Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Background. Proximal femur defects resulting from tumor resections can be repaired with various types of hip endoprostheses. Major surgical procedures involving muscle detachments and extensive endoprosthesis implantation are prone to deep infections and the hip instability. The purpose of our study was to assess the outcome of hip prosthesoplasty after resection of large tumors from the proximal femur. Material and methods. Over the last 5 years, 49 patients have undergone hip prosthesoplasty after tumor resection in the proximal femur for 37 bone metastases and 12 primary neoplasms during the last 5 years. Three total megaprostheses were used, as well as 34 conventional long stem endoprostheses, including 26 bipolar and 12 Austin Moore prostheses. Results. Two patients died shortly after surgery, and another 4 were nonambulatory due to diffusion of the cancer. There were 3 cases of endoprosthesis luxation, 1 deep implant infection and 1 metastasis recurrence. We had 28% excellent functional outcomes and 60% good; the latter were complicated by Trendelenburg gait. Conclusions. Hip instability is the most common complication in prosthesoplasty after tumor resection in the proximal femur.
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PMID:Results of the megaprosthesis replacement reconstruction proximal femoral resection bone tumors. 1761 20

Patients presenting with skeletal metastatic lesions requiring surgery are increasing, this is due to an ageing population and improved oncological survival following advances in medical management. Furthermore, patients are living longer with skeletal metastatic disease. The majority of bone metastases occur in the proximal femur. Robust diagnosis (Biopsy) and treatment is required to ensure that patients can mobilise fully weight bearing immediately post-surgery and that the construct should outlive the patients expected survival. We review the changing management of metastatic disease in the proximal femur.
Hip Int 2017 Feb 21
PMID:Current orthopaedic management of bony metastases in the proximal third of the femur. 2821 77

Limb salvage procedures are considered the gold standard in the treatment of bone tumours. The use of modular prostheses is one of the options for reconstruction after bone resection in primary tumours and in very restricted cases also in bone metastases. The authors report the results of 27 consecutive cases of proximal femur bone resections and reconstructions with modular prostheses, using the Mutars system. Soft tissue reconstruction and anchorage to the implant was performed using the Trevira tube. The system stem used showed good mechanical resistance, and implant removal was required for infection in only two cases. Functional results were related to the degree of bone resection and muscular sacrifice. (Hip International 2005; 15: 218-22).
Hip Int
PMID:Endoprosthetic replacement for malignant bone tumours of the proximal femur. 2822 91