Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P50502 (
Hip
)
7,003
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In a retrospective study, we examined twenty-eight patients who had had an arthrodesis seventeen to fifty years previously (average, thirty-five years).
Hip
and knee ratings were obtained, as well as anteroposterior and flexion-extension radiographs of the lumbar spine and standing anteroposterior radiographs of the knees and hips. About 60 per cent of the patients had
pain
in the ipsilateral knee (average time to onset, twenty-three years after arthrodesis), and a similar percentage had back pain (average time to onset, twenty-five years after the operation).
Pain
in the contralateral hip occurred in approximately 25 per cent of the patients (average time to onset, twenty years after arthrodesis). Only one patient was unemployed due to disabling
pain
in the back or knee. Seventy per cent of the patients could walk more than one mile (1.6 kilometers), and a similar percentage could sit comfortably for at least two hours. Seventy-five per cent of the patients had anteroposterior laxity of the ipsilateral knee, and 80 per cent had mediolateral laxity. The patients whose hip was fused in some abduction more frequently had
pain
in the ipsilateral knee and the back, and they had greater degenerative changes in the ipsilateral knee than the patients whose hip was fused in adduction or in the neutral position. Six patients had undergone total hip arthroplasty for
pain
in the back or the ipsilateral knee, or both, and all had marked relief of back pain, while two of four had relief of
pain
in the knee. Two patients had a total knee arthroplasty for relief of
pain
in the ipsilateral knee.
...
PMID:Hip arthrodesis. A long-term follow-up. 407 3
The problem of treatment of a combination of failed hip arthroplasty secondary to resorption, osteoporosis, osteolysis, or fracture is unsolved. Twenty-seven such complicated hips, including four with previous infection, were treated by a femoral prosthesis driven into an intramedullary nail. The goal of stability, allowing immediate mobilization, was attained in virtually all patients. The oldest was 84 years of age and the mean age was 69.3 years. In the early postoperative period, one patient died of pulmonary embolism and one of myocardial infarction. Two infections were treated 25 and 11 months after implantation; these patients were free from
pain
and showed no signs of loosening of the implant. The mean time in the hospital for the infected patients was 60 days and for the noninfected patients was 23 days. Among 14 patients who were observed for at least ten months after surgery, freedom from
pain
was achieved in eight, significant alleviation of
pain
in five, and slight improvement in one. Five patients also became completely free from dependence on walking aids; seven used one or two canes. Two patients were dependent on crutches. Discrepancy in the length of the lower limbs was noted in seven patients. Six patients showed 1 cm shortening and one patient 2 cm. In six patients the Trendelenburg sign was negative, and in only three patients was it clearly positive. The mean Harris
Hip
Score in 14 patients observed for more than ten months after surgery was 82. Intramedullary nailing combined with a femoral component in total hip arthroplasties, where defects or fractures of the femur have occurred, give good fixation of the implant components and a satisfactory functional result.
...
PMID:Hip arthroplasty with an extended femoral stem for salvage procedures. 649 25
For the young adult patient with a painful hip in whom there is acetabular dysplasia, innominate osteotomy is not only an alternative to total hip replacement, but rather it is the procedure of choice. If the prerequisites for a Steel or a Chiari osteotomy are met and if the procedures are adequately carried out, satisfactory relief of
pain
and return to function can be expected. The length of the satisfactory result is unknown as yet because an insufficient number of patients have been followed over a long enough period to determine the life expectancy of these procedures. It would appear, however, that it is going to be more than 10 years, which is certainly longer than one could expect for the current generation of cemented total joint replacements to last. Cementless total joint replacements are so new that a comparison cannot be made, but intuitively, a procedure that can leave the patient with his own tissue is the procedure of choice. Certainly, in a well-executed Steel or Chiari osteotomy, later reconstruction or total joint replacement will not be compromised.
Hip
1984
PMID:Pelvic osteotomy: an alternative to total hip replacement in the young adult. 652 74
This has been a preliminary report with a short-term follow-up of a small number of observations (28 hips of 24 patients). The follow-ups ranged from 6 to 36 months, with an average of 17.8 months. Only eleven hips (in eleven patients) were followed an average of 8 months after cessation of the treatment. It should be emphasized that this was a "pilot" study, in which no control series was used to determine the natural course of the disease in a comparable clinical setting. Of note was the
pain
relief, in 19 of 23 patients with moderate to severe pretreatment
pain
. Also there was an improved function, which suggests that at least in approximately two thirds of the patients there was some clinical benefit from this mode of treatment. In eight hips, clinical conditions did not change; and in two they worsened, requiring further treatment. Eighteen remaining hips were thought to have been benefited by the treatment. Six femoral heads that had already developed varying degrees of collapse (Ficat Type III) collapsed further (1 to 2 mm), and two round heads (Ficat II) progressed to off-round (Ficat III). This preliminary study suggests that further exploration of pulsed electromagnetic fields (PEMFs) is warranted in the treatment of osteonecrosis of the femoral head.
Hip
1983
PMID:Osteonecrosis of the femoral head treated by pulsed electromagnetic fields (PEMFs): a preliminary report. 667 18
A 53-year-old man had the monomelic form of Ollier's disease, which resulted in deformity of the left leg. The patient was otherwise well until
pain
and increasing size of the left thigh led him to seek treatment. Biopsy revealed chondrosarcomatous transformation in the distal left femur.
Hip
disarticulation was performed. This case is unusual in that multiple foci of chondrosarcomatous transformation at various stages of development were present throughout the left femur, tibia, and fibula.
...
PMID:Ollier's disease with multiple sarcomatous transformations. 669 16
The benefits of multiple joint replacements were assessed in 21 patients with rheumatoid arthritis who had bilateral hip and knee replacements. The main benefit was relief of
pain
with 40 hips and 25 knees becoming completely
pain
-free. There was an improved range of movement in 38 hips but in only 11 knees and 8 knees were stiffer after surgery.
Hip
replacement was the preferred initial surgery but there was a mean delay of 50 months between hip and knee surgery suggesting a "domino effect" with increasing mobility as a consequence of hip replacement eventually causing knees to deteriorate. All patients who completed a postal questionnaire found their ability to walk had improved but many noted an increase in ankle and foot
pain
which limited their walking. After their surgery patients were better able to perform certain activities of daily life, especially housework and dressing. It is concluded that multiple joint replacement contributes to improving the quality of life in disabled arthritic patients.
...
PMID:Benefits of multiple joint replacement in rheumatoid arthritis. 671 95
Results of revision of 24 resurfacing hip prostheses followed up for a minimum of one year are encouraging. The average Iowa
Hip
Rating after salvage was higher than the average highest rating prior to failure of the original resurfacing procedure. There were no intraoperative complications in revising any of the failed resurfacing procedures. Results of revision of the failed component of a resurfacing procedure are comparable with those of conversion to a conventional hip arthroplasty. Thorough, prompt evaluation of hip pain in recipients of a hip resurfacing procedure is necessary for preservation of remaining bone stock. In comparison to revision of conventional hip arthroplasty, revision of failed resurfacing hip arthroplasty is technically easier and has a better prognosis in providing the patient with a
pain
-free, functional hip.
...
PMID:Analysis of revision surgery of resurfacing hip arthroplasty. 712 64
Although surface replacement hip arthroplasty has been viewed by some as a conservative alternative to conventional total hip arthroplasty, the surgical technique requires substantially more acetabular bone loss. To evaluate the efficacy of this operation, a retrospective study of 74 consecutive cases of surface replacement hip arthroplasty done at the University of California, San Francisco between February 1977 and June 1980 is reported and concludes that (1) there was no noteworthy difference in end result between cases using the Indiana, THARIES, or Freeman prostheses; (2) although there were major improvements in
pain
, function, and range of motion, unexplained
pain
persisted in 51.6% of cases; (3) the failure rate of 33.8% in the first 3 years was higher than that reported for conventional total hip arthroplasty; and (4) hips with a history of trauma failed the most frequently and showed the least improvement, whereas hips with osteoarthritis showed the fewest failures and the best results. We conclude that surface replacement hip arthroplasty is not superior to conventional total hip arthroplasty, judged by the criteria of
pain
relief, improvement of function, and failure rate.
Hip
1982
PMID:Surface replacement hip arthroplasty: results of the first seventy-four consecutive cases at the University of California, San Francisco. 716 97
Out of a total of 1031 patients with homozygous sickle cell (SS) disease attending a sickle cell clinic in Jamaica, 52 patients were found to have changes of avascular necrosis of the femoral head in 76 hips.
Hip
involvement was unilateral in 28 patients (31 males and 21 females). The age of onset varied from nine to 45 years in the 40 patients in whom data appeared reasonably reliable and 82% developed this lesion between 10 and 29 years. Radiological change occurred, by definition, in the femoral head in all hips, in the acetabulum in 55 (72%) hips, femoral head migration occurred in 37 (49%) hips, and periosteal new bone formation in 24 (32%) hips. Two broad patterns of involvement were discernible according to the age at which avascular necrosis had occurred. Involvement of the immature femoral head epiphysis resulted in a flattened femoral head, epiphysio-metaphyseal overlap, a wide femoral neck and a mushroom deformity of the mature femoral head. In these lesions the articular surface and joint space was generally well preserved and little or no disability resulted in adult patients. Involvement of the mature femoral head was typical segmental, most commonly antero-superior, and with continued weight bearing resulted in collapse of the head and disruption of the articular surface. These lesions caused
pain
, limitation of movement, and commonly changes of osteo-arthrosis.
...
PMID:The radiological features of avascular necrosis of the femoral head in homozygous sickle cell disease. 721 38
Myotatic reflexes can be enhanced following brief static contractions. Since static contractions are often used as precursors to muscle stretch, rationale underlying these techniques were questioned and re-examined through electromyography (EMG). Twenty-one female gymnasts performed three methods to produce hamstring stretch: static (S), contract-relax (CR), and contract-relax with agonist (hip flexors) contraction (CRAC).
Hip
joint angles and intra-individual electromyograms were statistically compared across stretch conditions. In 12 subjects, the CRAC method elicited significantly greater hamstring EMG activity (P < 0.05) than the other techniques. A higher level of muscle activation was associated with the S method in only one subject. No significant differences in EMG activity across stretch conditions were found in eight subjects suggesting that the relative effectiveness of the stretch techniques varied across individuals. Involuntary paroxysmal tremor activity was occasionally visible in EMG records of most subjects at the low levels of muscle activation. While apparently contributing to increased muscle stiffness, the CRAC technique produced the largest gains in hip flextion. Rank orderings of minimum
pain
and maximum perceived stretch effectiveness were significantly related with one another, and with decreasing EMG activity, but not with range of motion.
...
PMID:Electromyographic investigation of muscle stretching techniques. 745 8
<< Previous
1
2
3
4
5
6
7
8
9
10
Next >>