Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P50502 (
Hip
)
7,003
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
C-terminal binding protein 2
(
CtBP2
) is a transcriptional co-repressor involved in cell migration, apoptosis, and tumorization. Up-regulation of
CtBP2
is implicated in various human cancers including breast cancers. In our present study, we found that the C-terminus of
Hsc70-interacting protein
(CHIP) regulated the steady-state level of
CtBP2
. CHIP interacted with
CtBP2
via a tetratricopeptide domain in the nucleus and ubiquitinated
CtBP2
, marking it for proteasomal degradation. Depletion of CHIP resulted in stabilization of the
CtBP2
protein, which was not affected by ultraviolet irradiation. Finally, CHIP expression regulated the expression of
CtBP2
target genes. Taken together, our data demonstrate that CHIP regulates the steady-state level of
CtBP2
as an E3 ubiquitin ligase and determines the expression levels of
CtBP2
target genes. Regulating
CtBP2
levels with CHIP may be a useful therapeutic strategy in human cancers.
...
PMID:C-terminus of Hsc70-interacting protein regulates C-terminal binding protein 2 and the expression of its target genes. 2341 Jul 50
