigorous activity (21+/-10% and 29+/-11% [mean+/-SD]) than younger girls and boys (15+/-10% and 18+/-10%, both p<0.001). Younger girls and boys had high hip aBMD Z-scores (0.30+/-1.0, 0.44+/-0.97; both greater than 0 at p<or=0.002). Younger males had low spine Z-score (-0.27+/-1.15, p=0.04). None of the Z-scores for the older ages were different from 0. Controlling for covariates, miles walked/day and grip strength were associated with greater hip bone area among girls (both, p<0.05). Grip strength was associated with hip and femoral neck BMC and hip aBMD among boys (all, p<0.05). Femoral neck bone area was inversely associated with calcium intake among boys (p<or=0.05), while higher hip BMC and spine BMC and aBMD were associated with increased vitamin D intake (all, p<or=0.05). Lean mass was an independent predictor of all bone measures, while fat mass was inversely associated with most measures of bone area. In summary, contrary to our hypothesis younger Hutterite children had greater hip aBMD Z scores than the normative DXA database, whereas older children did not. We speculate that high activity levels during the rapid growth phase leads to increased bone turnover and bone size; following bone consolidation later in young adulthood this will result in greater bone size and aBMD.
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PMID:High bone density in young Hutterite children. 1909 89

The relationship between aBMD and osteoarthritis (OA) remains unclear. We compared aBMD, BMC and bone size among children and grandchildren of Hutterites with hip or knee replacement (n=23 each) to children and grandchildren of age- and sex-matched controls (178 children and 267 grandchildren). There were no differences in anthropometric measures or activity levels between case and control probands, but femoral neck (FN) and spine (LS) aBMD and Z-scores were greater in cases than controls (0.89 vs. 0.80 g/cm2; 1.15 vs. 1.03 g/cm2; 1.5 vs. 0.8; 2.4 vs. 1.2: all p<0.05). Hip, FN and LS aBMD (1.05 vs. 0.97, 0.92 vs. 0.84, 1.15 vs. 1.03 g/cm2), BMC (34.1 vs. 32.0, 4.58 vs. 4.27, 69.5 vs. 62.4 g) and Z-scores (1.0 vs. 0.4; 0.9 vs. 0.2; 1.3 vs. 0.2) were greater in daughters of cases than controls (hip BMC p=0.06, others p<0.05); there were no differences between sons. Grandchildren (aged 8-39 years) were categorized as growing (premenarcheal or male<14 years) or not growing (> or =2 years post-menarcheal or males> or =18 years): 33 were not classified. Post-menarcheal, but not premenarcheal, granddaughters of cases had greater hip, FN and LS aBMD Z-scores (0.7 vs. -0.1; 0.6 vs. -0.1; 0.8 vs. -0.3); greater hip and spine aBMD (1.03 vs. 0.95, 1.10 vs. 0.98 g/cm2); greater femoral neck and spine BMC (4.77 vs. 4.21, 66.7 vs. 55.4 g); and greater spine bone area (60.7 vs. 56.6 cm2) compared to granddaughters of controls (all, p<0.05), which remained significant when height, weight, and age were included as covariates. Growing grandsons of cases were taller and heavier than control grandsons, and a greater hip aBMD among grandsons of cases (0.88 vs. 0.76 g/cm2) was the only bone difference that remained significant after taking into account body size differences. Grandsons who were not growing had greater spine bone area (1.19 vs. 1.08 cm2) if their grandparent had OA compared to grandsons whose grandparents did not have OA. We speculate that there is a genetic basis for OA that leads to early differences in growth patterns among boys and greater peak bone mass and aBMD among girls.
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PMID:Higher BMC and areal BMD in children and grandchildren of individuals with hip or knee replacement. 2005 77

Responsiveness to change is an important psychometric property of an outcome instrument. Assessment of health-related quality of life (HRQoL) is critical to outcome assessment after total joint replacement, a surgery aimed at improving pain, function and HRQoL of the patients undergoing these procedures. In a recent study, Shi et al. examined the responsiveness to change of various subscales of two instruments, physician-administered Harris Hip Score and patient self-administered Short Form-36 (SF-36), 6 months after revision total hip arthroplasty. The responsiveness statistics for both scales were reasonable, higher for Harris Hip Score than SF-36. This is the first study to examine responsiveness of these instruments in revision THA patients in a systematic fashion.
BMC Musculoskelet Disord 2011 May 23
PMID:Responsiveness differences in outcome instruments after revision hip arthroplasty: what are the implications? 2107 Jun 75