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Query: UNIPROT:P50502 (Hip)
 7,003 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Total joint arthroplasty may be considered as a last option to treat osteopetrosis associated with osteoarthritis. However, many intraoperative and postoperative challenges need to be overcome when performing arthroplasty in patients with osteopetrosis, and few studies have focused on the longer-term outcomes.This article describes a case of a 22-year-old woman with osteopetrosis who presented with osteoarthritis and underwent right total hip arthroplasty 10 years prior. A smaller and shorter femoral component was chosen for the patient, special tungsten steel drill bits were used to create the femoral canal, and the drilling process was under fluoroscopic guidance. In the second postoperative week, her Harris Hip Score increased to 82.15 points from 40.25 points preoperatively. No postoperative complications were seen, and radiographs illustrated the components were in good position. At 10-year follow-up, her Harris Hip Score was still 82 points, the components were in good position radiographically, and the patient could walk freely and perform activities of daily living with no pain. The success of the treatment lies in suitable selection of prosthesis components, extra caution during surgery, adequate perioperative antibiotic administration, postoperative functional exercise, and a low-calcium diet.
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PMID:Total joint arthroplasty in a patient with osteopetrosis: 10-year follow-up. 2041 6

Proximal femoral fracture and coxarthrosis are the most common orthopaedic problems of osteopetrosis. Fracture fixation is difficult and one-third fail, with total hip replacement as the final solution. There is little reported experience about how to deal with this particular type of bone and what has been published to date is surprisingly non-specific. Corrective osteotomies are mainly undertaken in children for non-union of a fractured femoral neck and/or for coxa vara. However, any information about technical problems and solutions is scarce and barely instructive. Osteotomy experience for osteopetrosis in youngsters and young adults has not been reported. Osteopetrosis bone is characterized by a small tolerance for displacement and by the high friction experienced when penetrating instruments and implants are used. This article describes the risks of hip surgery in the presence of osteopetrosis and also discusses osteotomies around the hip and how to limit any related complications. Four patients, who underwent different types of hip preservation procedure, have been used to illustrate the difficulties that can be encountered. The article also suggests ways to make osteotomies feasible in osteopetrosis bone, even in adults.
J Hip Preserv Surg 2017 Dec
PMID:Technical particularities of joint preserving hip surgery in osteopetrosis. 2925 Mar 35

Osteopetrosis is a disorder of diminished bone resorption with hard and brittle bones resulting in high rates of perioperative complications during an operative intervention. We present a series of 4 Subtrochanteric fractures treated surgically in 3 patients of Osteopetrosis in a tertiary level Orthopaedic centre over the last 3 years with an aim to highlight our preparation and technique, especially as a guide to other surgeons, to minimize the complication rates and optimise the results. The patients had a mean Harris Hip Score of 85, at a mean follow up of 21.5 months ; the fractures united and all patients successfully returned to their normal activities of daily living.
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PMID:Fracture Management In Osteopetrosis : An Intriguing Enigma A Guide For Surgeons. 3042 53

Osteopetrosis (OP) is a group of rare sclerosing bone dysplasia characterized by increased bone density. The benign autosomal dominant form is the most common type. It typically carries a full life expectancy, despite increased propensity for fractures and other musculoskeletal problems, particularly hip osteoarthritis. In the current literature, the youngest OP patient having hip osteoarthritis is 16 years of age and treated with total hip arthroplasty. Within the present study, a 16-year-old female patient with early-onset hip osteoarthritis treated with hip joint debridement and femoral head reshaping is presented. The pain relieved and hip joint movements recovered to almost normal range. At the final follow-up at 2 years after the surgery, the patient was still free of pain and ambulating without restriction. Hip joint debridement and femoral shaping may be beneficial in hip osteoarthritis secondary to OP in adolescents, and may delay hip arthroplasty in a young age.
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PMID:Management of early-onset hip osteoarthritis in an adolescent patient with osteopetrosis tarda: a case report. 3058 79