Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Query: UNIPROT:P50502 (
Hip
)
7,003
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hip
involvement is uncommon in
familial Mediterranean fever
(
FMF
) and can result either from a process specific to this disease or from a coexisting chronic inflammatory joint disease, usually suggestive of ankylosing spondylitis (AS). We report ten cases of
FMF
with radiologically-documented inflammatory hip disease. Five patients had AS and one had juvenile idiopathic arthritis. There were six men and four women, with a mean age of 34.4 years +/- 17.6 (range, 15-70 years). Onset of the inflammatory hip disease occurred after bouts of acute hip symptoms in one of the patients with isolated
FMF
and after protracted hip arthritis in another; the two other patients had no history of hip symptoms. The HLA-B27 antigen was looked for in two of the five patients with
FMF
and AS, with negative results in both; another patient in this subgroup had severe ulcerative colitis. Total hip replacement or replacement of the acetabulum was required in six patients, including two with isolated
FMF
. Chronic joint disease has been estimated to contribute fewer than 5% of the joint manifestations in
FMF
. In previous studies, the hips and knees were affected in 75% of patients with chronic joint disease related to
FMF
. The association of
FMF
and AS (usually without the HLA-B27 antigen) has been well documented, although the pathogenic mechanisms that link these two conditions remain unknown.
...
PMID:Hip involvement in patients with familial Mediterranean fever. A review of ten cases. 1253 63
The most common arthritic involvement in
familial Mediterranean fever
(
FMF
) is acute self- limiting monoarthritis which typically lasts for 72 h.
Hip
joint involvement is uncommon in
FMF
and can result either from a process specific to this disease or from a coexisting inflammatory joint disease. We describe a 37-year-old woman with
FMF
and right osteoarthritis secondary to congenital hip dislocation.
Periodic fever
with right coxalgia lasting for 6 months was treated using colchicine. Genetic analysis revealed homozygous mutation in the MEFV gene (L110P-E148Q/L110P-E148Q), confirming the
FMF
diagnosis. Although the clinical presentation and course of
FMF
arthritis are diverse, delineating these clinical patterns may help with early recognition and treatment to prevent destructive arthritis in
FMF
. Clinicians should consider the possibility of
FMF
development in unusual monoarthritis patients with recurrent febrile attacks.
...
PMID:Protracted arthritis in a Japanese patient with familial Mediterranean fever. 2580 Jun 39
