Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

40 patients with primary arthrosis were randomized to receive either a cemented SHP (Scientific Hip Prosthesis) or Lubinus SP2 prosthesis. At 2 years radiostereometric measurements showed increased proximal migration (0.4/0.2 mm; p = 0.02) and more proximal wear (0.3/0.1 mm, p = 0.01) of the SHP socket. The SHP stem also subsided (-O.6/-0.1 mm, p<0.001) and rotated more into retroversion (2.6/0.3 degrees ) than did the SP2 design. This subsidence mainly occurred inside the cement mantle in 17 of 18 cases (13 SHP, 4 SP2), where this type of motion could be measured. The changes in bone mineral density evaluated with DEXA and the clinical results did not differ between the 2 groups. The subsidence of the SHP stem is the most pronounced so far recorded with radiostereometry in stems without a completely polished surface. This subsidence and the rotational instability imply a substantial risk of abrasive wear and increased stresses in the cement mantle.
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PMID:Increased migration of the SHP prosthesis: radiostereometric comparison with the Lubinus SP2 design in 40 cases. 1066 21

Background and purpose - Recent studies have demonstrated a high incidence of postoperative periprosthetic femoral fracture (PPF) in elderly patients treated with 2 commonly used cemented, polished tapered stems. We compared the prevalence and incidence rate of PPF in a consecutive cohort of octagenerians with femoral neck fractures (FNFs) treated with either a collarless, polished tapered (CPT) stem or an anatomic matte stem (Lubinus SP2). Patients and methods - In a multicenter, prospective cohort study, we included 979 hips in patients aged 80 years and above (72% females, median age 86 (80-102) years) with a femoral neck fracture as indication for surgery. 69% of the patients were classified as ASA class 3 or 4. Hip-related complications and repeat surgery were assessed at a median follow-up of 20 (0-24) months postoperatively. Results - 22 hips (2.2%) sustained a PPF at a median of 7 (0-22) months postoperatively; 14 (64%) were Vancouver B2 fractures. 7 of the 22 surgically treated fractures required revision surgery, mainly due to deep infection. The cumulative incidence of PPFs was 3.8% in the CPT group, as compared with 0.2% in the SP2 group (p < 0.001). The risk ratio (RR) was 16 (95% CI: 2-120) using the SP2 group as denominator. Interpretation - The CPT stem was associated with a higher risk of PPF than the SP2 stem. We suggest that the tapered CPT stem should not be used for the treatment of femoral neck fractures in patients over 80 years.
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PMID:Substantially higher prevalence of postoperative peri-prosthetic fractures in octogenarians with hip fractures operated with a cemented, polished tapered stem rather than an anatomic stem. 2624 36