Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Walkabout orthosis is a relatively new device for assisted standing and mobility in spinal paralysed individuals. The design, with a medially-mounted single-axis hinge joint linking two knee-ankle-foot orthoses, is quite different to other currently available orthoses which have laterally positioned hip joints such as the Reciprocal Gait Orthosis or Hip Guidance Orthosis. Twenty-five spinal cord injured patients were fitted and trained with the Walkabout orthosis and followed up regularly for just under 2 years on average. Sixty percent of all the patients fitted have incorporated use of the Walkabout orthosis into their lifestyles. Maintenance of joint mobility and psychological benefits were the most important outcomes of Walkabout usage. Loss of thoraco-lumbar mobility was found to be a limiting factor in successful use of the Walkabout orthosis in patients without active hip flexion. Patient selection criteria should include demonstrated spinal stability without significant deformity, controlled muscle spasm, less than 5 degrees of hip or knee flexion contracture, achievable neutral ankle position, mobility of the thoraco-lumbar spine into lateral flexion, good upper limb strength, and motivation with realistic expectations.
Spinal Cord 1997 Sep
PMID:Clinical evaluation of a new orthosis, the 'walkabout', for restoration of functional standing and short distance mobility in spinal paralysed individuals. 930 Sep 61

Heterotopic ossification (HO) is an important cause of restriction in range of movements and secondary motor disability following neurotrauma, orthopaedic interventions and burns. It has not received focussed attention in non-traumatic neurological disorders. In a prospective study of 377 patients, on medical problems in neurological rehabilitation setting, 15 subjects (3.97%) had neurogenic heterotopic ossification. Their clinical diagnosis was: transverse myelitis (7), neurotuberculosis (4), traumatic myelopathy (2) and stroke (2). Hip (10), knee (4) and elbow joints (1) were involved. The risk factors included urinary tract infection (15), spasticity (6), pressure sores (13) and deep venous thrombosis (DVT) (6). The initial diagnosis was often other than HO and included DVT (3), haematoma (2) and arthritis (2). ESR and serum alkaline phosphatase levels were elevated in all but one subject. The diagnosis of HO was established using X-rays, CT Scan and three-phase bone scan. Following treatment with non-steroidal anti-inflammatory drugs, the range of motion improved in only four patients. HO resulted in significant loss of therapy time during rehabilitation. High index of suspicion about this complication is necessary for early diagnosis and prompt intervention.
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PMID:Neurogenic heterotopic ossification : a diagnostic and therapeutic challenge in neurorehabilitation. 1130 39

In an effort to overcome the disadvantages of reciprocating gait orthoses (RGOs) and medial linkage orthoses (MLOs), a new design of MLO was developed. Therefore the aim of this study was comparison effect of a new reciprocating MLO and traditional isocentric RGO on gait parameters and functional independence (orthosis donning and doffing time) in spinal cord injury (SCI) subjects to provide more evidence of its efficacy. Four people with motor incomplete SCI participated in this study. Each participant was fitted with an MLO and isocentric reciprocating gait orthosis (IRGO) to enable a comparison of walking speed, cadence and endurance to be performed. There were no statistically significant differences demonstrated in temporal-spatial parameters between the orthotic walking conditions in this study, but walking with the MLO improved the stride length and speed of walking by 28.57 and 40.9% compared with walking with an IRGO as a control condition. Hip flexion occurred predominantly during single-support phases, with negligible motion during double-support phases. The first and second Subjects had hip kinematic pattern more near normal when they walked with medial linkage reciprocal gait orthosis (MLRGO) in comparison with IRGO. There was significant difference between donning and doffing in two conditions (P=0.046) but there was not significant difference between two conditions in standing and sitting although these two conditions improved by new MLO. The new MLO provided a quicker and more independent gait compared with IRGO, in addition the new MLO made it easier for subjects to get from sitting to standing and from standing to sitting.
Spinal Cord Ser Cases 2016
PMID:The influence of new medial linkage orthosis on walking and independence in spinal cord injury patients: a pilot study. 3126 10