Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hip arthroplasty failure secondary to septic or aseptic loosening is common, but periprosthetic loosening caused by metastasis of a distant primary lesion is unusual and seldom described in the literature. In this report, we present the case of a 78-year-old woman with bipolar hemiarthroplasty implant loosening secondary to metastatic spread of papillary ovarian carcinoma. We also review the literature and describe the factors that could possibly predispose to metastatic seeding in patients with hip arthroplasty. In addition, we highlight the radiologic features that might help differentiate such loosening from other, more common causes at an early stage of presentation.
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PMID:Hip hemiarthroplasty periprosthetic loosening caused by papillary ovarian carcinoma metastasis in a 78-year-old woman: a rare presentation and a literature review. 2238 93

Tumor cells preferentially adopt aerobic glycolysis for their energy supply, a phenomenon known as the Warburg effect. It remains a matter of debate as to how the Warburg effect is regulated during tumor progression. Here, we show that CHIP (carboxyl terminus of Hsc70-interacting protein), a U-box E3 ligase, suppresses tumor progression in ovarian carcinomas by inhibiting aerobic glycolysis. While CHIP is downregulated in ovarian carcinoma, induced expression of CHIP results in significant inhibition of the tumor growth examined by in vitro and in vivo experiments. Reciprocally, depletion of CHIP leads to promotion of tumor growth. By a SiLAD proteomics analysis, we identified pyruvate kinase isoenzyme M2 (PKM2), a critical regulator of glycolysis in tumors, as a target that CHIP mediated for degradation. Accordingly, we show that CHIP regulates PKM2 protein stability and thereafter the energy metabolic processes. Depletion or knockout of CHIP increased the glycolytic products in both tumor and mouse embryonic fibroblast cells. Simultaneously, we observed that CHIP expression inversely correlated with PKM2 levels in human ovarian carcinomas. This study reveals a mechanism that the Warburg effect is regulated by CHIP through its function as an E3 ligase, which mediates the degradation of PKM2 during tumor progression. Our findings shed new light into understanding of ovarian carcinomas and may provide a new therapeutic strategy for ovarian cancer.
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PMID:CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma. 2834 25